2021
DOI: 10.3389/fnins.2021.740378
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Kv4.2-Positive Domains on Dendrites in the Mouse Medial Geniculate Body Receive Ascending Excitatory and Inhibitory Inputs Preferentially From the Inferior Colliculus

Abstract: The medial geniculate body (MGB) is the thalamic center of the auditory lemniscal pathway. The ventral division of MGB (MGV) receives excitatory and inhibitory inputs from the inferior colliculus (IC). MGV is involved in auditory attention by processing descending excitatory and inhibitory inputs from the auditory cortex (AC) and reticular thalamic nucleus (RTN), respectively. However, detailed mechanisms of the integration of different inputs in a single MGV neuron remain unclear. Kv4.2 is one of the isoforms… Show more

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Cited by 3 publications
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“…Glutamatergic neurons in the inferior colliculus contribute to the AGS phenotype in Fmr1 mice ( Gonzalez et al, 2019 ). Axon terminals of VGLUT2-positive excitatory neurons extending from the inferior colliculus to multiple brain regions show high expression levels of DPP10 ( Fujimoto et al, 2021 ) that, compared to other FXS NPCs, was the most significantly increased transcript in HEL100.2 NPCs throughout the sampling period ( Figure 5C ). DPP10 interacts with the voltage-gated K+ channel 4 (Kv4) ( Ren et al, 2005 ), whose dysfunction has been associated with epilepsy ( Singh et al, 2006 ) and ASD with concomitant epilepsy ( Lin et al, 2018 ).…”
Section: Resultsmentioning
confidence: 99%
“…Glutamatergic neurons in the inferior colliculus contribute to the AGS phenotype in Fmr1 mice ( Gonzalez et al, 2019 ). Axon terminals of VGLUT2-positive excitatory neurons extending from the inferior colliculus to multiple brain regions show high expression levels of DPP10 ( Fujimoto et al, 2021 ) that, compared to other FXS NPCs, was the most significantly increased transcript in HEL100.2 NPCs throughout the sampling period ( Figure 5C ). DPP10 interacts with the voltage-gated K+ channel 4 (Kv4) ( Ren et al, 2005 ), whose dysfunction has been associated with epilepsy ( Singh et al, 2006 ) and ASD with concomitant epilepsy ( Lin et al, 2018 ).…”
Section: Resultsmentioning
confidence: 99%