KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice

Chuang, Sung-Ting; Kuo, Yueh‐Hsiung; Su, Ming‐Jai

doi:10.1016/j.ejphar.2015.01.020

Cited by 25 publications

(17 citation statements)

References 31 publications

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“…Consistent with previous studies, UUO led to rapid inflammation in the affected kidneys [17]. We found that anti-CD20 antibody decreased the UUO-induced up-regulation of tumour necrosis factor-α (Tnfa) and vascular cell adhesion molecule 1 (Vcam1) mRNA levels ( Figure 5F, G).…”

Section: B-cell Depletion Alters Chemotactic and Pro-inflammatory Ressupporting

confidence: 91%

Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction

Han

Zhu

Wang

et al. 2016

The Journal of Pathology

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Section: B-cell Depletion Alters Chemotactic and Pro-inflammatory Ressupporting

confidence: 91%

Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction

Han

Zhu

Wang

et al. 2016

The Journal of Pathology

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“…Mia and Bank [59] demonstrated an antifibrotic effect of CAPE in human dermal and lung fibroblasts, where an inhibition of fibroblast transformation into myofibroblasts and a suppression of collagen and fibronectin expression were shown. In other studies, the antifibrotic effects of CAPE led to reduced collagen and fibronectin deposition in mice and rats in vivo [28,60,61]. …”

Section: Discussionmentioning

confidence: 92%

Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents

et al. 2018

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To prevent implant failure due to fibrosis is a major objective in glaucoma research. The present study investigated the antifibrotic effects of paclitaxel (PTX), caffeic acid phenethyl ester (CAPE), and pirfenidone (PFD) coated microstent test specimens in a rat model. Test specimens based on a biodegradable blend of poly(4-hydroxybutyrate) biopolymer and atactic poly(3-hydroxybutyrate) (at.P(3HB)) were manufactured, equipped with local drug delivery (LDD) coatings, and implanted in the subcutaneous white fat depot. Postoperatively, test specimens were explanted and analyzed for residual drug content. Fat depots including the test specimens were histologically analyzed. In vitro drug release studies revealed an initial burst for LDD devices. In vivo, slow drug release of PTX was found, whereas it already completed 1 week postoperatively for CAPE and PFD LDD devices. Histological examinations revealed a massive cell infiltration in the periphery of the test specimens. Compact fibrotic capsules around the LDD devices were detectable at 4–36 weeks and least pronounced around PFD-coated specimens. Capsules stained positive for extracellular matrix (ECM) components. The presented model offers possibilities to investigate release kinetics and the antifibrotic potential of drugs in vivo as well as the identification of more effective agents for a novel generation of drug-eluting glaucoma microstents.

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“…The superoxide dismutase (SOD) family is the main antioxidant system and is of importance in oxidative stress modulation [ 32 ]. Increased oxidative stress in obstructive nephropathy is always accompanied by decreased SOD expression [ 5 , 33 ]. Our results demonstrated that the mRNA levels of SOD1-3 were significantly diminished in obstructed kidneys.…”

Section: Discussionmentioning

confidence: 99%

MnTBAP therapy attenuates the downregulation of sodium transporters in obstructive kidney disease

et al. 2017

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Ureteral obstruction is associated with reduced expressions of renal sodium transporters, which contributes to impaired urinary concentrating capacity. In this study, we employed a synthetic mitochondrial superoxide dismutase 2 (SOD2) mimic MnTBAP to investigate the role of mitochondrial oxidative stress in modulating the sodium transporters in obstructive kidney disease. Following unilateral ureteral obstruction (UUO) for 7 days, a global reduction of sodium transporters including NHE3, NCC, NKCC2, and ENaCα was observed as determined by qRT-PCR, Western Blotting or immunohistochemistry. Among these sodium transporters, the downregulation of NHE3, NCC, and NKCC2 was partially reversed by MnTBAP treatment. In contrast, the reduction of ENaCα was not affected by MnTBAP. The β and γ subunits of ENaC were not significantly altered by ureteral obstruction or MnTBAP therapy. To further confirm the anti-oxidant effect of MnTBAP, we examined the levels of TBARs in the urine collected from the obstructed ureters of UUO mice and bladder of sham mice. As expected, the increment of urinary TBARs in UUO mice was entirely abolished by MnTBAP therapy, indicating an amelioration of oxidative stress. Meantime, we found that three types of SOD were all reduced in obstructed kidneys determined by qRT-PCR, which was unaffected by MnTBAP. Collectively, these results demonstrated an important role of mitochondrial oxidative stress in mediating the downregulation of sodium transporters in obstructive kidney disease.

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KS370G, a caffeamide derivative, attenuates unilateral ureteral obstruction-induced renal fibrosis by the reduction of inflammation and oxidative stress in mice

Cited by 25 publications

References 31 publications

Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction

Renal recruitment of B lymphocytes exacerbates tubulointerstitial fibrosis by promoting monocyte mobilization and infiltration after unilateral ureteral obstruction

Development of a biodegradable antifibrotic local drug delivery system for glaucoma microstents

MnTBAP therapy attenuates the downregulation of sodium transporters in obstructive kidney disease

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