Kumada cross coupling reaction based synthesis, antimicrobial and computational studies of 6-aryl-2-phenyl-3-methylquinazolin-4(3H)-ones

Shankaraiah, P.; Veeresham, S.; Bhavani, A. K. D.

doi:10.1134/s1070363216020286

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Cited by 3 publications

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“…6-Iodo-3-methyl-2-phenylquinazolin-4(3H)-one (1), the key material for quinazolin-4(3H)-one based internal alkynes, was prepared using a reported procedure 20 (Scheme 1). At the outset, only a few reports were available for the preparation of quinazolin-4(3H)-one based internal alkynes.…”

Section: Resultsmentioning

confidence: 99%

PEG mediated synthesis of 6-pyrazinyl-/fused pyrazinylquinazolin-4(3H)-ones using Castro-Stephen coupling, oxidation and cyclocondensation reactions

Pagilla¹,

Kumar²,

Sunitha

et al. 2020

JSCS

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Section: Resultsmentioning

confidence: 99%

PEG mediated synthesis of 6-pyrazinyl-/fused pyrazinylquinazolin-4(3H)-ones using Castro-Stephen coupling, oxidation and cyclocondensation reactions

Pagilla¹,

Kumar²,

Sunitha

et al. 2020

JSCS

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Advances in Kumada–Tamao–Corriu cross-coupling reaction: an update

et al. 2019

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The formation of the CC bond is a major and important reaction in synthetic organic chemistry and frequently catalyzed by transition-metal catalysts. Among them, Kumada-Tamao-Corriu coupling reaction is providing a simple methodology and extensively employed in the art of organic synthesis. In this review, we try to highlight the recent advances in the applications of Kumada-Tamao-Corriu coupling reaction by updating of our previous review from 2012 up to date.

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Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph₃P–I₂

2017

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Readily available N-substituted amides or their requisite carboxylic acids or acid chlorides have been used to construct 2,3-disubstituted-3H-quinazolin-4-ones in a one-pot procedure. Key transformation in this convergent approach involves PhP-I-mediated formation of amidine upon condensation of an amide or the intermediate amide with methyl anthranilate. Cyclization of the amidine-tethered anthranilate then affords 2,3-disubstituted-3H-quinazolin-4-ones in good to excellent yields under mild conditions.

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Kumada cross coupling reaction based synthesis, antimicrobial and computational studies of 6-aryl-2-phenyl-3-methylquinazolin-4(3H)-ones

Cited by 3 publications

References 21 publications

PEG mediated synthesis of 6-pyrazinyl-/fused pyrazinylquinazolin-4(3H)-ones using Castro-Stephen coupling, oxidation and cyclocondensation reactions

PEG mediated synthesis of 6-pyrazinyl-/fused pyrazinylquinazolin-4(3H)-ones using Castro-Stephen coupling, oxidation and cyclocondensation reactions

Advances in Kumada–Tamao–Corriu cross-coupling reaction: an update

Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph₃P–I₂

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Kumada cross coupling reaction based synthesis, antimicrobial and computational studies of 6-aryl-2-phenyl-3-methylquinazolin-4(3H)-ones

Cited by 3 publications

References 21 publications

PEG mediated synthesis of 6-pyrazinyl-/fused pyrazinylquinazolin-4(3H)-ones using Castro-Stephen coupling, oxidation and cyclocondensation reactions

PEG mediated synthesis of 6-pyrazinyl-/fused pyrazinylquinazolin-4(3H)-ones using Castro-Stephen coupling, oxidation and cyclocondensation reactions

Advances in Kumada–Tamao–Corriu cross-coupling reaction: an update

Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph3P–I2

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Approach to the Synthesis of 2,3-Disubstituted-3H-quinazolin-4-ones Mediated by Ph₃P–I₂