L-627, a novel carbapenem: in-vitro activity against anaerobes

García-Rodríguez, J A; Garcı́a-Sánchez, José Elı́as; Trujillano-Martín, I.; Garcı́a-Sánchez, Enrique; García‐García, Inés; Fresnadillo-Martinez, J.

doi:10.1093/jac/33.1.183-a

Cited by 14 publications

(13 citation statements)

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“…pneumoniae in pre-school children (,7 years), school children (7-15 years) and adults were 19.0, 6.0 and 0.8 %, respectively; isolation frequencies of H. influenzae were 13.0, 6.0 and 3.0 % and isolation frequencies of M. catarrhalis were 27.0, 4.0 and 2.0 % (Gunnarsson et al, 1998). Another study reported that colonization of these three bacteria peaked at 2-3 years of age and decreased gradually up to 15-16 years (García-Rodríguez & Fresnadillo Martínez, 2002). In contrast, the colonization patterns of Staph.…”

Section: Association Between Colonization Of the Four Bacteriamentioning

confidence: 96%

“…Recent epidemiological studies and in vivo animal studies have shown subtle but conflicting views of the associations between potential respiratory pathogens in the URT (García-Rodríguez & Fresnadillo Martínez, 2002;Murphy et al, 2009). Interbacterial competition between Strep.…”

Section: Association Between Colonization Of the Four Bacteriamentioning

confidence: 99%

“…In the human URT, bacterial colonization is a dynamic process in which bacteria are acquired, eliminated and reacquired many times during a human life and can be influenced by various factors such as host age, immune status, exposure to antibiotics, smoking and overcrowded living conditions (Marchisio et al, 2001;García-Rodríguez & Fresnadillo Martínez, 2002;Chen et al, 2007;Mukundan et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

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Nasal colonization by four potential respiratory bacteria in healthy children attending kindergarten or elementary school in Seoul, Korea

Bae

Lee

et al. 2012

Journal of Medical Microbiology

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A longitudinal analysis was carried out of the colonization by four potential respiratory pathogens -Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis and Staphylococcus aureus -in 165 healthy children (aged 3-7 years) attending three kindergartens and 417 healthy children (aged 7-10 years) attending an elementary school in Seoul, Korea, by four consecutive examinations over 1 year. The prevalence of nasal carriers of one or more of four bacteria was found to be higher in younger children (¡7 years) (mean 68.6 %) than that in older children (mean 46.8 %). The mean rates of nasal carriage of Strep. pneumoniae, H. influenzae, M. catarrhalis and Staph. aureus were 16.8, 18.9, 20.2 and 18.2 %, respectively. Colonization by Strep. pneumoniae, H. influenzae and M. catarrhalis was higher in pre-school children (28.6, 32.4 and 35.0 %, respectively) than in school children (12.2, 13.6 and 14.3 %, respectively). Carriage trends differed with age, with Strep. pneumoniae, H. influenzae and M. catarrhalis colonization decreasing with age but Staph. aureus colonization increasing. Positive associations of co-occurrence between Strep. pneumoniae, H. influenzae and M. catarrhalis were evident, with a significant negative association evident between Staph. aureus and the other three bacteria. A better understanding of the colonization and interaction of potential respiratory pathogens may be important for predicting changes in bacterial ecology and for designing control strategies that target bacterial colonization in upper respiratory tract infections.

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Section: Association Between Colonization Of the Four Bacteriamentioning

confidence: 96%

Section: Association Between Colonization Of the Four Bacteriamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Nasal colonization by four potential respiratory bacteria in healthy children attending kindergarten or elementary school in Seoul, Korea

Bae

Lee

et al. 2012

Journal of Medical Microbiology

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“…Estimación de los parámetros farmacodinámicos de CFX Los valores observados de CIM, CBM y CEBM se estimaron mediante técnicas basadas en el principio de dilución, realizadas utilizando diluciones 1:2 de soluciones de CFX, lo que presenta una imprecisión del 100%, ya que los verdaderos valores de éstos se encontrarán entre estos valores observados y las concentraciones inferiores presentes en las diluciones siguientes (García Rodríguez et al, 2001). Considerando esta limitación, Forrest et al (1997), introdujeron el concepto de CIM punto medio (MIC mid-point), que es un valor de concentración promedio entre el valor observado de la CIM y el siguiente valor menor en la serie de diluciones.…”

Section: Efecto Del Ph Sobre La Actividad Antibacteriana De Cfxunclassified

Actividad antibacteriana in vitro de Ciprofloxacina sobre una cepa autóctona de Escherichia coli: efecto del pH sobre su potencia y efecto de la persistencia bacteriana sobre su modo de acción

Patricelli¹,

Dell'elce²,

Weidmann³

et al. 2017

FAVE Cs Vet

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RESUMEN. En este trabajo se evaluó in vitro:(i) el efecto del pH sobre la actividad bactericida de ciprofloxacina (CFX) frente a una cepa autóctona de Escherichia coli y (ii) el efecto de las bacterias persistentes sobre el modo de acción concentración dependiente de CFX. La actividad antibacteriana de CFX disminuyó a causa del descenso del pH, por lo que los valores de concentración inhibitoria mínima (CIM), concentración bactericida mínima (CBM) y concentración de erradicación bacteriana mínima (CEBM) se incrementaron cuando el pH del medio de cultivo descendió de 7,4 a valores de 6,5 y 5,5. La cinética de eliminación bacteriana de CFX fue bifásica a causa de la selección de una sub-población de bacterias persistentes que presentaron una velocidad de eliminación más lenta. Por lo tanto la actividad bactericida de CFX fue definida por su concentración en relación a la CIM y el tiempo durante el cual se mantuvo la exposición de las bacterias a ésta.SUMMARY. In vitro antibacterial activity of ciprofloxacin against a native strain of Escherichia coli: effect of pH on its potency and effect of bacterial persistence on its mode of action. In this in vitro assay was evaluated: (i) the effect of pH on the bactericidal activity of ciprofloxacin (CFX) against a native strain of Escherichia coli, (ii) the effect of persister bacteria on the concentration-dependent mode of action of CFX. The antibacterial activity of CFX decreased with reductions of pH, so the values of minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and minimum eradication bacterial concentration (MEBC) were increased when the pH of the culture medium decreased from 7.4 to 6.5 and 5.5. The kinetics of bacterial elimination of CFX presented a biphasic pattern because of the selection of a sub-population of persistent bacteria which presented a slower elimination rate. Therefore, the antibacterial activity of CFX was determined by its concentration in reference to MIC values and the time during which the exposure of the bacteria was maintained.Palabras clave: Escherichia coli, eficacia, modo de acción, pH, bacterias persistentes.

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“…Its in vitro activity against anaerobes was the subject of a number of studies in the 1990s, around the time of its development (1,(4)(5)(6)(7)(8)(9)(10). Biapenem was approved for clinical use in Japan in 2001 and was launched in 2002.…”

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confidence: 99%

In VitroActivity of Biapenem plus RPX7009, a Carbapenem Combined with a Serine β-Lactamase Inhibitor, against Anaerobic Bacteria

Goldstein

Citron²,

Tyrrell³

et al. 2013

Antimicrob Agents Chemother

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bBiapenem is a carbapenem being developed in combination with RPX7009, a new inhibitor of serine ␤-lactamases. Biapenem was tested alone and in combination with fixed concentrations of RPX7009 by agar dilution against 377 recent isolates of anaerobes. A separate panel of 27 isolates of Bacteroides spp. with decreased susceptibility or resistance to imipenem was also tested. Comparator drugs included meropenem, piperacillin-tazobactam, ampicillin-sulbactam, cefoxitin, ceftazidime, metronidazole, clindamycin, and tigecycline plus imipenem, doripenem, and ertapenem for the 27 selected strains. For recent consecutive strains of Bacteroides species, the MIC 90 for biapenem-RPX7009 was 1 g/ml, with a MIC 90 of 4 g/ml for meropenem. Other Bacteroides fragilis group species showed a MIC 90 of 0.5 g/ml for both agents. The MIC 90 s for biapenem-RPX7009 were 0.25 g/ml for Prevotella spp., 0.125 g/ml for Fusobacterium nucleatum and Fusobacterium necrophorum, 2 g/ml for Fusobacterium mortiferum, 0.5 g/ml for Fusobacterium varium, <0.5 g/ml for Gram-positive cocci and rods, and 0.03 to 8 g/ml for clostridia. Against 5 B. fragilis strains harboring a known metallo-beta-lactamase, biapenem-RPX7009 MICs were comparable to those of other carbapenems (>32 g/ml). Against Bacteroides strains with an imipenem MIC of 2 g/ml, biapenem-RPX7009 had MICs of 0.5 to 2 g/ml, with MICs of 0.5 to 32 g/ml for meropenem, doripenem, and ertapenem. For strains with an imipenem MIC of 4 g/ml, the MICs for biapenem-RPX7009 were 4 to 16 g/ml, with MICs of 8 to >32 g/ml for meropenem, doripenem, and ertapenem. The inhibitor RPX7009 had no antimicrobial activity when tested alone, and it showed little or no potentiation of biapenem versus anaerobes. Biapenem-RPX7009 showed activity comparable to that of imipenem and was superior to meropenem, doripenem, and ertapenem against imipenem-nonsusceptible Bacteroides spp.

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L-627, a novel carbapenem: in-vitro activity against anaerobes

Cited by 14 publications

References 0 publications

Nasal colonization by four potential respiratory bacteria in healthy children attending kindergarten or elementary school in Seoul, Korea

Nasal colonization by four potential respiratory bacteria in healthy children attending kindergarten or elementary school in Seoul, Korea

Actividad antibacteriana in vitro de Ciprofloxacina sobre una cepa autóctona de Escherichia coli: efecto del pH sobre su potencia y efecto de la persistencia bacteriana sobre su modo de acción

In VitroActivity of Biapenem plus RPX7009, a Carbapenem Combined with a Serine β-Lactamase Inhibitor, against Anaerobic Bacteria

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