2021
DOI: 10.1016/j.bbr.2021.113191
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Kynurenine 3-monooxygenase deficiency induces depression-like behavior via enhanced antagonism of α7 nicotinic acetylcholine receptors by kynurenic acid

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Cited by 22 publications
(7 citation statements)
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“…And some nicotinic compounds used in psychiatric disorders are thought to act by α7nAchR, and α7nAchR agonists or antagonists are also used in the treatment of depression. 45,46 A series of studies confirmed that activation of α7nAchR in microglia induces anti-inflammatory effects. 47,48 The α7nAchR on microglia plays an essential role in depression.…”
Section: Discussionmentioning
confidence: 93%
“…And some nicotinic compounds used in psychiatric disorders are thought to act by α7nAchR, and α7nAchR agonists or antagonists are also used in the treatment of depression. 45,46 A series of studies confirmed that activation of α7nAchR in microglia induces anti-inflammatory effects. 47,48 The α7nAchR on microglia plays an essential role in depression.…”
Section: Discussionmentioning
confidence: 93%
“…Vaginal cytology was not collected on the drug treatment days to minimize handling stress, yet in an effort to match estrous cycle stages within subjects, vehicle and PF-04859989 treatments were separated by 4 days in females [ 96 ]. To comprehensively define a role for KYNA in the timeline of sleep and affective symptoms, future preclinical and clinical studies will be imperative [ 91 , 97 , 98 ].…”
Section: Discussionmentioning
confidence: 99%
“…The proportion of five-year survival after surgical treatment ranges from 20-80%, depending on the stage, and is caused by sudden spread of the tumour. Diagnosis is based on the result of histopathological or cytological examination [25]. Radical surgical management due to the relatively aggressive course of the disease is limited to a small percentage of patients [26].…”
Section: Discussionmentioning
confidence: 99%
“…An important role in neural transmission has been discovered, that tryptophan is metabolized in the kynurenine metabolism pathway, which is implicated in the pathogenesis of depressive disorders. Some researchers (Mori Y et al) report that kynurenine 3-monooxygenase is a key enzyme in the metabolism of KYN to 3-hydroxy kynurenine [25]. In laboratory mice, this can cause depression, and may increase levels of kynurenic acid, a KYN metabolite formed by kynurenine aminotransferases.…”
Section: Discussionmentioning
confidence: 99%