L-Carnitine may extinguish the COVID19 fire: A review on molecular aspects

Fakhrolmobasheri, Mohammad; Khanahmad, Hossein; Kahlani, Mohammad Javad; Shiravi, Amir Abbas; Shahrokh, Seyedeh Ghazal; Zeinalian, Mehrdad

doi:10.22541/au.165279258.84393618/v1

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…28 The pathophysiology of cardiovascular effects of COVID19 is not completely understood, but most researchers consider cytokine storm and myocardial inflammation as the key contributors to the events. 29 In very recent and novel studies, the neuro-infective properties of SARS-CoV-2 have been discussed. [30][31][32] Steardo et al 30 postulated that like SARS, MERS and other members of coronaviridae, SARS-CoV-2 could infect the CNS and PNS causing neurologic impairment.…”

Section: Molecular Basis Of Sars-cov-2 Infection and Consequent Clini...mentioning

confidence: 99%

“…74 The protective role of CoQ10 in improving viral myocarditis and drug induced cardiotoxicity introduces this supplement as an appropriate choice for the prevention of COVID19 cardiovascular complications which is generally influenced by two factors: cytokine storm, and adverse effects of the medications. 29 The hypercytokinemia caused by SARS-COV-2 infection could lead to fulminant myocarditis 75 , a lethal condition mostly caused by hyper-inflammatory state and cytokine storms, particularly during a viral infection. 76 Evidence has demonstrated that the blood levels of inflammatory cytokines in critically ill patients in the ICU are higher than the patients not admitted to the ICU; additionally, the level of IL-6 has shown to be higher in patients with cardiac injury.…”

Section: Accepted Manuscriptmentioning

confidence: 99%

See 1 more Smart Citation

Coenzyme Q10 and Its Therapeutic Potencies Against COVID-19 and Other Similar Infections: A Molecular Review

et al. 2021

Self Cite

View full text Add to dashboard Cite

Purpose: New lethal Coronavirus infectious disease (COVID19), currently, has been converted to a disastrous pandemic worldwide. As there has been found no definitive treatment for the infection in this review we focused on molecular aspects of Coenzyme-Q10 (CoQ10) and possible therapeutic potencies of CoQ10 against COVID-19 and similar infections. Methods: This is a narrative review in which we used some authentic resources including PubMed, ISI, Scopus, Science Direct, Cochrane, and some preprint databases, the molecular aspects of CoQ10 effects, regarding to the COVID-19 pathogenesis, have been analyzed and discussed. Results: CoQ10 is an essential cofactor in the electron transport chain of the phosphorylative oxidation system. It is a powerful lipophilic antioxidant, anti-apoptotic, immunomodulatory and anti-inflammatory supplement which has been tested for the management and prevention of a variety of diseases particularly diseases with inflammatory pathogenesis. CoQ10 is a strong anti-inflammatory agent which can reduce TNF-α, IL-6, CRP, and other inflammatory cytokines. The cardio-protective role of CoQ10 in improving viral myocarditis and drug induced cardiotoxicity has been determined in different studies. CoQ10 could also improve the interference in the RAS system caused by COVID-19 through exerting anti-Angiotensin II effects and decreasing oxidative stress. CoQ10 passes easily through Brain Blood Barrier (BBB). as a neuroprotective agent CoQ10 can reduce oxidative stress and modulate the immunologic reactions. These properties may help to reduce CNS inflammation and prevent BBB damage and neuronal apoptosis in COVID19 patients. Conclusion: CoQ10 supplementation may prevent the COVID19-induced morbidities with a potential protective role against the deleterious consequences of the disease, further clinical evaluations are encouraged.

show abstract