L-arginine Attenuates Hypobaric Hypoxia-Induced Increase in Ornithine Decarboxylase 1

Li, Yuhong; Zhengzhong, Bai; Tian, Feng; Yang, Qingcheng; Ge, Ri‐Li

doi:10.1016/j.wem.2017.05.009

Cited by 4 publications

(2 citation statements)

References 19 publications

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“…bulgaricus. The existing research also confirms that injecting arginine can reduce patients' AMS scores [51] and alleviate mean pulmonary artery pressure in rat lung tissue caused by acute hypobaric hypoxia [52]. It is necessary to precisely detect the levels of arginine and tyrosine in mouse feces through targeted metabolomic approaches next, to explore their relationship with acute hypoxic injury in mice.…”

Section: Discussionmentioning

confidence: 87%

Lactobacillus delbrueckii subsp. bulgaricus Alleviates Acute Injury in Hypoxic Mice

Song,

Ling,

Wang

et al. 2024

Nutrients

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Acute mountain sickness (AMS) is a common ailment in high-altitude areas caused by the body’s inadequate adaptation to low-pressure, low-oxygen environments, leading to organ edema, oxidative stress, and impaired intestinal barrier function. The gastrointestinal tract, being the first to be affected by ischemia and hypoxia, is highly susceptible to injury. This study investigates the role of Lactobacillus delbrueckii subsp. bulgaricus in alleviating acute hypoxic-induced intestinal and tissue damage from the perspective of daily consumed lactic acid bacteria. An acute hypoxia mouse model was established to evaluate tissue injury, oxidative stress, inflammatory responses, and intestinal barrier function in various groups of mice. The results indicate that strain 4L3 significantly mitigated brain and lung edema caused by hypoxia, improved colonic tissue damage, and effectively increased the content of tight junction proteins in the ileum, reducing ileal permeability and alleviating mechanical barrier damage in the intestines due to acute hypoxia. Additionally, 4L3 helped to rebalance the intestinal microbiota. In summary, this study found that Lactobacillus delbrueckii subsp. bulgaricus strain 4L3 could alleviate acute intestinal damage caused by hypoxia, thereby reducing hypoxic stress. This suggests that probiotic lactic acid bacteria that exert beneficial effects in the intestines may alleviate acute injury under hypoxic conditions in mice, offering new insights for the prevention and treatment of AMS.

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Section: Discussionmentioning

confidence: 87%

Lactobacillus delbrueckii subsp. bulgaricus Alleviates Acute Injury in Hypoxic Mice

Song,

Ling,

Wang

et al. 2024

Nutrients

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“…In this study, the HT group of greater amberjack was found to produce a significant downregulation of the odc1 gene relative to the HS group when exposed to hypoxic stress, resulting in the inhibition of antioxidant activity. ODC1 (ornithine decarboxylase1), encoded by odc1, is the rate-limiting enzyme for the synthesis of polyamines [45], which play a key role in cell proliferation, differentiation, and antioxidation [46]. Furthermore, the expression of odc1 was significantly correlated with the antioxidant activity of GSH (glutathione).…”

Section: Antioxidant Effect and Apoptosismentioning

confidence: 99%

Liver Transcriptome Shows Differences between Acute Hypoxia-Tolerant and Intolerant Individuals of Greater Amberjack (Seriola dumerili)

Li,

Yang,

Wang

et al. 2023

Animals

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Acute hypoxia is a common abiotic stress in commercial aquaculture and has significant effects on fish physiology and metabolism. Due to its large size and rapid growth, the greater amberjack (Seriola dumerili) is an economically important fish with high farming value. This species is intolerant to hypoxia, which makes it susceptible to mass mortality and hinders the progress of amberjack cultivation. Based on a comparative analysis of the liver transcriptome between acute hypoxia-tolerant (HT) and -intolerant (HS) groups, this study first explored the molecular mechanisms of acute hypoxia in greater amberjack. By simulating the acute hypoxic environment and using RNA sequencing (RNA-Seq), the differences in liver transcriptional changes between the acute hypoxia-tolerant (HT) and hypoxia-intolerant (HS) groups of greater amberjack were probed. Based on differential expression analysis, 829 differentially expressed genes (DEGs) were screened in both groups. Relative to the HS group, 374 DEGs were upregulated and 455 were downregulated in the HT group. Compared with the HS group, genes such as slc2a5 and prkaa2 related to promoting sugar transport and inhibiting lipid syntheses were upregulated, while genes that inhibit gluconeogenesis and promote lipid syntheses, such as pgp and aacs, were downregulated. The expression of odc1 was significantly and relatively downregulated in the HT group, which would lead to the inhibition of intracellular antioxidant activity and decreased scavenging of ROS. The NF-kB pathway was also promoted to some extent in individuals in the HT group relative to the HS group to resist apoptosis. In addition, the relative downregulation of apoptosis and autophagy-related genes, such as endog, hm13, and casp6, was also detected in the HT group. The present findings first reported the regulation mechanism by which liver tissue coped with the acute hypoxia stress in greater amberjack, which will provide important technical support for preventing acute hypoxia-induced death in advance and reducing economic losses.

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Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p

et al. 2023

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L-arginine Attenuates Hypobaric Hypoxia-Induced Increase in Ornithine Decarboxylase 1

Abstract: L-arginine attenuates acute hypobaric hypoxia-induced increase in mean pulmonary artery pressure and ODC1 gene expression in lung tissues of rats. ODC1 gene contributes to the development of hypoxic pulmonary hypertension.

Cited by 4 publications

References 19 publications

Lactobacillus delbrueckii subsp. bulgaricus Alleviates Acute Injury in Hypoxic Mice

Lactobacillus delbrueckii subsp. bulgaricus Alleviates Acute Injury in Hypoxic Mice

Liver Transcriptome Shows Differences between Acute Hypoxia-Tolerant and Intolerant Individuals of Greater Amberjack (Seriola dumerili)

Arginine attenuates chronic mountain sickness in rats via microRNA-144-5p

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