Kujigamberol, a new dinorlabdane diterpenoid isolated from 85million years old Kuji amber using a biotechnological assay

Kimura, Ken‐ichi; Minamikawa, Yuki; Ogasawara, Yukiko; Yoshida, Jun; Saitoh, Kei-ichi; Shinden, Hisao; Ye, Yue Qi; Takahashi, Shigetoshi; Miyakawa, Tokichi; Koshino, Hiroyuki

doi:10.1016/j.fitote.2012.03.024

Cited by 36 publications

(33 citation statements)

References 25 publications

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“…It is noteworthy that taxodione (C) inhibited Ca 2+ -signal transduction. The prospects of natural terpenoids that showed inhibitory activity towards Ca 2+ -signal transduction in the mutant strain of S. cerevisiae (zds1Δ erg3Δ pdr1Δ pdr3Δ) were discussed in our previous studies [19] [20]. Furthermore, taxodione (C) was the only compound to show potent inhibitory activity against PP2C with an IC 50 value of 56.4 μM.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from <i>Taxodium distichum</i> Cones

Kusumoto¹,

Aburai²,

Ashitani³

et al. 2014

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Eight naturally occurring diterpenoids, including 6,7-dehydroroyleanone, taxodal, taxodione, salvinolone, 14-deoxycoleon U, 5,6-dehydrosugiol, sandaracopimaric acid, and xanthoperol were isolated from Taxodium distichum cones and their biological properties evaluated in vitro against six different biological screening targets. Taxodione showed potent activity against a number of different targets, and salvinolone and 14-deoxycoleon U showed remarkable inhibitory activities against prolyl oligopeptidase (POP) and 17α-hydroxylase/C 17,20-lyase (CYP17), respectively. These three compounds also showed strong cytotoxic activities against HL60 and K562 human leukemia cells. The structure-activity relationships of these compounds have also been considered. The findings in this study could lead to enhanced pharmacological prospects for the natural abietanetype diterpenoids consisting in conifer cones.

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Section: Discussionmentioning

confidence: 99%

Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from <i>Taxodium distichum</i> Cones

Kusumoto¹,

Aburai²,

Ashitani³

et al. 2014

ABC

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“…[25] Aside from the proteins already mentioned, which are specific to the different UPR pathways, there are several proteins that are associated with more than one of the UPR pathways or other cellular pathways that may be associated with ER stress (Table 4). [25,30,33,44,[102][103][104][105][106][107][108][109] Is there a role for terpenoids from medicinal plants in alleviating endoplasmic reticulum stress and metabolic disorders?…”

Section: Thapsigargin Also Classified As a Guaianementioning

confidence: 99%

“…Kujigamberol is also cytotoxic to the promyelocytic leukemia cell line HL60. [33] Cannabidiol (CBD) Dehydrocostuslactone (DHE) CHOP Both terpenoids up-regulates the expression of the pro-apoptotic protein CHOP via the phosphorylation of PERK and the activation of the PERK signalling cascade in the hepatic stellate cells LX-2 and A549 cell lines and lung cancer cell line, NCI-H460, and the multiple myeloma cells OPM2. MM.1S.…”

Section: Dehydrocostuslactonev (Dhe) Genipinmentioning

confidence: 99%

“…Various terpenoids have been identified for their potential and promising role in treating diseases [25,30,33,44,[102][103][104][105][106][107][108][109] (Table 4). ER dysfunction has been documented to be linked to a variety of different diseases including lung diseases, cancers, diabetes and diabetic-related diseases/complications, malaria, neurological diseases, inflammatory diseases, viral infections etc.…”

Section: Dehydrocostuslactonev (Dhe) Genipinmentioning

confidence: 99%

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Selected terpenoids from medicinal plants modulate endoplasmic reticulum stress in metabolic disorders

Beukes

Levendal

Frost

2014

Journal of Pharmacy and Pharmacology

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Objectives The majority of research performed on cellular stress and apoptosis focuses on mitochondrial dysfunction; however, the importance of the endoplasmic reticulum dysfunction and the link to metabolic diseases has gained a substantial interest. This review focuses on the potential of terpenoids to influence endoplasmic reticulum stress and the possible role terpenoids play as the treatment of metabolic diseases. Key findings Metabolic diseases develop as a result of a cascade of cellular pathways. In most cases, cells are able to compensate for the disruption of the cellular homeostasis although the initiation of response pathways; however, chronic stress initiates apoptotic pathways. This reviewed (1) showed the importance of phytoterpenoids to influence endoplasmic reticulum (ER) stress and homeostasis, (2) showed how regulating ER stress affect the cell survival and death, and (3) highlighted some examples of how the progression of metabolic diseases can be influenced by ER. Summary Due to the substantial number of terpenoids that have been identified in literature, this review gave examples of 21 terpenoids that have been documented to have an effect on the different proteins associated with ER stress, how these plant terpenoids influence ER dysfunction and metabolic diseases such as diabetes, cancer, liver, and neurological diseases and parasitic infections.

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“…It is important to determine the color and quality of amber depending on its applications; however, the discrimination is done with the human eyes presently. A new compound, named kujigamberol, has been isolated from amber . Further, a regenerated amber, with 100% purity, has been achieved from pieces of amber .…”

Section: Introductionmentioning

confidence: 99%

Method to estimate colors of amber debris

Kageyama

Ishikawa

Ishizawa

et al. 2018

IEEJ Transactions Elec Engng

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This letter first demonstrates the color features of ambers and then a method to estimate their colors. The RGB (Red, Green, and Blue) color space and the HSV (Hue, Saturation, and Value) color space are used for data analysis. Four kinds of ambers: three of different colors (yellow, brown, and black) and an amber with an outer cover (AOC) created by solid resin or amber dirt are examined. The proposed method consists of masking, detection of AOC, and an estimation of amber colors. Experimental results for 185 images show that the proposed method can estimate amber colors with an accuracy of 90.3%. It is also shown that the yellow color is perfectly distinguished, and that the estimation accuracy of the three colors is 98.0%.

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Kujigamberol, a new dinorlabdane diterpenoid isolated from 85million years old Kuji amber using a biotechnological assay

Cited by 36 publications

References 25 publications

Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from <i>Taxodium distichum</i> Cones

Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from <i>Taxodium distichum</i> Cones

Selected terpenoids from medicinal plants modulate endoplasmic reticulum stress in metabolic disorders

Method to estimate colors of amber debris

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Kujigamberol, a new dinorlabdane diterpenoid isolated from 85million years old Kuji amber using a biotechnological assay

Cited by 36 publications

References 25 publications

Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from &lt;i&gt;Taxodium distichum&lt;/i&gt; Cones

Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from &lt;i&gt;Taxodium distichum&lt;/i&gt; Cones

Selected terpenoids from medicinal plants modulate endoplasmic reticulum stress in metabolic disorders

Method to estimate colors of amber debris

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Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from <i>Taxodium distichum</i> Cones

Pharmacological Prospects of Oxygenated Abietane-Type Diterpenoids from <i>Taxodium distichum</i> Cones