Kuromoji (<i>Lindera umbellata</i>) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Maeda, Hayato; Yamazaki, Mao; Katagata, Yohtaro

doi:10.1271/bbb.120692

Cited by 23 publications

(18 citation statements)

References 35 publications

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“…Previously, linalool has been reported to inhibit VEGF and TGF-β1 expression in different experimental models. [35][36][37] Linalool possessed the strongest inhibitory activity against various carcinoma cells. 18,38 Apoptosis is a controlled mechanism which limits the survival of cells with irreparable cellular damage and avoids malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice

Gunaseelan

Balupillai

Kanimozhi

et al. 2016

Photochem Photobiol Sci

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In this study, we evaluated the role of linalool in acute ultraviolet-B (UVB; 280-320 nm) radiation-induced inflammation and chronic UVB-mediated photocarcinogenesis in mouse skin. Acute UVB-irradiation (180 mJ cm(-2)) causes hyperplasia, edema formation, lipid peroxidation, antioxidant depletion, and overexpression of cyclooxygenase-2 (COX-2) and ornithine decarboxylase (ODC) in mouse skin. Topical or intraperitoneal (i.p.) treatment of linalool prevented acute UVB-induced hyperplasia, edema formation, lipid peroxidation, and antioxidant depletion in mouse skin. Further, linalool treatment prevented UVB-induced overexpression of COX-2 and ODC in mouse skin. In the chronic study, mice were subjected to UVB-exposure thrice weekly for 30 weeks. Chronic UVB-exposure induced tumor incidence and expression of proliferative markers such as NF-κB, TNF-α, IL-6, COX-2, VEGF, TGF-β1, Bcl-2 and mutated p53 in mouse skin. Treatment with linalool before each UVB-exposure significantly prevented the expression of these proliferative markers and subsequently decreased the tumor incidence in mice skin. Histopathological studies confirmed the development of dysplasia and squamous cell carcinoma (SCC) in the chronic UVB-exposed mouse skin; and this was prevented by both topical and i.p. linalool treatment. Therefore, linalool may be considered as a photochemopreventive agent against UVB radiation induced skin carcinogenesis.

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Section: Discussionmentioning

confidence: 99%

The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice

Gunaseelan

Balupillai

Kanimozhi

et al. 2016

Photochem Photobiol Sci

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“…Essential oil suppressed LPS-induced pro-inflammatory cytokine production such as that of NO, IL-6, and TNF-α in a dosedependent manner. In addition, iNOS and cyclooxygenase-2 mRNA expression and protein levels were suppressed by treatment with KEO cells [19]. Cannabidiol (CBD) was isolated from flax fabric extract.…”

Section: Boswellia Ovalifoliolatamentioning

confidence: 99%

“…Histopathological analysis demonstrated that both of hydroalcoholic extract and its ethyl acetate fraction had comparable antiarthritic activity with methotrexates [39]. The 19-nor-clerodane trans-crotonin (CTN) (19) and the triterpene acetyl aleuritolic acid (AAA) (20) isolated from the stem bark of Croton cajucara Benth. Compound showed exhibited significant inhibition in the dextran-induced edema 90 minutes after the stimulus: 31.9% for CTN and 28.5% for AAA.…”

Section: Fig 2: Structures Of Compounds Having Anti-inflammatory Potmentioning

confidence: 99%

Terpenoids as Source of Anti-Inflammatory Compounds

Prakash

2017

Asian J Pharm Clin Res

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Terpenoids accounts for the major class of secondary metabolites produced by plants. It shows defense activity against environmental stress and help to heal injuries. Medicinal plants are rich in monoterpenoids, diterpenoids, sesquiterpenes, triterpenes, tetraterpenes, and ceramide. A number of therapeutic applications such as antibacterial, antimicrobial, antitumor, anti-inflammatory activity have been identified. Terpenoids are compounds similar to terpenes derived from 5-carbon monomer isoprene units. The review puts and detail insight on different class of compounds isolated from natural source from 2000 to 2016 showing anti-inflammatory potential of pharmacologically interesting agent and their mechanism of action.

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“…Flavonoids have also reportedly been isolated from several Lindera plants including Lindera umbellata, Lindera lucida, Lindera erythrocarpa, Lindera aggregata, and Lindera obtusiloba [7,8]. Lindera plants and isolated compounds have been studied for different biological activities including cytotoxic [9,10], anti-inflammatory [11,12], anti-hypertensive [13], hepatoprotective [14], and antioxidant activities [15,16].…”

Section: Introductionmentioning

confidence: 99%

Extraction and Isolation of Kaempferol Glycosides from the Leaves and Twigs of Lindera neesiana

et al. 2019

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The hydroalcoholic extract of leaves and twigs of Lindera neesiana (Wall. ex Nees) Kurz (Lauraceae) was subjected to various column chromatographic methods that isolated five kaempferol glycosides: kaempferol 3-O-β-glucopyranosyl(1→2)-[α-rhamnopyranosyl-(1→6)]-β- glucopyranoside-7-O-α-rhamnopyranoside (1); kaempferol 3-O-β-glucopyranosyl-(1→2)-[α-rhamnopyranosyl (1→6)]-β-glucopyranoside (2); kaempferol 3-O-β-glucopyranosyl(1→2)- α-rhamnopyranoside-7-O-α-rhamnopyranoside (3); kaempferol 3-O-sophoroside (4); and kaempferol 3-O-α-rhamnopyranoside (5). The extract showed moderate free radical scavenging activity and potent pancreatic lipase inhibitory activity.

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Kuromoji (Lindera umbellata) Essential Oil Inhibits LPS-Induced Inflammation in RAW 264.7 Cells

Cited by 23 publications

References 35 publications

The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice

The preventive effect of linalool on acute and chronic UVB-mediated skin carcinogenesis in Swiss albino mice

Terpenoids as Source of Anti-Inflammatory Compounds

Extraction and Isolation of Kaempferol Glycosides from the Leaves and Twigs of Lindera neesiana

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