L'action centrale des antagonistes calciques

Bentué-Ferrer, Danièle; Decombe, R.; Reymann, Jean-Michel; Allain, H.

doi:10.1016/s0248-8663(89)80100-6

Cited by 2 publications

(3 citation statements)

References 46 publications

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“…Nevertheless, the effects of antihypertensive treatments on cognitive function are still a matter of debate. In the literature, few double‐blind placebo controlled studies have been devoted to the analysis of central nervous system (CNS) effects induced by antihypertensive agents [6–8]. The Syst‐Eur Vascular Dementia Trial recently showed that antihypertensive drug treatment could reduce the incidence of dementia by 50%: treatment of 1000 elderly patients with isolated systolic hypertension with a calcium‐channel blocker, nitrendipine, in first‐line medication for 5 years was estimated to have prevented 19 cases of dementia in addition to 53 major cardiovascular events [9].…”

Section: Introductionmentioning

confidence: 99%

Effects of nicardipine and clonidine on cognitive functions and electroencephalography in hypertensive patients

Denolle¹,

Sassano

Allain

et al. 2002

Fundamemntal Clinical Pharma

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The aim of this study was to investigate the cognitive and electroencephalography (EEG) short-term effects of a calcium antagonist, nicardipine, compared to placebo and clonidine (which, having known sedative effects, acted as a negative control) for 15 days in elderly hypertensive patients with memory complaints. Nicardipine and clonidine were compared with placebo in a double-blind, randomized, three-way cross-over controlled study after a 2-week placebo run-in period. This was a phase II clinical study carried out on out-patients in a single research centre. Fifteen elderly (63 +/- 10 years) hypertensive patients, without dementia but with memory complaints, were included. Psychomotor performance and cognition were assessed using both an extensive battery of validated psychometric tests (which evaluated attention and vigilance, body sway and memory) and an EEG profile. Cardiovascular parameters measured were blood pressure and heart rate. No detrimental effects of nicardipine were found on attention, vigilance, body sway or memory. Nicardipine produced a significant increase in alpha EEG energies, which may indicate possible alerting effects. In contrast, clonidine induced well-known deleterious sedative effects in psychometric tests and in EEG analysis (decrease in alpha and increase in delta and theta waves). The two drugs produced equivalent decreases in blood pressure at steady state. In conclusion, clonidine induced well-known sedative effects, while nicardipine did not impair central nervous system activity and may have had some short-term alerting effects in elderly hypertensive patients with memory complaints. This study supports the hypothesis of a dissociation between blood pressure and direct drug effects on the central nervous system.

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Section: Introductionmentioning

confidence: 99%

Effects of nicardipine and clonidine on cognitive functions and electroencephalography in hypertensive patients

Denolle¹,

Sassano

Allain

et al. 2002

Fundamemntal Clinical Pharma

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“…After years of solely cardiovascular use of these compounds, the pharmacology of CA now encompasses many other tissues, including the central nervous system (CNS). , 1986; BentuC-Ferrer et al, 1989;Raeburn & Gonzales, 1988). , 1986; BentuC-Ferrer et al, 1989;Raeburn & Gonzales, 1988).…”

Section: Introductionmentioning

confidence: 99%

“…An increasing number of studies on the use of CA in neuropsychiatric conditions are being reported, although many of these results are yet to be confirmed (Takahashi & Ogura, 1983 ;Govoni et al, 1985 ; Spedding & Middlemiss, 1985, Fieschi et al, 1986; Godfraind et a/. , 1986; BentuC-Ferrer et al, 1989;Raeburn & Gonzales, 1988). Most of these studies focussed on the cerebrosvascular effects of these drugs with regard to migraine, cerebrovascular spasm and ischaemia.…”

Section: Introductionmentioning

confidence: 99%

Clinical Neuropharmacology of Calcium Antagonists

Delumeau

Bentué-Ferrer²,

Saiag

et al. 1989

Fundamemntal Clinical Pharma

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Experimental and clinical data clearly demonstrate that calcium antagonists (CA) may have an action on the central nervous system (CNS). The cerebrovascular action of CA justifies their use in cerebral ischaemia, vasospasm and hypoxia. Several clinical trials have demonstrated such beneficial effects. On the other hand a number of reports indicate that CA may have a direct neuronal effect, although most of such trials have not been verified or are mere case reports. In addition, the large number of conditions susceptible to being corrected by CA is impressive: epilepsy, pain, dystonia, dyskinesia, psychiatric conditions, etc. Other papers are disconcerting that report extrapyramidal disorders induced by flunarizine and cinnarizine in the elderly, whereas nicardipine does not produce such side effects and may even alleviate some parkinsonian symptoms. In various experimental models (e.g. stroke, oedema), pharmacological effects have been shown to vary from one compound to the other. Two main questions are yet to be answered: 1) has the direct neuronal effect of CA been clearly established? 2) are the multiple clinical effects on the CNS really linked to calcium antagonism?

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L'action centrale des antagonistes calciques

Cited by 2 publications

References 46 publications

Effects of nicardipine and clonidine on cognitive functions and electroencephalography in hypertensive patients

Effects of nicardipine and clonidine on cognitive functions and electroencephalography in hypertensive patients

Clinical Neuropharmacology of Calcium Antagonists

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