Kyoto Congestive Heart Failure (KCHF) study: rationale and design

Abstract

AimsOver the last decade, major developments in medicine have led to significant changes in the clinical management of heart failure patients. This study was designed to evaluate the recent trends in clinical characteristics, management, and short‐term and long‐term prognosis of patients with acute decompensated heart failure (ADHF) in Japan.Methods and resultsThe Kyoto Congestive Heart Failure study is a prospective, observational, multicentre cohort study, enrolling consecutive ADHF patients from 19 participating hospitals in Japan from November 2014 to March 2016. A total of 4000 patients will be enrolled into the study and patients' anthropometric, socio‐economic, and clinical data from hospital admission to discharge will be collected. In addition, in a pre‐determined subgroup of patients (n=1500), a longitudinal follow‐up for 2 years is scheduled.ConclusionsThe Kyoto Congestive Heart Failure study will provide valuable information regarding patients with ADHF in the real‐world clinical practice of Japan and will be indispensable for future clinical and policy decision‐making with respect to heart failure.

Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure

“…The Kyoto Congestive Heart Failure (KCHF) registry is a physician-initiated, prospective, observational, multicenter cohort study that enrolled, without exclusion, consecutive patients who were hospitalized for ADHF for the first time between October 2014 and March 2016 in the 19 participating hospitals in Japan. The overall design of the KCHF study has been previously described in detail 15 . We enrolled consecutive patients with ADHF as defined by the modified Framingham criteria admitted to the participating centers, who underwent heart failure-specific treatment involving intravenous drugs within 24 hours after hospital presentation.…”

“…The study protocol was approved by the ethical committees at the Kyoto University Hospital (local identifier: E2311) and each participating hospital (Supplementary Materials). The requirement for written informed consent from each patient was waived because of the following reasons 9,15 , which were in accordance with Japanese ethical guidelines for epidemiologic research 16 : (1) we would use clinical information obtained in routine practice on the medical record without any risk to the subjects, (2) the waiver of normal consent procedures would not affect adversely the rights and welfare of the subjects, (3) the research could not be carried out effectively without the waiver, and (4) the subjects were provided with additional pertinent information and had the right to opt out of this study whenever appropriate. This study was registered with UMIN (UMIN identifier: UMIN000015238.…”

Demographics, Management, and In-Hospital Outcome of Hospitalized Acute Heart Failure Syndrome Patients in Contemporary Real Clinical Practice in Japan ― Observations From the Prospective, Multicenter Kyoto Congestive Heart Failure (KCHF) Registry ―

“…[6][7][8][9][10][11][12] In addition, the information on physical, living, and socioeconomic status derived from the present registry would be important not only for health-care providers, but also for patients, their family members, and policy-makers. 15 In the stable chronic condition, the features of HFmrEF were more similar to those of HFpEF. 22 Data on HFmrEF, however, are scarce in patients with ADHF in Japan.…”

“…The overall design of the KCHF study has been previously described in detail. 15 We enrolled all patients with ADHF as defined by the modified Framingham criteria, who were admitted to the participating centers, 16,17 and those who underwent HF-specific treatment involving i.v. drugs ≤24 h after hospital presentation.…”

“…2 In the present KCHF registry, we collected very comprehensive data in all consecutive patients hospitalized with ADHF including those with acute coronary syndrome, renal failure, anemia, or infectious diseases in multiple centers in a prospective manner. 15 Consequently, this is the first "all-comer" registry and the most up-to-date registry collecting various outcomes after the recent guidelines for HF have been available. The median age of 80 years in this registry was notably higher than that in all the previous large registries on ADHF (Table S5).…”