Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy

Wang, Can; Wang, Zhiting; He, Meiling; Zhou, Tiantian; Niu, Yayan; Sun, Shengxuan; Li, Hui; Zhang, Ce; Zhang, Shengnan; Li, Meng; Xu, Ying; Dong, Ningzheng; Wu, Qingyu

doi:10.1073/pnas.2003913117

Cited by 26 publications

(21 citation statements)

References 55 publications

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“…Mouse blood pressure was measured using a computerized photoelectric tail-cuff apparatus (BP-2000, Visitech Systems, Apex, NC, USA), as previously described [ 86 ]. Briefly, the apparatus included a warmed platform with a cover to provide a calm environment.…”

Section: Methodsmentioning

confidence: 99%

Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis

Zhou

Zhang

et al. 2022

IJMS

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Atrial natriuretic peptide (ANP)-mediated natriuresis is known as a cardiac endocrine function in sodium and body fluid homeostasis. Corin is a protease essential for ANP activation. Here, we studied the role of renal corin in regulating salt excretion and blood pressure. We created corin conditional knockout (cKO), in which the Corin gene was selectively disrupted in the kidney (kcKO) or heart (hcKO). We examined the blood pressure, urinary Na+ and Cl− excretion, and cardiac hypertrophy in wild-type, corin global KO, kcKO, and hcKO mice fed normal- and high-salt diets. We found that on a normal-salt diet (0.3% NaCl), corin kcKO and hcKO mice had increased blood pressure, indicating that both renal and cardiac corin is necessary for normal blood pressure in mice. On a high-salt diet (4% NaCl), reduced urinary Na+ and Cl− excretion, increased body weight, salt-exacerbated hypertension, and cardiac hypertrophy were observed in corin kcKO mice. In contrast, impaired urinary Na+ and Cl− excretion and salt-exacerbated hypertension were not observed in corin hcKO mice. These results indicated that renal corin function is important in enhancing natriuresis upon high salt intakes and that this function cannot be compensated by the cardiac corin function in mice.

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Section: Methodsmentioning

confidence: 99%

Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis

Zhou

Zhang

et al. 2022

IJMS

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“…During early pregnancy, extravillous trophoblasts move upstream along the arterial wall and migrate to, invade, and replace vascular smooth muscle cells and endothelial cells, thereby remodeling the uterine spiral arteries ( 35 ). Several cytokines produced by the placenta, such as vascular endothelial growth factor-A ( VEGF-A ), insulin-like growth factor, Krüppel-like factor 17, atrial natriuretic peptide may play important roles in the formation of the maternal-fetal vasculature ( 35 , 36 ). Amin et al.…”

Section: Omics Studies Investigating the Establishment And Maintenanc...mentioning

confidence: 99%

Multiomics Studies Investigating Recurrent Pregnancy Loss: An Effective Tool for Mechanism Exploration

Wang

Ding

et al. 2022

Front. Immunol.

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Patients with recurrent pregnancy loss (RPL) account for approximately 1%-5% of women aiming to achieve childbirth. Although studies have shown that RPL is associated with failure of endometrial decidualization, placental dysfunction, and immune microenvironment disorder at the maternal-fetal interface, the exact pathogenesis remains unknown. With the development of high-throughput technology, more studies have focused on the genomics, transcriptomics, proteomics and metabolomics of RPL, and new gene mutations and new biomarkers of RPL have been discovered, providing an opportunity to explore the pathogenesis of RPL from different biological processes. Bioinformatics analyses of these differentially expressed genes, proteins and metabolites also reflect the biological pathways involved in RPL, laying a foundation for further research. In this review, we summarize the findings of omics studies investigating decidual tissue, villous tissue and blood from patients with RPL and identify some possible limitations of current studies.

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“…In mice, corin deficiency abolishes ANP activation (25,26). Both corin and ANP are expressed in the pregnant uterus (27)(28)(29)(30)(31). In mice, corin or ANP deficiency impairs trophoblast invasion and spiral artery remodeling, leading to a preeclampsialike phenotype (27,28,32).…”

Section: Introductionmentioning

confidence: 99%

“…Both corin and ANP are expressed in the pregnant uterus (27)(28)(29)(30)(31). In mice, corin or ANP deficiency impairs trophoblast invasion and spiral artery remodeling, leading to a preeclampsialike phenotype (27,28,32). CORIN variants impairing corin function have been identified in preeclamptic women (27,33,34).…”

Section: Introductionmentioning

confidence: 99%

Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling

Zhang¹,

Li²,

Lou³

et al. 2021

Journal of Clinical Investigation

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Atrial natriuretic peptide (ANP) is an important hormone in cardiovascular biology. It is activated by the protease corin. In pregnancy, ANP and corin promote uterine spiral artery remodeling, but the underlying mechanism remains unknown. Here we report an ANP function in uterine decidualization and TNF-related apoptosis-induced ligand (TRAIL)-dependent death in spiral arterial smooth muscle cells (SMCs) and endothelial cells (ECs). In ANP-or corin-deficient mice, uterine decidualization markers and TRAIL expression were decreased, whereas in cultured human endometrial stromal cells (HESCs), ANP increased decidualization and TRAIL expression.In uterine spiral arteries from pregnant wild-type mice, SMC and EC loss occurred sequentially before trophoblast invasion. In culture, TRAIL from decidualized HESCs induced apoptosis in uterine SMCs, but not in ECs with low TRAIL receptor expression. Subsequently, cyclophilin B was identified from apoptotic SMCs that up-regulated endothelial TRAIL receptor and caused apoptosis in ECs. These results indicate that ANP promotes decidualization and TRAIL expression in endometrial stromal cells, contributing to sequential events in remodeling spiral arteries, including SMC death and cyclophilin B release, which in turn induces TRAIL receptor expression and apoptosis in ECs.

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Krüppel-like factor 17 upregulates uterine corin expression and promotes spiral artery remodeling in pregnancy

Cited by 26 publications

References 55 publications

Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis

Renal Corin Is Essential for Normal Blood Pressure and Sodium Homeostasis

Multiomics Studies Investigating Recurrent Pregnancy Loss: An Effective Tool for Mechanism Exploration

Atrial natriuretic peptide promotes uterine decidualization and a TRAIL-dependent mechanism in spiral artery remodeling

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