L-carnitine attenuated hyperuricemia-associated left ventricular remodeling through ameliorating cardiomyocytic lipid deposition

Yang, Yang; Lin, Cuiting; Zheng, Qiang; Zhang, Leqi; Li, Yongmei; Huang, Qinghua; Wu, Ting; Zhao, Zean; Li, Lü; Luo, Jian; Jiang, Yanqing; Zhang, Qun; Wang, Xing; Xia, Chenglai; Pang, Jianxin

doi:10.3389/fphar.2023.1016633

Cited by 3 publications

(2 citation statements)

References 71 publications

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“…In the present study, we found that HUA was signi cantly and positively associated with low eGFR in elderly patients with AF, which is consistent with the ndings previous reports [35] . Although HUA has been reported to cause LV enlargement in mouse animal experiments [37] , to the best of our knowledge, this study is the rst to show that HUA is signi cantly and positively correlated with LV size in elderly patients with AF.…”

Section: Discussionmentioning

confidence: 55%

“…In HUA patients, urate crystals are easily formed due to the increase in UA concentration, these crystals are deposited in the tissue cells of the heart, kidney, blood vessels, and other organs. Urate crystals can cause an in ammatory oxidative reaction and lead to cellular lip toxicity, causing apoptosis and necrosis of glomerular epithelial cells, cardiomyocytes, and other cells, leading to a decrease in the eGFR and cardiac remodeling [36,37] . Cardiac remodeling is further aggravated by increased circulating blood volume and cardiac preloading due to renal dysfunction [38] .…”

Section: Discussionmentioning

confidence: 99%

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Correlation between hyperuricemia and cardiac remodeling in elderly patients with atrial fibrillation

Chen,

Li,

et al. 2023

Preprint

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BACKGROUND Studies have confirmed that patients with atrial fibrillation (AF) have a significantly increased risk of cardiovascular death, due to cardiac remodeling. Hyperuricemia (HUA) is also significantly associated with an increased risk of cardiovascular death. However, the correlation between HUA and cardiac remodeling in elderly patients with AF is still unclear; therefore, this study investigated the correlation between HUA and cardiac remodeling in elderly patients with AF. METHODS A total of 1153 hospitalized elderly patients with AF were retrospectively collected, and Serum uric acid (SUA) and echocardiography were measured to investigate the correlation between HUA and clinical indexes and cardiac remodeling in elderly patients with AF. RESULTS In elderly patients with AF, HUA was significantly associated with female sex, larger body mass index (BMI), lower estimated glomerular filtration rate (eGFR), and larger left ventricle (P < 0.05). CONCLUSION In elderly patients with AF, HUA was significantly associated with female sex, larger BMI, lower eGFR, and larger left ventricle.

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Correlation between hyperuricemia and cardiac remodeling in elderly patients with atrial fibrillation

Chen,

Li,

et al. 2023

Preprint

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The Role of Hyperuricemia in Cardiac Diseases: Evidence, Controversies, and Therapeutic Strategies

Zheng,

Chen,

Yang

et al. 2024

Biomolecules

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dial infarction, arrhythmias, and heart failure. We also combined recent findings from basic research to analyze potential mechanisms linking HUA with myocardial injury. In different pathological models (such as direct action of high uric acid on myocardial cells or combined with myocardial ischemia-reperfusion model), HUA may cause damage by activating the NOD-like receptor protein 3 inflammasome-induced inflammatory response, interfering with cardiac cell energy metabolism, affecting antioxidant defense systems, and stimulating reactive oxygen species production to enhance the oxidative stress response, ultimately resulting in decreased cardiac function. Additionally, we discuss the impact of lowering uric acid intervention therapy and potential safety issues that may arise. However, as the mechanism underlying HUA-induced myocardial injury is poorly defined, further research is warranted to aid in the development novel therapeutic strategies for HUA-related cardiovascular diseases.

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A combination of red and processed meat intake and polygenic risk score influences the incidence of hyperuricemia in middle-aged Korean adults

Lee,

Shin

2024

Nutr Res Pract

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BACKGROUND/OBJECTIVES The high consumption of purine-rich meat is associated with hyperuricemia. However, there is limited evidence linking the consumption of red and processed meat to the genetic risk of hyperuricemia. We investigated the relationship between various combinations of red and processed meat consumption and the polygenic risk scores (PRSs) and the incidence of hyperuricemia in middle-aged Koreans. SUBJECTS/METHODS We analyzed the data from 44,053 participants aged ≥40 years sourced from the Health Examinees (HEXA) cohort of the Korean Genome and Epidemiology Study (KoGES). Information regarding red and processed meat intake was obtained using a semiquantitative food frequency questionnaire (SQ-FFQ). We identified 69 independent single-nucleotide polymorphisms (SNPs) at uric acid-related loci using genome-wide association studies (GWASs) and clumping analyses. The individual PRS, which is the weighted sum of the effect size of each allele at the SNP, was calculated. We used multivariable Cox proportional hazards models adjusted for covariates to determine the relationship between red and processed meat intake and the PRS in the incidence of hyperuricemia. RESULTS During an average follow-up period of 5 years, 2,556 patients with hyperuricemia were identified. For both men and women, the group with the highest red and processed meat intake and the highest PRS was positively associated with the development of hyperuricemia when compared with the group with the lowest red and processed meat intake and the lowest PRS (hazard ratio [HR], 2.72; 95% confidence interval [CI], 2.10–3.53; P < 0.0001; HR, 3.28; 95% CI, 2.45–4.40; P < 0.0001). CONCLUSION Individuals at a high genetic risk for uric acid levels should moderate their consumption of red and processed meat to prevent hyperuricemia.

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L-carnitine attenuated hyperuricemia-associated left ventricular remodeling through ameliorating cardiomyocytic lipid deposition

Cited by 3 publications

References 71 publications

Correlation between hyperuricemia and cardiac remodeling in elderly patients with atrial fibrillation

Correlation between hyperuricemia and cardiac remodeling in elderly patients with atrial fibrillation

The Role of Hyperuricemia in Cardiac Diseases: Evidence, Controversies, and Therapeutic Strategies

A combination of red and processed meat intake and polygenic risk score influences the incidence of hyperuricemia in middle-aged Korean adults

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