L-carnitine and its functional effects in poultry nutrition

Adabi, Sh. Golzar; Cooper, Ronald A.; Ceylan, Necmettin; Corduk, M.

doi:10.1017/s0043933911000304

Cited by 46 publications

(32 citation statements)

References 127 publications

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“…The molecular mechanisms accounting for the powerful antioxidant effect of LC are not yet fully understood, it could be concluded that the antioxidant action of LC is related in several ways, including scavenging free radicals, inhibiting ROS generation and boosting the function of the antioxidant system via activation of Nrf2 (Golzar Adabi et al, ; Safari et al, ; Wang et al, ). Gülçin () confirmed that LC could directly scavenge 1,1‐diphenyl‐2‐picryl‐hydrazyl free radical (DPPH·), superoxide anion radical (O 2 ·), and H 2 O 2 , as well as inhibit the ROS generation by chelate ferrous ions in vitro.…”

Section: Discussionmentioning

confidence: 99%

Effect of dietaryl‐carnitine on growth performance and antioxidant response in Amur minnow (Phoxinus lagowskiiDybowskii)

et al. 2019

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l‐carnitine (LC) is required for transporting long‐chain fatty acids into the mitochondria, where β‐oxidation takes place, and it works as an antioxidant molecule against reactive oxygen species. This study evaluated the effects of LC on the growth and antioxidant function of Amur minnow (Phoxinus lagowskii Dybowskii). Five isonitrogenous (380.4 g/kg) and isoenergetic (17.63 MJ/kg) diets were supplemented with five LC levels: control level (0 mg/kg) and treatment levels (50, 400, 750, or 1,100 mg/kg) were fed to fish (18.19 ± 0.56 g) for 120 days. The results showed that the growth performance of fish fed a diet containing 400 mg/kg of LC was significantly higher than that of the control and those fed other LC level treatments. Similarly, the 400 mg/kg treatment had the best feed efficiency. Further, the levels of total antioxidant capacity and total glutathione in the serum and hepatopancreas of fish fed a diet containing 750 mg/kg of LC were significantly increased; however, malondialdehyde levels were significantly reduced compared to those of the control group. The activities of antioxidant enzymes of 750 mg/kg treatments in the serum and hepatopancreas were significantly higher than those of the control group, including total superoxide dismutase, catalase, glutathione peroxidase and gamma‐glutamyl‐cysteine synthetase. Finally, 750 mg/kg treatment significantly upregulated the mRNA relative expression of antioxidant enzymes and nuclear factor erythroid‐2‐related factor 2 and inhibited the mRNA level of kelch‐like ECH‐associated protein 1 in the hepatopancreas. In conclusion, the dietary LC level of 400–750 mg/kg could improve the growth performance, feed utilization and antioxidant defense system of Amur minnow under the culture conditions.

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Section: Discussionmentioning

confidence: 99%

Effect of dietaryl‐carnitine on growth performance and antioxidant response in Amur minnow (Phoxinus lagowskiiDybowskii)

et al. 2019

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“…Golzar Adabi et al (2011) concluded that inclusion levels between 50 and 200 mg L-carnitine/kg feed could be added to the diets of broilers and laying hens with positive results on growth performance. No literature is available on the effect of the inclusion of dietary L-carnitine during the pre-starter period on growth performance of ostrich chicks.…”

mentioning

confidence: 99%

“…There are many conflicting reports on the response of different avian species to supplementary dietary L-carnitine (Golzar Adabi et al, 2011). These inconsistencies between studies could be related to differences in levels of L-carnitine supplementation, L-carnitine level of basal diet, nutritional and physiological status of the animal and the nutrient composition of their diets (such as dietary lipid and protein intake, supply or absence of essential amino acids).…”

mentioning

confidence: 99%

“…These inconsistencies between studies could be related to differences in levels of L-carnitine supplementation, L-carnitine level of basal diet, nutritional and physiological status of the animal and the nutrient composition of their diets (such as dietary lipid and protein intake, supply or absence of essential amino acids). Additional factors are the possible effects of enzymatic breakdown of branched-chain amino acids, sparing effects of L-carnitine and its considerable precursors (lysine and methionine), interspecies differences, differences in ingredients and metabolisable energy levels, age, sex, feeding programme and managerial or environmental conditions of animals (Sarica et al, 2007;Golzar Adabi et al, 2011). There are hypotheses regarding the actions of L-carnitine in the improvement of the growth performance that could be epitomized.…”

mentioning

confidence: 99%

“…Growth improvements due to addition of L-carnitine may be partly associated with its amino acid-sparing role in addition to its function in fatty acid metabolism. Functionally, an exogenous supplementation of L-carnitine could reduce the need for biosynthesis of L-carnitine from methionine, thus sparing methionine for other biological activities (Golzar Adabi et al, 2011).…”

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confidence: 99%

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Short communication: Responses of Black Neck ostrich chicks to L-carnitine dietary supplementation during the pre-starter growth period

Hajibabaei¹,

Casey²

2012

SA J. An. Sci.

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________________________________________________________________________________ AbstractThe objective was to determine the growth responses of Black Neck ostrich chicks to different dietary levels of L-carnitine in pre-starter diets. Thirty-two day-old ostrich chicks were randomly divided into four treatments with four replicates, each containing two chicks. All birds received the same basal diet supplemented with 0 (T0, control), 125 (T125), 250 (T250) or 600 (T600) mg L-carnitine per kg. Responses were monitored over three growth phases, 0 -15, 16 -30 and 31 -60 days, the total period being 60 days. T600 had the lowest live weight (LW) and live weight gain (LWG) over the 60-day treatment period. Live weight and LWG values of T125 and T250 did not differ from those of T0. T600 had the worst feed conversion ratio (FCR) during the different stages (0 -15, 16 -30 and 31 -60 days) and over the total 60-day period. Feed intake (FI) was reduced significantly in the T125 and T600 treatments compared to T0 and T250 treatments over the total period. The treatment, T125, showed the lowest FI and FCR responses over the total period, whereas there was no difference between T0 and T250. The results suggest that supplementing the pre-starter diet with 125 mg/kg of L-carnitine can improve the performance of ostrich chicks by decreasing the FCR. In contrast, the suppressive effect of a high inclusion level (T600) might indicate that ostrich chicks are sensitive to a high level of inclusion that could cause adverse effects. ________________________________________________________________________________

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A review of antioxidant strategies to improve reproduction in aging male broiler breeders

Barbarestani,

Samadi,

Zaghari

et al. 2024

GeroScience

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L-carnitine and its functional effects in poultry nutrition

Cited by 46 publications

References 127 publications

Effect of dietaryl‐carnitine on growth performance and antioxidant response in Amur minnow (Phoxinus lagowskiiDybowskii)

Effect of dietaryl‐carnitine on growth performance and antioxidant response in Amur minnow (Phoxinus lagowskiiDybowskii)

Short communication: Responses of Black Neck ostrich chicks to L-carnitine dietary supplementation during the pre-starter growth period

A review of antioxidant strategies to improve reproduction in aging male broiler breeders

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