L -5-Hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers

Schruers, Koen; Diest, Rob van; Nicolson, Nancy A.; Griez, Eric

doi:10.1007/s00213-002-1072-8

Cited by 24 publications

(12 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In both studies cortisol was increased, in spite of the subjects reporting no change in anxiety. In the third study, 200 mg of same drug were orally administered, and salivary cortisol was assayed (Schruers et al 2002). A similar increase in cortisol was observed after 5-HTP ingestion in both PD patients and controls, testifying against the 5-HT receptor supersensitivity hypothesis of PD mentioned above.…”

Section: Serotoninergic Agentsmentioning

confidence: 56%

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

Graeff

Garcia-Leal

Del-Ben

et al. 2005

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

A bibliographic search has been performed in MEDLINE using cortisol and panic as key-words, occurring in the title and/or in the abstract. Human studies were selected, with no time limit. The following publications were excluded: review articles, case reports, panic attacks in disorders other than panic disorder, and studies on changes that occurred in-between panic attacks. The results showed that real-life panic attacks as well as those induced by selective panicogenic agents such as lactate and carbon dioxide do not activate the hypothalamicpituitary-adrenal (HPA) axis. Agonists of the colecystokinin receptor B, such as the colecystokinin-4 peptide and pentagastrin, increase stress hormones regardless of the occurrence of a panic attack and thus, seem to activate the HPA axis directly. The benzodiazepine antagonist flumazenil does not increase stress hormones, but this agent does not reliably induce panic attacks. Pharmacological agents that increased anxiety in both normal subjects and panic patients raised stress hormone levels; among them are the α 2 -adrenergic antagonist yohimbine, the serotonergic agents 1-(m-chlorophenyl) piperazine (mCPP) and fenfluramine, as well as the psychostimulant agent caffeine. Therefore, the panic attack does not seem to activate the HPA axis, in contrast to anticipatory anxiety.

show abstract

Section: Serotoninergic Agentsmentioning

confidence: 56%

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

Graeff

Garcia-Leal

Del-Ben

et al. 2005

An. Acad. Bras. Ciênc.

View full text Add to dashboard Cite

show abstract

“…After the neurological evaluation and the recording of the EEG, a dosage of 2 mg/kg per day of L -5-HTP [13,24,30] was administered at bedtime to all patients of group A for a single period of 20 consecutive days. Blood samples were monitored on a regular basis every month in order to detect the eventual occurrence of eosinophilia, with the aim of avoiding the development of eosinophilia-myalgia syndrome (EMS), previously reported during treatment with L -tryptophan [21,22].…”

Section: Protocolmentioning

confidence: 99%

l -5-Hydroxytryptophan treatment of sleep terrors in children

et al. 2004

View full text Add to dashboard Cite

show abstract

“…3 Thus, some aspect of ovarian function appears to mediate the relation between social status and 5-HT neurotransmission in females. Furthermore, since 5-HT modulates corticosteroid hormone release in response to stress, 4,5 and cortisol may effect 5-HT neurotransmission, 6 the hypercortisolemia characteristic of subordinate females may be involved in social status differences in 5-HT neurotransmission.…”

Section: Introductionmentioning

confidence: 99%

Soy and social stress affect serotonin neurotransmission in primates

Shively

Mirkes

et al. 2003

Pharmacogenomics J

View full text Add to dashboard Cite

Stress and sex steroidal milieu can each influence mood in women. The purpose of this study was to compare the effect of long-term conjugated equine estrogen (CEE), soy phytoestrogen (SPE), and social subordination stress on dorsal raphe serotonin neurotransmission of ovariectomized cynomolgus monkeys. Tryptophan hydroxylase (TPH) and serotonin reuptake transporter (SERT) protein content were determined, and the in vitro degradation of macaque SERT protein was examined in the presence and absence of protease inhibitors, serotonin (5-HT), and citalopram. Like CEE, SPE increased TPH protein levels. Social subordinates had markedly lower TPH protein levels than dominants regardless of hormone replacement. Therefore, these two variables had independent and additive effects. CEE and SPE increased SERT, and social status had no effect. Thus, the hormoneinduced increase in SERT was accompanied by increased 5-HT synthesis and neuronal firing, which appears biologically reasonable as 5-HT prevented SERT degradation in vitro.

show abstract

L -5-Hydroxytryptophan induced increase in salivary cortisol in panic disorder patients and healthy volunteers

Abstract: The results show that L-5-hydroxytryptophan stimulated salivary cortisol is a useful probe of serotonin function in healthy volunteers as well as panic disorder patients, and provide some evidence against a serotonin receptor hypersensitivity in panic disorder.

Cited by 24 publications

References 33 publications

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

Does the panic attack activate the hypothalamic-pituitary-adrenal axis?

l -5-Hydroxytryptophan treatment of sleep terrors in children

Soy and social stress affect serotonin neurotransmission in primates

Contact Info

Product

Resources

About