l-carnitine: Nutrition, pathology, and health benefits

Alhasaniah, Abdulaziz Hassan

doi:10.1016/j.sjbs.2022.103555

Cited by 35 publications

(20 citation statements)

References 184 publications

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Section: Discussionsupporting

confidence: 92%

“…The ApoE − / − HFD group had lower expression levels of carnitine, vitamin B1, tryptophan, and pantothenic acid than ApoE − / − Con group, and that was attenuated by glutamine treatment. Our results of carnitine, vitamin B1, tryptophan, and pantothenic acid are supported by previous study [39–42], although the arachidonic acid is inconsistent with the literature [43]. The expression of meso‐tartaric acid and suberic acid in heart has been rarely reported in previous literature.…”

Section: Discussionsupporting

confidence: 79%

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Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro

Zhang,

Wang,

Sun

et al. 2023

Proteomics

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This study aimed to clarify the role of glutamine in atherosclerosis and its participating mechanism. Forty C57BL/6J mice were divided into wild control (wild Con), ApoE−/− control (ApoE−/− Con), glutamine + ApoE−/−control (Glut + ApoE−/− Con), ApoE−/− high fat diet (ApoE−/− HFD), and glutamine + ApoE−/− HFD (Glut + ApoE−/− HFD) groups. The degree of atherosclerosis, western blotting, and multiomics were detected at 18 weeks. An in vitro study was also performed. Glutamine treatment significantly decreased the degree of aortic atherosclerosis (p = 0.03). O‐GlcNAcylation (O‐GlcNAc), IL‐1β, IL‐1α, and pyruvate kinase M2 (PKM2) in the ApoE−/− HFD group were significantly higher than those in the ApoE−/− Con group (p < 0.05). These differences were attenuated by glutamine treatment (p < 0.05), and aggravated by O‐GlcNA transferase (OGT) overexpression in the in vitro study (p < 0.05). Multiomics showed that the ApoE−/− HFD group had higher levels of oxidative stress regulatory molecules (guanine deaminase [GUAD], xanthine dehydrogenase [XDH]), proinflammatory regulatory molecules (myristic acid and myristoleic acid), and stress granules regulatory molecules (caprin‐1 and deoxyribose‐phosphate aldolase [DERA]) (p < 0.05). These differences were attenuated by glutamine treatment (p < 0.05). We conclude that glutamine supplementation might alleviate atherosclerosis through downregulation of O‐GlcNAc, glycolysis, oxidative stress, and proinflammatory pathway.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 79%

Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro

Zhang,

Wang,

Sun

et al. 2023

Proteomics

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“…L-carnitine has an important role in the management of OADs. Carnitine is an important molecule contributing to energy production and the metabolism of fatty acids [94]. It mediates the transport of fatty acids into the mitochondria.…”

Section: Discussionmentioning

confidence: 99%

Organic Aciduria Disorders in Pregnancy: An Overview of Metabolic Considerations

et al. 2023

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Organic acidurias are a heterogeneous group of rare inherited metabolic disorders (IMDs) caused by a deficiency of an enzyme or a transport protein involved in the intermediary metabolic pathways. These enzymatic defects lead to an accumulation of organic acids in different tissues and their subsequent excretion in urine. Organic acidurias include maple syrup urine disease, propionic aciduria, methylmalonic aciduria, isovaleric aciduria, and glutaric aciduria type 1. Clinical features vary between different organic acid disorders and may present with severe complications. An increasing number of women with rare IMDs are reporting successful pregnancy outcomes. Normal pregnancy causes profound anatomical, biochemical and physiological changes. Significant changes in metabolism and nutritional requirements take place during different stages of pregnancy in IMDs. Foetal demands increase with the progression of pregnancy, representing a challenging biological stressor in patients with organic acidurias as well as catabolic states post-delivery. In this work, we present an overview of metabolic considerations for pregnancy in patients with organic acidurias.

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“…37 As a medically essential amino acid, carnitine contributes to energy production and fatty acid metabolism. 54 Studies on humans and animals indicate that carnitine levels are elevated in the serum of DVT groups. Carnitine also binds to fatty acids to generate acylcarnitine, which is then shuttled into mitochondria to participate in oxidative metabolism.…”

Section: Metabolomic Characterization Of Dvtmentioning

confidence: 99%

Metabolomic profiling of deep vein thrombosis

Jiang,

Yang,

Dang

et al. 2023

Phlebology

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Deep vein thrombosis (DVT) of the lower extremities is one of the most common peripheral vascular diseases, with significant complications and sequelae. Metabolomics aims to identify small molecules in biological samples. It can serve as a promising method for screening compounds that can be used for early disease detection, diagnosis, treatment response prediction, and prognosis. In addition, high-throughput metabolomics screening can yield significant insights into the pathophysiological pathways of DVT. Currently, the metabolomic profiles of DVT have yielded inconsistent expression patterns. This article examines the recent advancements in metabolomic studies of DVT and analyzes the factors that may influence the results.

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l-carnitine: Nutrition, pathology, and health benefits

Cited by 35 publications

References 184 publications

Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro

Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro

Organic Aciduria Disorders in Pregnancy: An Overview of Metabolic Considerations

Metabolomic profiling of deep vein thrombosis

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