L’angiogenèse tumorale

Treps, Lucas; Gavard, Julie

doi:10.1051/medsci/20153111013

Cited by 8 publications

(5 citation statements)

References 30 publications

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“…The endothelial junctions of tumor vessels are also aberrant and less cohesive: the glioblastoma secretome provides pro-angiogenic and inflammatory signals (here CXCL8), disrupts the junctions formed by VE-cadherin and promotes the permeability of brain endothelial cells [56]. Thus, abnormalities in the structure and composition of tumor vessels combined with a microenvironment rich in pro-angiogenic and inflammatory factors, are responsible for the abnormally high vascular permeability of tumors [57]. These vascular abnormalities create a hostile environment characterized by hypoxia, low pH, inflammation, and high interstitial pressure that select the most aggressive cancer cells.…”

Section: Tumor Neovascularizationmentioning

confidence: 99%

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

Penco-Campillo

Pagès

Martial

2023

Biology

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Medulloblastoma (MB) is the most prevalent brain tumor in children. Although the current cure rate stands at approximately 70%, the existing treatments that involve a combination of radio- and chemotherapy are highly detrimental to the patients’ quality of life. These aggressive therapies often result in a significant reduction in the overall well-being of the patients. Moreover, the most aggressive forms of MB frequently relapse, leading to a fatal outcome in a majority of cases. However, MB is highly vascularized, and both angiogenesis and lymphangiogenesis are believed to play crucial roles in tumor development and spread. In this context, our objective is to provide a comprehensive overview of the current research progress in elucidating the functions of these two pathways.

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Section: Tumor Neovascularizationmentioning

confidence: 99%

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

Penco-Campillo

Pagès

Martial

2023

Biology

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“…116 High permeability in new vasculature structures promotes the direct entry of tumor cells into the circulation. 133 Moreover, the irregular and unstable structure of these neovascular systems lead to a dense vascular bed that increases contact surfaces between tumors and the bloodstream, promoting tumor access to the circulation and facilitating distant metastasis. 133 Therefore, angiogenesis is instrumental in primary tumor metastasis and growth.…”

Section: Lncrnas Involved In Angiogenesismentioning

confidence: 99%

Revisiting Lung Cancer Metastasis: Insight From the Functions of Long Non-coding RNAs

Huang

Zhu

Liang

et al. 2021

Technol Cancer Res Treat

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Globally, lung cancer is the most common cause of cancer-related deaths. After diagnosis at all stages, <7% of patients survive for 10 years. Thus, diagnosis at later stages and the lack of effective and personalized drugs reflect a significant need to better understand the mechanisms underpinning lung cancer progression. Metastasis should be responsible for the high lethality and recurrence rates seen in lung cancer. Metastasis depends on multiple crucial steps, including epithelial–mesenchymal transition, vascular remodeling, and colonization. Therefore, in-depth investigations of metastatic molecular mechanisms can provide valuable insights for lung cancer treatment. Recently, long noncoding RNAs (lncRNAs) have attracted considerable attention owing to their complex roles in cancer progression. In lung cancer, multiple lncRNAs have been reported to regulate metastasis. In this review, we highlight the major molecular mechanisms underlying lncRNA-mediated regulation of lung cancer metastasis, including (1) lncRNAs acting as competing endogenous RNAs, (2) lncRNAs regulating the transduction of several signal pathways, and (3) lncRNA coordination with enhancer of zeste homolog 2. Thus, lncRNAs appear to execute their functions on lung cancer metastasis by regulating angiogenesis, autophagy, aerobic glycolysis, and immune escape. However, more comprehensive studies are required to characterize these lncRNA regulatory networks in lung cancer metastasis, which can provide promising and innovative novel therapeutic strategies to combat this disease.

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“…Unlike physiological angiogenesis, cancer angiogenesis is an inefficient process with sub-optimal perfusion, lack of vessel integrity and disorganized vessel network [ 39 ]. However, the newly-formed premature vessels provide the growing tumor tissue with adequate metabolites [ 40 ].…”

Section: Cancer Angiogenesismentioning

confidence: 99%

MicroRNAs in cancer metastasis and angiogenesis

Liu²,

et al. 2017

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Cancer metastasis is a malignant process by which tumor cells migrate from their primary site of origin to other organs. It is the main cause of poor prognosis in cancer patients. Angiogenesis is the process of generating new blood capillaries from pre-existing vasculature. It plays a vital role in primary tumor growth and distant metastasis. MicroRNAs are small non-coding RNAs involved in regulating normal physiological processes as well as cancer pathogenesis. They suppress gene expression by specifically binding to the 3′-untranslated region (3′-UTR) of their target genes. They can thus act as oncogenes or tumor suppressors depending on the function of their target genes. MicroRNAs have shown great promise for use in anti-metastatic cancer therapy. In this article, we review the roles of various miRNAs in cancer angiogenesis and metastasis and highlight their potential for use in future therapies against metastatic cancer.

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L’angiogenèse tumorale

Cited by 8 publications

References 30 publications

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

Angiogenesis and Lymphangiogenesis in Medulloblastoma Development

Revisiting Lung Cancer Metastasis: Insight From the Functions of Long Non-coding RNAs

MicroRNAs in cancer metastasis and angiogenesis

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