L'antigène carbohydrate CA125: propriétés biochimiques et moléculaires

Bouanene, Houda; Miled, Abdelhédi

doi:10.1684/bdc.2009.0859

Cited by 4 publications

(2 citation statements)

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“…High serum CA 125 levels have been identified in malignancies such as ovarian, lung and gastrointestinal cancer ( 4 ). Currently, CA 125 is a widely used biomarker for the screening ( 5 ), monitoring ( 6 ) and risk stratification ( 7 ) of ovarian cancer. In addition, emerging evidence has linked serum CA 125 levels to non-malignant conditions such as cardiovascular disease (e.g., heart failure, pericardial diseases, and coronary artery disease) ( 8 ).…”

Section: Introductionmentioning

confidence: 99%

Carbohydrate Antigen 125 Is a Biomarker of the Severity and Prognosis of Pulmonary Hypertension

Zhang

Jin

Zhao

et al. 2021

Front. Cardiovasc. Med.

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Background: Emerging evidence has showed that serum carbohydrate antigen 125 (CA 125) levels are associated with the severity and prognosis of heart failure. However, its role in pulmonary hypertension remains unclear. This study aimed to investigate the clinical, echocardiographic, hemodynamic, and prognostic associations of CA 125 in pulmonary hypertension.Methods and Results: We conducted a retrospective cohort study of all idiopathic pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertension patients receiving CA 125 measurement in Fuwai Hospital (January 1, 2014–December 31, 2018). The primary end-point was cumulative 1-year clinical worsening-free survival rate. Linear regression was performed to assess the association between CA 125 and clinical, echocardiographic, and hemodynamic parameters. Cox proportional hazards models were used to assess the association between CA 125 and clinical worsening events. Receiver operating characteristic (ROC) curve analysis was performed to determine the predictive performance of CA 125. A total of 231 patients were included. After adjustment, CA 125 still positively correlated with World Health Organization functional class, NT-proBNP, right ventricular end-diastolic diameter, pericardial effusion, mean right atrial pressure and pulmonary arterial wedge pressure; negatively correlated with 6-min walk distance, left ventricular end-diastolic diameter, mixed venous oxygen saturation, and cardiac index. After adjustment, CA 125 > 35 U/ml was associated with over 2 folds increased risk of 1-year clinical worsening. Further, ROC analysis showed that CA 125 provided additional predictive value in addition to the established pulmonary hypertension biomarker NT-proBNP.Conclusion: CA 125 was associated with functional status, echocardiography, hemodynamics and prognosis of pulmonary hypertension.

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Section: Introductionmentioning

confidence: 99%

Carbohydrate Antigen 125 Is a Biomarker of the Severity and Prognosis of Pulmonary Hypertension

Zhang

Jin

Zhao

et al. 2021

Front. Cardiovasc. Med.

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“…Studies reveal that CA125 originates from the cell surfaces of various tissues of the coelomic epithelium. Additionally, it's expressed by the mesothelial cells of the peritoneum and all other Mullerian tissues, including the tubal endothelium, the endocervix, and others.Therefore, CA 125 is mainly associated with epithelial tumours, in particular epithelial ovarian cancer (6).…”

Section: Reminder On Ca 125mentioning

confidence: 99%

Verification of the analytical performance of the serum CA 125 assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda

Nisma Douzi,

Amina Himri,

Imad-Eddine El khamlichi

et al. 2024

GSC Biol. Pharm. Sci.

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The aim of our work was to evaluate the analytical performance of CA 125 determination by a two-step immunoassay using microparticle chemiluminescence immunoassay (CMIA) technology, in accordance with the Scope A criteria of the guide of the verification/validation of medical biology methods. We evaluated the repeatability and the intermediate precision of the CA 125 assay.The results obtained are very satisfactory for the three levels (low, medium and high), both for intermediate fidelity, with coefficients of variation (CV) of 2.68%, 1.62% and 2.11% respectively, and for repeatability, with coefficients of variation of CV1 = 2.17%, CV2 = 2.04%, and CV3 = 1.38% respectively. The results obtained made it possible to verify the method's performance and compare it with the analytical objectives set in order to meet the regulatory and normative requirements set by the supplier and learned societies. The achieved results facilitated the verification of the method's performance and its comparison with the analytical objectives established, aligning with regulatory and normative requirements outlined by the supplier and relevant professional learned societies.

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Extracellular Vesicles Contain Putative Cancer Biomarkers

Chitti

Nedeva

2021

Subcellular Biochemistry

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L'antigène carbohydrate CA125: propriétés biochimiques et moléculaires

Cited by 4 publications

References 0 publications

Carbohydrate Antigen 125 Is a Biomarker of the Severity and Prognosis of Pulmonary Hypertension

Carbohydrate Antigen 125 Is a Biomarker of the Severity and Prognosis of Pulmonary Hypertension

Verification of the analytical performance of the serum CA 125 assay on the Abbott Alinity ci®: Experience of the biochemistry laboratory of the Mohammed VI university hospital of Oujda

Extracellular Vesicles Contain Putative Cancer Biomarkers

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