Kumada–Corriu reactions in a pressure-driven microflow reactor

Abstract

Reaction rates for the Kumada reaction (of Grignard reagents with aryl halides) catalysed by an immobilised nickel(II) catalyst have been shown to be enhanced when the reaction is carried out in a pressure driven microreactor (internal diameter 100-200 microm) rather than with conventional batch reaction techniques.

Chemistry in Microstructured Reactors

“…[173][174][175] The silica-etched channels were either 500 or 1000 mm wide and had a depth of 250 mm and a length of 33 mm. Growth of the TS-1 crystals occurred in the open structures, the surfaces of which were initially treated with 3-(trimethoxysilyl)propylthiol to improve the adhesion of TS-1.…”

“…[74,207,235] Zeolites are another class of industrially used catalysts that can be directly grown into microchannels. [173,174,236] The anodic oxidation of aluminum channels is frequently used in order to generate nanoporous carrier layers. [213] Thin-film technologies such as CVD [207] and PVD (especially sputtering [231] ) can be used to generate compact, thin catalyst films.…”

Micro reactors: principles and applications in organic synthesis

“…O'Sullivan et al 69 have recently investigated the Kumada± Corriu reaction in a pressure-driven micro reactor. The reactor was constructed by placing a plug of catalyst into a length of polypropylene tubing.…”

Chemie in Mikrostrukturreaktoren

“…Zeolithe, eine wichtige Klasse industrieller Katalysatoren, kann man direkt im Mikrokanal aufwachsen lassen. [173,174,236] Die anodische Oxidation wird häufig genutzt, um nanoporöse Trägerschichten in Aluminiumkanälen zu erzeugen. [207,213] Dünnschichttechniken wie CVD [207] und PVD sowie Sputtern [231] ergeben kompakte, dünne Katalysatorfilme.…”

“…Die Herstellung von Katalysator/Träger-Systemen in Mikrokanälen ist besonders detailliert für Washcoats [74,235] und für das Zeolithwachstum [173,174,236] beschrieben worden. Katalysatoren werden gewöhnlich durch Einfüllen und Abwischen von Washcoats aufgezogen ("Fill-in-Wipe-off"-Methode).…”