2022
DOI: 10.2147/ndt.s377982
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KXS Balances the Tryptophan Metabolism in Mild to Moderate Depressed Patients and Chronic Restraint Stress Induced Depressive Rats

Abstract: Purpose Tryptophan metabolism is involved in the etiology and exacerbation of depressive disorders. Kai-Xin-San (KXS), a traditional Chinese medicine formula, has been widely used to treat depression and modulate serotonin simultaneously, but how it regulates depressive-like behavior by shifting the balance of the tryptophan-serotonin metabolism and kynurenine pathway remains vague. Patients and Methods Ten participants with mild to moderate depression treated with KXS … Show more

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Cited by 5 publications
(1 citation statement)
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“…It is composed of Polygala tenuifolia, Ginseng, Poria cocos, and Acorus tatarinowii. Kaixinsan has long been used as a classic formula for treating depression (Wang et al, 2022a;Jiao et al, 2022). Its antidepressant effects have been demonstrated both in vivo and in vitro by activating autophagy and suppressing NLRP3-mediated inflammation (Yu et al, 2021).…”
Section: Tcm Compoundsmentioning
confidence: 99%
“…It is composed of Polygala tenuifolia, Ginseng, Poria cocos, and Acorus tatarinowii. Kaixinsan has long been used as a classic formula for treating depression (Wang et al, 2022a;Jiao et al, 2022). Its antidepressant effects have been demonstrated both in vivo and in vitro by activating autophagy and suppressing NLRP3-mediated inflammation (Yu et al, 2021).…”
Section: Tcm Compoundsmentioning
confidence: 99%