2023
DOI: 10.1371/journal.pone.0275550
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Kynurenic acid, a key L-tryptophan-derived metabolite, protects the heart from an ischemic damage

Einat Bigelman,
Metsada Pasmanik-Chor,
Bareket Dassa
et al.

Abstract: Background Renal injury induces major changes in plasma and cardiac metabolites. Using a small- animal in vivo model, we sought to identify a key metabolite whose levels are significantly modified following an acute kidney injury (AKI) and to analyze whether this agent could offer cardiac protection once an ischemic event has occurred. Methods and results Metabolomics profiling of cardiac lysates and plasma samples derived from rats that underwent AKI 1 or 7 days earlier by 5/6 nephrectomy versus sham-operat… Show more

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Cited by 4 publications
(4 citation statements)
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“…significant role in mediating cardiac protection following acute kidney injury [26]. These findings reinforce a potential major role of KYNA in protecting the heart against ischemia/reperfusion injuries.…”
Section: Kyna Reduced In Vitro Cell Death and Prevented Mitochondrial...supporting
confidence: 61%
See 3 more Smart Citations
“…significant role in mediating cardiac protection following acute kidney injury [26]. These findings reinforce a potential major role of KYNA in protecting the heart against ischemia/reperfusion injuries.…”
Section: Kyna Reduced In Vitro Cell Death and Prevented Mitochondrial...supporting
confidence: 61%
“…Thus, we evaluated mRNA as well as protein expression of SOD1, SOD2, SOD3, and catalase. The SOD1 and catalase mRNA levels were significantly decreased following MI (28.50 ± 1.81 in the MI vs. 38.33 ± 1.95 in the sham for SOD1, p = 0.004; 17.21 ± 1.39 in MI vs. 26.08 ± 1.24 in sham for catalase, p < 0.001) whereas SOD2 and SOD3 mRNA remained unchanged. The KYNA treatment induced a significant increase in SOD2 mRNA expression (59.68 ± 2.96 in the MI + KYNA vs. 49.33 ± 4.61 in the MI, p = 0.049) and an increase, though not significant, in SOD3 mRNA levels (2.64 ± 0.18 in MI + KYNA vs. 2.24 ± 0.15 in MI, p = 0.08) (Figure 5A).…”
Section: Kyna Stimulated Antioxidant Defense Following Myocardial Isc...mentioning
confidence: 90%
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