l-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-γ expression

Zambrano, Sonia; Blanca, Antonio J.; Ruiz-Armenta, María V.; Miguel-Carrasco, José L.; Arévalo, Miguel; Vázquez, María J.; Mate, Alfonso; Vázquez, Carmen M.

doi:10.1016/j.bcp.2012.12.021

Cited by 53 publications

(40 citation statements)

References 46 publications

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“…L-Carnitine has been shown to have anti-oxidant and protective effects against oxidative damage in different organs or tissues, including the kidney [46][47][48], and to modulate PPAR-g expression [49].…”

Section: Oxidative Stressmentioning

confidence: 99%

A study on the effect of cimetidine and l-carnitine on myoglobinuric acute kidney injury in male rats

Estaphan

Eissa

Elattar

et al. 2015

Injury

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Section: Oxidative Stressmentioning

confidence: 99%

A study on the effect of cimetidine and l-carnitine on myoglobinuric acute kidney injury in male rats

Estaphan

Eissa

Elattar

et al. 2015

Injury

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“…L-carnitine and acetyl -L-carnitine: L-carnitine is a nitrogenous constituent of muscle primarily involved in the oxidation of fatty acids in mammals. Animal studies indicate that carnitine has both systemic anti-hypertensive effects as well as anti-oxidant effects in the heart by upregulation of eNOS and PPAR gamma, inhibition of RAAS, modulation of NF-κB and down regulation of NOX2, NOX4, TGF-β and CTGF that reduces cardiac fibrosis [144,145] . Endothelial function, NO and oxidative defense are improved while oxidative stress and BP are reduced [144][145][146][147] .…”

Section: Proteinmentioning

confidence: 99%

“…Animal studies indicate that carnitine has both systemic anti-hypertensive effects as well as anti-oxidant effects in the heart by upregulation of eNOS and PPAR gamma, inhibition of RAAS, modulation of NF-κB and down regulation of NOX2, NOX4, TGF-β and CTGF that reduces cardiac fibrosis [144,145] . Endothelial function, NO and oxidative defense are improved while oxidative stress and BP are reduced [144][145][146][147] . Human studies on the effects of L-carnitine and acetyl-L-carnitine are limited, with minimal to no change in BP [148][149][150][151][152][153] .…”

Section: Proteinmentioning

confidence: 99%

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Houston¹

2014

WJC

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Vascular biology, endothelial and vascular smooth muscle and cardiac dysfunction play a primary role in the initiation and perpetuation of hypertension, cardiovascular disease and target organ damage. Nutrientgene interactions and epigenetics are predominant factors in promoting beneficial or detrimental effects in cardiovascular health and hypertension. Macronutrients and micronutrients can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.© 2014 Baishideng Publishing Group Co., Limited. All rights reserved.Key words: Hypertension; Nutrition; Nutritional supplements; Cardiovascular disease; Vascular biology Core tip: Vascular biology and endothelial dysfunction play a primary roles in hypertension and subsequent cardiovascular disease. Micronutrients, macronutrients and optimal nutrition and nutritional supplements can prevent, control and treat hypertension through numerous mechanisms related to vascular biology. These treatments are complementary to drug therapy. Oxidative stress, inflammation and autoimmune dysfunction initiate and propagate hypertension and cardiovascular disease. There is a role for the selected use of single and component nutraceutical supplements, vitamins, antioxidants and minerals in the treatment of hypertension based on scientifically controlled studies which complement optimal nutrition, coupled with other lifestyle modifications.Houston M. The role of nutrition and nutraceutical supplements in the treatment of hypertension. World J Cardiol 2014; 6(2): 38-66 Available from:

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“…On the other hand, Zambrano et al reported that arterial hypertension-related cardiac fibrosis could be inhibited by L-carnitine through modulation of Peroxisome Proliferator Activated Receptor-γ expression [35].…”

Section: Introductionmentioning

confidence: 99%

Combination of vitamin E and L-carnitine is superior in protection against isoproterenol-induced cardiac injury: histopathological evidence

Huwait

2019

Folia Morphol

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l-Carnitine protects against arterial hypertension-related cardiac fibrosis through modulation of PPAR-γ expression

Cited by 53 publications

References 46 publications

A study on the effect of cimetidine and l-carnitine on myoglobinuric acute kidney injury in male rats

A study on the effect of cimetidine and l-carnitine on myoglobinuric acute kidney injury in male rats

The role of nutrition and nutraceutical supplements in the treatment of hypertension

Combination of vitamin E and L-carnitine is superior in protection against isoproterenol-induced cardiac injury: histopathological evidence

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