Kuwanon T and Sanggenon a Isolated from Morus alba Exert Anti-Inflammatory Effects by Regulating NF-κB and HO-1/Nrf2 Signaling Pathways in BV2 and RAW264.7 Cells

Ko, Wonmin; Liu, Zhiming; Kim, Kwan-Woo; Dong, Linsha; Lee, Hwan; Kim, Na Young; Lee, Dong-Sung; Woo, Eun‐Rhan

doi:10.3390/molecules26247642

Cited by 7 publications

(6 citation statements)

References 54 publications

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“…The quantification of the phenolic compounds in the ethyl acetate fraction, which had the highest ACE enzyme inhibition effect, was conducted using UPLC-DAD-QToF/MS. Kuwanon G and H, which are prenylated flavonoids, were confirmed as the predominant compounds in the ethyl acetate fraction of the root bark (Figure 4) [33,34]. The contents of these compounds (mg/g of extract) were distributed differently according to the cultivar type (Cheongol, Cheongil, Daeshim, and Gwasang2).…”

Section: Quantification Of Kuwanon G and Kuwanon H In Root Bark And T...mentioning

confidence: 95%

Modulatory Effects of the Kuwanon-Rich Fraction from Mulberry Root Bark on the Renin–Angiotensin System

Lee,

Kim,

Kim

et al. 2024

Foods

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In this study, we investigated the anti-hypertensive properties of mulberry products by modulating the renin–angiotensin system (RAS). Comparative analysis showed that the ethyl acetate fractions, particularly from the Cheongil and Daeshim cultivars, contained the highest levels of polyphenols and flavonoids, with concentrations reaching 110 mg gallic acid equivalent (GE)/g and 471 mg catechin equivalent (CE)/g of extract, respectively. The ethyl acetate fraction showed superior angiotensin-converting enzyme (ACE) inhibitory activity, mainly because of the presence of the prenylated flavonoids kuwanon G and H. UPLC/Q-TOF-MS analysis identified kuwanon G and H as the primary active components, which significantly contributed to the pharmacological efficacy of the extract. In vivo testing of mice fed a high-salt diet showed that the ethyl acetate fraction substantially reduced the heart weight and lowered the serum renin and angiotensinogen levels by 34% and 25%, respectively, highlighting its potential to modulate the RAS. These results suggested that the ethyl acetate fraction of mulberry root bark is a promising candidate for the development of natural ACE inhibitors. This finding has significant implications for the management of hypertension through RAS regulation and the promotion of cardiovascular health in the functional food industry.

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Section: Quantification Of Kuwanon G and Kuwanon H In Root Bark And T...mentioning

confidence: 95%

Modulatory Effects of the Kuwanon-Rich Fraction from Mulberry Root Bark on the Renin–Angiotensin System

Lee,

Kim,

Kim

et al. 2024

Foods

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“…In addition, oxyresveratrol was alos reported favourable anti-inflammatory effect through the inhibitions of iNOS/NO production, synthesis of PGE2 and activation of NF-κB(Chung et al, 2003). The methanol extraction of mulberry bark showed that components named kuwanon T and sanggenon A in mulberry bark contribute to the anti-inflammatory activities on microglia (BV2) and macrophages (RAW264.7) by the inhibitions of productions of prostaglandin E2, interleukin-6 and tumour necrosis factor-α, and the stimulation of expression of cyclooxygenase-2 ( Ko et al, 2021 ). The anti-inflammatory active ingredients in mulbery are displayed in Table 10 .…”

Section: The Pharmacological Activities Of Components In Mo...mentioning

confidence: 99%

“…Sanggenol L, another natural flavonoid compound in Mori cortex, could induce the apoptosis through inhibiting the PI3K/Akt/mTOR signaling pathway, and accelerate the cycle arrest of prostate cancer cells by activating the p53 protein ( Won and Seo, 2020 ). In addition, sanggenol L could also reduce cytotoxicity and apoptosis in ovarian cancer cells through activating cysteine aspartase and inhibiting NF-κB ( Ko et al, 2021 ). Moracin N was an active ingredient in Mori folium, which exhibit anti-lung cancer properties through apoptosis and autophagy ( Gao C. et al, 2020 ).…”

Section: The Pharmacological Activities Of Components In Mo...mentioning

confidence: 99%

Comprehensive overview of different medicinal parts from Morus alba L.: chemical compositions and pharmacological activities

Wang,

Ai,

et al. 2024

Front. Pharmacol.

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Morus alba L., a common traditional Chinese medicine (TCM) with a centuries-old medicinal history, owned various medicinal parts like Mori folium, Mori ramulus, Mori cortex and Mori fructus. Different medical parts exhibit distinct modern pharmacological effects. Mori folium exhibited analgesic, anti-inflammatory, hypoglycemic action and lipid-regulation effects. Mori ramulus owned anti-bacterial, anti-asthmatic and diuretic activities. Mori cortex showed counteraction action of pain, inflammatory, bacterial, and platelet aggregation. Mori fructus could decompose fat, lower blood lipids and prevent vascular sclerosis. The main chemical components in Morus alba L. covered flavonoids, phenolic compounds, alkaloids, and amino acids. This article comprehensively analyzed the recent literature related to chemical components and pharmacological actions of M. alba L., summarizing 198 of ingredients and described the modern activities of different extracts and the bioactive constituents in the four parts from M. alba L. These results fully demonstrated the medicinal value of M. alba L., provided valuable references for further comprehensive development, and layed the foundation for the utilization of M. alba L.

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“…Sappanone A is a homoisoflavanone that exerts a mitigating effect on allergic airway inflammation in ovalbumin-induced asthma. In addition, sappanone A significantly inhibited LPS (HY-D1056)-induced nitric oxide production and exerted its anti-inflammatory effects by modulating NF-κB and heme oxygenase 1(HO-1)/nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathways in BV2 and RAW264.7 cells [119]. Pectolinarin exerts its anti-inflammatory effects by inhibiting the secretion of IL-6 and IL-8 and the production of PGE2 and nitric oxide (NO).…”

Section: Anti-inflammatory and Analgesic Effectsmentioning

confidence: 99%

Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives

Hao,

Yang,

Liu

et al. 2024

CIMB

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At present, the occurrence of a large number of infectious and non-communicable diseases poses a serious threat to human health as well as to drug development for the treatment of these diseases. One of the most significant challenges is finding new drug candidates that are therapeutically effective and have few or no side effects. In this respect, the active compounds in medicinal plants, especially flavonoids, are potentially useful compounds with a wide range of pharmacological activities. They are naturally present in nature and valuable in the treatment of many infectious and non-communicable diseases. Flavonoids are divided into fourteen categories and are mainly derived from plant extraction, chemical synthesis and structural modification, and biosynthesis. The structural modification of flavonoids is an important way to discover new drugs, but biosynthesis is currently considered the most promising research direction with the potential to revolutionize the new production pipeline in the synthesis of flavonoids. However, relevant problems such as metabolic pathway analyses and cell synthesis protocols for flavonoids need to be addressed on an urgent basis. In the present review, new research techniques for assessing the biological activities of flavonoids and the mechanisms of their biological activities are elucidated and their modes of interaction with other drugs are described. Moreover, novel drug delivery systems, such as nanoparticles, bioparticles, colloidals, etc., are gradually becoming new means of addressing the issues of poor hydrophilicity, lipophilicity, poor chemical stability, and low bioavailability of flavonoids. The present review summarizes the latest research progress on flavonoids, existing problems with their therapeutic efficacy, and how these issues can be solved with the research on flavonoids.

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Kuwanon T and Sanggenon a Isolated from Morus alba Exert Anti-Inflammatory Effects by Regulating NF-κB and HO-1/Nrf2 Signaling Pathways in BV2 and RAW264.7 Cells

Cited by 7 publications

References 54 publications

Modulatory Effects of the Kuwanon-Rich Fraction from Mulberry Root Bark on the Renin–Angiotensin System

Modulatory Effects of the Kuwanon-Rich Fraction from Mulberry Root Bark on the Renin–Angiotensin System

Comprehensive overview of different medicinal parts from Morus alba L.: chemical compositions and pharmacological activities

Advances in Flavonoid Research: Sources, Biological Activities, and Developmental Prospectives

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