2024
DOI: 10.21203/rs.3.rs-3978907/v1
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

L-carnitine Prevents Colistin-induced Mitochondrial Permeability Transition and Reduces the Risk of Acute Kidney Injury in Mice

Sophia Samodelov,
Zhibo Gai,
Francesca De Luca
et al.

Abstract: Colistin is a polymyxin antibiotic currently experiencing renewed clinical interest due to its efficacy in the treatment of multidrug resistant (MDR) bacterial infections. The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment. The mechanism of colistin-induced renal toxicity has been postulated to stem from mitochondrial… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 59 publications
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?