Kurzzeit-Immuntherapie mit Baumpollen-Allergoiden und dem Adjuvans Monophosphoryl Lipid-A – Ergebnisse einer randomisierten, doppelblinden, plazebokontrollierten Multicenterstudie

Guideline on allergen immunotherapy in IgE-mediated allergic diseases

“…In a series of DBPC studies on the efficacy of AIT on birch pollen allergies, a reduction in symptoms and/or medication use was shown for some preparations [ 98 , 151 , 152 , 153 , 154 , 155 , 156 ]. On the contrary, the safety and efficacy of many other marketed birch pollen extracts have never been demonstrated in DBPC trials.…”

MicroCrystalline Tyrosine-adsorbed immunotherapy

“…It can be anticipated that this fully biodegradable adjuvants will also in future studies not reveal side effects [72]. All available data demonstrate a convincing overall safety and tolerability profile for MCT-adsorbed immunotherapy products: In 43 studies using pollen Allergoid-MCT [ [22,29,38,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57], no treatment-related serious adverse events have been reported. ].…”

“…Since their inception in the 1970s, more than 100 published studies have been conducted with Allergoid-MCT-based AIT in over 17 000 patients [22,29,33 ▪ ,38,41–57,58 ▪▪ ,59 ▪ ,60 ▪ ,61–63,64 ▪▪ ,65,66]. These studies include a wide and heterogeneous variety of allergen extracts (including grass, trees, weeds and mites), product platforms (including Allergoid-MCT and PQ) and study designs (including DBPC trials, biomarker studies, noncontrolled studies, noninterventional studies and investigator-initiated research).…”

Evolution of subcutaneous allergen immunotherapy (part 1): from first developments to mechanism-driven therapy concepts

“…Since the proportion of children and adolescents was so low, no age group-specific analysis was performed. SCIT using a tree pollen allergoid with an MPL adjuvant was carried out in a further DBPC study on 84 adult patients sensitized to birch, alder, and hazel pollen [49]. SCIT was performed as preseasonal short-term treatment consisting of four injections at 1-week intervals.…”