Kv1.3 in the spotlight for treating immune diseases

Navarro-Pérez, María; Capera, Jesusa; Benavente-Garcia, Anna; Cassinelli, Silvia; Colomer-Molera, Magalí; Felipe, Antonio

doi:10.1080/14728222.2024.2315021

Expert Opinion on Therapeutic Targets

2024

DOI: 10.1080/14728222.2024.2315021

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Kv1.3 in the spotlight for treating immune diseases

María Navarro-Pérez,

Jesusa Capera,

Anna Benavente-Garcia

et al.

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2024

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Cited by 2 publications

References 186 publications

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Do KATP channels have a role in immunity?

Feske,

Colucci,

Coetzee

2024

Front. Immunol.

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Ion channels, exchangers and pumps are expressed ubiquitously in cells from all phyla of life. In mammals, their role is best described in excitable cells, where they regulate the initiation and propagation of action potentials. There are over 70 different types of K+ channels subunits that contribute to these processes. In non-excitable cells, K+ channels set the resting membrane potential, which in turn drives the activity of other translocators. K+ channels also help maintain cell volume, influence cell proliferation and apoptosis and regulate Ca2+ signaling, which in turn is crucial for many cellular processes, including metabolism, secretion, and gene expression. K+ channels play crucial roles in the activation, proliferation and a variety of other functions in cells of the innate and adaptive immune system. The ATP-sensitive K+ (KATP) channel has an established role in diverse cells, but its presence and function in immunity is scantly described. Public gene expression databases show that KATP channel subunits are highly expressed in NKT and NK cells, and that they are significantly upregulated after infection in CD8+ T cells and macrophages. We discuss these findings in the light of the available literature and propose a role for KATP channels in cytotoxicity of cells that are primed for a rapid immune response. Possible underlying molecular mechanisms are discussed.

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Do KATP channels have a role in immunity?

Feske,

Colucci,

Coetzee

2024

Front. Immunol.

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Revealing the Diversity of Sequences, Structures, and Targets of Peptides from South China Sea Macrodactyla doreensis Based on Transcriptomics

Hua,

Liao,

et al. 2024

Marine Drugs

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The South China Sea is rich in sea anemone resources, and the protein and peptide components from sea anemone toxins comprise an important treasure trove for researchers to search for leading compounds. This study conducted a comprehensive transcriptomic analysis of the tentacles and column of Macrodactyla doreensis and explored the distribution and diversity of proteins and peptides in depth using bioinformatics, initially constructing a putative protein and peptide database. In this database, typical peptide families are identified through amino acid sequence analysis, and their 3D structures and potential biological activities are revealed through AlphaFold2 modeling and molecular docking. A total of 4239 transcripts were identified, of which the putative protein accounted for 81.53%. The highest content comprised immunoglobulin and a variety of proteases, mainly distributed in the column and related to biological functions. Importantly, the putative peptide accounted for 18.47%, containing ShK domain and Kunitz-type peptides, mainly distributed in the tentacles and related to offensive predatory behavior. Interestingly, 40 putative peptides belonging to eight typical peptide families were identified, and their structures and targets were predicted. This study reveals the diversity and complexity of Macrodactyla doreensis toxins and predicts their structure and targets based on amino acid sequences, providing a feasible approach for research regarding the discovery of peptides with potentially high activity.

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Kv1.3 in the spotlight for treating immune diseases

Cited by 2 publications

References 186 publications

Do KATP channels have a role in immunity?

Do KATP channels have a role in immunity?

Revealing the Diversity of Sequences, Structures, and Targets of Peptides from South China Sea Macrodactyla doreensis Based on Transcriptomics

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