Kuersetin'in Sipermetrin Kaynaklı Mide Hasarı Üzerine Etkileri: Oksidatif Stres, Enflamasyon ve Apoptozun Rolü

Akaras, Nurhan; Gür, Cihan; Şimşek, Hasan; Tuncer, Sibel Çiğdem

doi:10.37989/gumussagbil.1225539

Gümüşhane Üniversitesi Sağlık Bilimleri Dergisi

2023

DOI: 10.37989/gumussagbil.1225539

|View full text |Cite

Kuersetin'in Sipermetrin Kaynaklı Mide Hasarı Üzerine Etkileri: Oksidatif Stres, Enflamasyon ve Apoptozun Rolü

Nurhan Akaras

Cihan Gür

Hasan Şimşek

et al.

Abstract: This study was conducted to investigate the effects of quercetin (QUE) on cypermethrin (CYP) induced gastrotoxicity in rats. 35 Sprague-Dawley rats were randomly divided into five groups, 7 in each group. In the study, 25 and 50 mg/kg QUE were administered orally 30 min after 25 mg/kg cypermethrin was administered to rats for 28 days. Oxidative stress, inflammation, ER stress, apoptosis and autophagy markers were biochemically analyzed in gastric tissues. Additionally, histological analysis was performed for m… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2023

2024

Publication Types

Select...

Article3

Relationship

Self Cite0

Independent3

Authors

Journals

Cited by 3 publications

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Investigation of the Effects of Acetylsalicylic Acid Administration at Different Doses on Behavioral Disorders in Rats

Şimşek,

Kandemir,

Akaras

2024

Türk Doğa Ve Fen Dergisi

View full text Add to dashboard Cite

Aspirin is one of the most widely used non-steroidal anti-inflammatory drugs worldwide. Neurodegenerative diseases adversely affect the central nervous system, leading to cognitive decline. Aspirin has different pharmacological activities at different doses. Therefore, this study aimed to determine the effects of acetylsalicylic acid (ASA), the active ingredient of aspirin, administered at different doses on the parameters that play a role in cognitive function using molecular and histological methods and behavioral tests. For this purpose, 28 Wistar rats were divided into 4 groups. Control, ASA-low dose (1mg/kg), ASA-moderate dose (10mg/kg) and ASA-high dose (100mg/kg). ASA was intragastrically administered as a single dose, and an open field test was performed 3 hours later. Subsequently, hippocampus tissues were obtained, and the hippocampus tissue structure was analyzed by analyzing the parameters involved in antioxidant capacity, inflammation, apoptosis, and memory. ASA, especially at moderate doses, increased antioxidant capacity and partially reduced inflammation and apoptotic damage. At high doses, the opposite effect was observed, and the damage levels. Similar effects were detected by histological examination. Although there were no structural defects at low or moderate doses, structural defects were observed at high doses. Although there was no difference in the open field test findings between the groups, the time spent in the center, distance traveled, and speed was slightly higher in the ASA moderate-dose group. In conclusion, ASA may contribute to the improvement of cognitive function at low and moderate doses. However, high doses may cause cognitive impairment.

show abstract

Investigation of the Effects of Acetylsalicylic Acid Administration at Different Doses on Behavioral Disorders in Rats

Şimşek,

Kandemir,

Akaras

2024

Türk Doğa Ve Fen Dergisi

View full text Add to dashboard Cite

show abstract

Carvacrol Ameliorates Cisplatin-Induced Cardiotoxicity By Regulating Notch/Hes1 Signaling Pathway, Oxidative Stress and Cell Death In Rat Cardiac Tissue

Akaras,

Kandemir,

Şimşek

2024

Türk Doğa Ve Fen Dergisi

View full text Add to dashboard Cite

Cisplatin is one of the most active cytotoxic agents used mainly in the treatment of solid tumors. High doses and long-term use of Cisplatin are known to cause cardiotoxicity. In recent years, the antiapoptotic and antioxidant effects of Carvacrol in cardiovascular diseases have attracted attention. In this study, the effects of Carvacrol on Cisplatin-induced cardiotoxicity in a rat model were investigated using biochemical and histological methods. Twenty-eight rats were divided into 4 groups: 1. Control group, 2. Carvacrol group, 3. Cisplatin group, 4. Cisplatin + Carvacrol group. The expression of antioxidant enzymes, proinflammatory cytokines, apoptotic, and autophagic proteins was examined in heart tissue obtained from rats sacrificed after the last drug administration. Additionally, heart tissue was evaluated histopathologically. Cisplatin has been observed to cause oxidative stress and inflammatory damage in animal heart tissue. Carvacrol administration significantly increased antioxidant enzyme (superoxide dismutase and glutathione peroxidase) activities while suppressing inflammatory markers (NF-κB, TNF-α, IL-1β). Additionally, Cisplatin induced apoptotic (caspase-3, Bax, Bcl-2) and autophagic (Beclin-1, LC3A, LC3B) markers. It has been determined that carvacrol can protect heart tissues from the destructive effects of cisplatin by exerting anti-apoptotic and anti-autophagic effects. The expression levels of Notch1 and Hes1, which were decreased by cisplatin administration, were upregulated after administration of Carvacrol. H&E staining results showed that Carvacrol preserved myocardial tissue integrity. In conclusion, Carvacrol showed a cardioprotective effect against cisplatin-induced cardiotoxicity.

show abstract

Naringin is Protective in Paclitaxel-Induced Peripheral Neuropathy; A Multi-Biomarker Approach

YILMAZ,

ŞİMŞEK,

KÜÇÜKLER

et al. 2023

New Trends in Medicine Sciences

View full text Add to dashboard Cite

Aim: Cancer is a disease that is on the rise worldwide. Paclitaxel (PTX) is one of the most common chemotherapeutic agents used in the treatment of many cancers. PTX causes toxic effects by increasing oxidative stress in tissues. Naringin is a powerful antioxidant found naturally in many plants, especially citrus fruits. The aim of this study was to determine the protective effects of NRG in PTX-induced sciatic nerve injury. Methods: Thirty-five male rats were randomly divided into five groups: control, PTX, NRG, PTX+NRG-50, PTX+NRG-100. PTX was administered i.p. for the first five days and NRG 50 or 100 mg/kg orally on days 6-14. Sciatic nerve tissues were harvested and analyzed for markers of oxidative stress, inflammation and apoptosis damage levels by biochemical methods. Results: PTX caused oxidative stress damage by increasing lipid peroxidation (MDA) and decreasing antioxidant capacity (SOD, CAT, GPx and GSH), inflammatory damage by increasing proinflammatory cytokine (NF-κB, TNF-α, IL-1β, SIRT1, TLR4, and NRF2) release, apoptotic damage by increasing apoptotic factor (Bax) and decreasing antiapoptotic factor (Bcl-2) in sciatic nerve tissue (p < 0.05). NRG, on the other hand, reversed all these changes in sciatic nerve tissue and reduced PTX-induced oxidative stress damage, inflammatory damage and apoptotic damage (p < 0.05). These effects were more effective at the 100 mg/kg dose of NRG than at the 50 mg/kg dose (p < 0.05). Conclusions: In sciatic nerve tissue, PTX induced peripheral neuropathy with increased oxidative stress, inflammation and apoptotic damage. NRG showed a protective effect against PTX-induced peripheral neuropathy.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Kuersetin'in Sipermetrin Kaynaklı Mide Hasarı Üzerine Etkileri: Oksidatif Stres, Enflamasyon ve Apoptozun Rolü

Cited by 3 publications

References 39 publications

Investigation of the Effects of Acetylsalicylic Acid Administration at Different Doses on Behavioral Disorders in Rats

Investigation of the Effects of Acetylsalicylic Acid Administration at Different Doses on Behavioral Disorders in Rats

Carvacrol Ameliorates Cisplatin-Induced Cardiotoxicity By Regulating Notch/Hes1 Signaling Pathway, Oxidative Stress and Cell Death In Rat Cardiac Tissue

Naringin is Protective in Paclitaxel-Induced Peripheral Neuropathy; A Multi-Biomarker Approach

Contact Info

Product

Resources

About