Kutane B-Zell-Lymphome

Gellrich, Sylke; Muche, J. Marcus; Audring, Heike; Sterry, Wolfram

doi:10.1007/s001050051136

Cited by 3 publications

(2 citation statements)

References 8 publications

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“…Persistent antigenic stimulation of lymphocytes can lead to transformation and cell division with the development of large blast cells. [14,15] stage B lymphocytes but with a larger number of T lymphocytes Antigen-associated transformation and further somatic mutation have been described as "T-cell-rich B-cell lymphoma." [10] These can account for PCBCL associated with Borrelia infection (figure cases appear to represent PCFCL or primary cutaneous marginal 4).…”

Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Follicle Center Lymphoma ??? ???Crosti Lymphoma???

Ziemer

Bauer

Fluhr

et al. 2008

American Journal of Clinical Dermatology

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In 1951, Crosti reported on seven patients with 'reticulo-histiocytoma of the back' who presented with figurate erythematous plaques and nodules on the back or lateral trunk. Reticulo-histiocytoma of the back was later classified as a primary cutaneous follicle center lymphoma (PCFCL). A definitive diagnosis of the condition is frequently delayed because of a relative lack of clinical symptoms and difficulties in interpretation of the histologic findings. Indeed, a number of primary cutaneous B-cell lymphomas have been mislabeled as pseudolymphomas in the past. We present a case of PCFCL that initially demonstrated predominantly small T lymphocytes on histology. These findings were interpreted as an inflammatory pseudolymphomatous reaction. However, small lymphocytes, whether B or T cells, in early lesions of cutaneous B-cell lymphomas should not automatically be considered 'reactive.' Persistent antigenic stimulation of lymphocytes in a neoplastic process or by an antigen, for example, Borrelia burgdorferi, can lead to transformation and cell division with development of large blast cells. In our patient, the initial scarcity of B lymphocytes also led to further diagnostic difficulties. Although the association of primary cutaneous B-cell lymphoma with Borrelia infection is known, there are still difficulties in differentiating the condition from pseudolymphoma. Such difficulties can in part be ascribed to the morphologic changes such lymphomas can undergo over time. The initially small number of B cells that may be seen at first in PCFCL infiltrates may increase in number in longer-standing lesions. It is also important to recognize that inability to verify monoclonality should not exclude the diagnosis of lymphoma.

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Section: Discussionmentioning

confidence: 99%

Primary Cutaneous Follicle Center Lymphoma ??? ???Crosti Lymphoma???

Ziemer

Bauer

Fluhr

et al. 2008

American Journal of Clinical Dermatology

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“…Betrachtet man die Häufigkeit des Studieneinschlusses im Rahmen einer Rezidivtherapie, zeigt sich, dass 22 Patienten (25,9%) in eine Studie eingeschlossen werden konnten. Trennt man das Patientenkollektiv der 85 Patienten mit Rezidivtherapie in junge und ältere Patienten, ergibt sich folgendes Bild:Klinik, Prognose und Therapie bei diesen Subentitäten unterscheiden(Gellrich et al 2000, Deckert et al 2011. Weitere Ausschlusskriterien waren der frühzeitige Wechsel in eine andere Therapieeinrichtung (n=21; 9,1%) oder das Ablehnen der weiteren Therapie, was einen Therapieabbruch zur Folge hatte (n=2; 0,9%).…”

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Inzidenz, Therapie und Therapieerfolg bei Lymphomen und Leukämieerkrankungen in der Abteilung Hämatologie und Onkologie der Universitätsmedizin Göttingen unter besonderer Berücksichtigung des Anteils von Studienpatienten in den Jahren 2004-2009

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Rezidiv-/Salvagetherapie 4 DISKUSSION 4.1 Epidemiologie und Häufigkeit des Studieneinschlusses des Göttinger Patientenkollektivs 4.1.1 Aggressive B-und T-Zell-Lymphome 4.1.2 Indolente B-und T-Zell-Lymphome 4.1.3 Hodgkin-Lymphom 4.1.4 Plasmozytome 4.1.5 Leukämien 4.2 Das DLBCL-Patientenkollektiv 4.3 Klinische Ergebnisse der Göttinger DLBCL-Patienten im Vergleich mit Studien 4.3.1 Junge Patienten mit guter Prognose (aaIPI<2) und die MInT-Studie 4.3.2 Junge Patienten mit schlechter Prognose (aaIPI≥2) und die MegaCHOEP-Studie 4.3.3 Ältere Patienten und die RICOVER-60-Studie 4.4 Rezidivpatienten und die CORAL-Studie

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Disseminated Cutaneous B-cell Lymphoma Mimicking Pseudolymphoma over a Period of Six Years

Gutermuth

Audring

Roseeuw³

2004

The American Journal of Dermatopathology

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We describe a patient with a disseminated nodular cutaneous B-cell lymphoma, whose diagnosis was finally made after a long series of biopsies in different institutions in Europe and the United States. The differential diagnosis between lymphoma and pseudolymphoma was the recurrent problem throughout the patient's history because histologic and immunophenotypic criteria alone were not sufficient for differentiation. Molecular biology inconsistently detected clonal immunoglobulin rearrangements, which proves that careful clinicopathologic correlation remains mandatory. In contrast to a claimed "high-grade" malignant histology, this lymphoma responded with remission to PUVA therapy combined with intralesional corticosteroids, which is uncommon in the management of cutaneous B-lymphomas.

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Kutane B-Zell-Lymphome

Cited by 3 publications

References 8 publications

Primary Cutaneous Follicle Center Lymphoma ??? ???Crosti Lymphoma???

Primary Cutaneous Follicle Center Lymphoma ??? ???Crosti Lymphoma???

Inzidenz, Therapie und Therapieerfolg bei Lymphomen und Leukämieerkrankungen in der Abteilung Hämatologie und Onkologie der Universitätsmedizin Göttingen unter besonderer Berücksichtigung des Anteils von Studienpatienten in den Jahren 2004-2009

Disseminated Cutaneous B-cell Lymphoma Mimicking Pseudolymphoma over a Period of Six Years

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