1981
DOI: 10.1007/bf02815801
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Kupffer cell hyperplasia in liver diseases. demonstration by scanning electron microscopy of biopsy samples

Abstract: Kupffer cells were observed in liver biopsy tissues of 9 cases of liver diseases by scanning electron microscopy to prove Kupffer cell proliferation numerically. Kupffer cell count per 0.01 mm2 of cracked surface of liver lobule was 1.2 +/- 0.3 in the convalescent stage of a mild acute hepatitis case and 1.2 +/- 0.1 in a chronic persistent hepatitis case with slight inflammation. Whereas it was increased to 2.4-5.5 (P less than 0.01) in the convalescent stage of moderate to severe acute hepatitis cases, 1.8 +/… Show more

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Cited by 9 publications
(5 citation statements)
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“…19 However, studies on AIH in this field are scarce. 10,14,20 Himoto et al 20 denied the diagnostic significance of KCHGs to be specific in AIH. Recently, a modified scoring system for the diagnosis of AIH was developed by Gurung et al 2018 21 in which "typical" features require both the presence of prominent plasma cells and KCHGs, while "Compatible" features included prominent plasma cells but lack KCHGs.…”
Section: Discussionmentioning
confidence: 99%
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“…19 However, studies on AIH in this field are scarce. 10,14,20 Himoto et al 20 denied the diagnostic significance of KCHGs to be specific in AIH. Recently, a modified scoring system for the diagnosis of AIH was developed by Gurung et al 2018 21 in which "typical" features require both the presence of prominent plasma cells and KCHGs, while "Compatible" features included prominent plasma cells but lack KCHGs.…”
Section: Discussionmentioning
confidence: 99%
“…12 Kupffer cells (KCs) hyperplasia was demonstrated in liver tissue of children with AIH, although the function that these cells play was unknown in the disease process. 13,14 Immunoglobulin's deposition was demonstrated in the cytoplasm of KCs in AIH over 50 years ago by immunofluorescence techniques. 14 These reports, on the other hand, did not mention any distinctive inclusions in KCs on hematoxylin and eosin (H&E) stained parts or any other special stains.…”
mentioning
confidence: 99%
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“…Quantitative analysis of Kupffer cells in the human liver has not been reported, although there have been some studies on Kupffer cells in normal and pathological rat liver (21,22). Morphometry of Kupffer cells positive for the PNA lectin demonstrated that Kupffer cells in chronic aggressive hepatitis showed the highest percent area, although the number of patients studied in this paper was small.…”
Section: Computer Image Analysismentioning
confidence: 99%
“…Kupffer cells, the primary phagocytic cells of the liver (2,10), play a key role in the removal of blood or gut-derived foreign materials (2,7). Although activation and/or hyperplasia of Kupffer cells are commonly seen under various conditions that stimulate the reticuloendothelial system (4,6,9,17,22,24), targeted toxicity of Kupffer cells is very rare (1). However, multinuclear transformation ofKupffer cells is not uncommon when inert particulate materials such as zymosan, thorotrast, methylcellulose, glucan, or india ink are administered to experimental animals parenterally (3,4,26).…”
Section: Introductionmentioning
confidence: 99%