L-carnitine Prevents Colistin-induced Mitochondrial Permeability Transition and Reduces the Risk of Acute Kidney Injury in Mice
Sophia Samodelov,
Zhibo Gai,
Francesca De Luca
et al.
Abstract:Colistin is a polymyxin antibiotic currently experiencing renewed clinical interest due to its efficacy in the treatment of multidrug resistant (MDR) bacterial infections. The frequent onset of acute dose-dependent kidney injury, with the potential of leading to long-term renal damage, has limited its use and hampered adequate dosing regimens, increasing the risk of suboptimal plasma concentrations during treatment. The mechanism of colistin-induced renal toxicity has been postulated to stem from mitochondrial… Show more
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