L-Carnitine supplementation impairs endothelium-dependent relaxation in mesenteric arteries from rats

Silva, Carmem P. Valgas da; Rojas-Moscoso, Julio Alejandro; Antunes, Edson; Zanesco, Angelina; Priviero, Fernanda

doi:10.3109/13813455.2014.928731

Cited by 3 publications

(3 citation statements)

References 30 publications

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“…The improvement in vascular reactivity, represented by the reduction in the contractile activity (Delbin et al, 2012 ; Okudan et al, 2012 ) and increased relaxing activity (Valgas Da Silva et al, 2014 ) is already well established for the aerobic exercise modality. Concerning the role of strength training in vascular reactivity, three studies have demonstrated improvement in relaxing activity (Figard et al, 2006 ; Harris et al, 2010 ; Araujo et al, 2013 ) and only in one of them the contractile reactivity with a reduction in this activity was measured (Araujo et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Aortic Response to Strength Training and Spirulina platensis Dependent on Nitric Oxide and Antioxidants

et al. 2018

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Studies have shown that supplementation with Spirulina platensis improves vascular reactivity. However, it is unclear whether in association with strength training this effect can be enhanced. Thus, this study aimed to determine the effects of strength training and S. platensis on the reactivity of the aorta from Wistar rat and the possible mechanisms involved. The animals were supplemented with S. platensis and divided into sedentary (SG, SG50, SG150, and SG500) and trained groups (TG, TG50, TG150, and TG500). Nitrite, malondialdehyde (MDA) and antioxidant activity were determined by biochemical assays. To evaluate vascular response, cumulative concentration—response curves to phenylephrine (PHE) and acetylcholine (ACh) were constructed. L-NAME was used to assess the participation of nitric oxide (NO). It was observed that the PHE contractile potency was reduced in TG50, TG150, and TG500 groups compared to SG50, SG150, and SG500 groups, respectively. However, the presence of L-NAME increased the contractile response in all groups. Strength training potentiated the increase in relaxing activity induced by S. platensis, where the pCE50 values of ACh increased in TG150 and TG500. These responses were accompanied by increased nitrite production, MDA reduction and increased antioxidant activity in the aorta of both TG150 and TG500 groups. Thus, the present study demonstrated that combined with strength training, S. platensis potentiates vascular improvement through the participation of NO and reduction of oxidative stress.

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Section: Discussionmentioning

confidence: 99%

Aortic Response to Strength Training and Spirulina platensis Dependent on Nitric Oxide and Antioxidants

et al. 2018

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“… 46 – 48 However, in rats supplemented with L-carnitine, which has antioxidant properties, we have found impaired endothelium-dependent relaxation in mesenteric artery of sedentary and trained lean rats, corroborating our data that exogenous antioxidants may occasionally impair vasodilation. 49 , 50 It is well known that several antioxidants derived from plants and fruits improve endothelial and vascular function by decreasing oxidative stress. 51 However, since NO is a free radical, antioxidants may also scavenge NO.…”

Section: Discussionmentioning

confidence: 99%

“…Vascular relaxation was expressed as the percentage of PE-induced maximum contraction. Potency is given by the pEC 50 which represents the concentration of each drug necessary to cause 50% of maximum relaxation, and it was expressed as −log molar (mol/L). ACh, SNP and PE were purchased from Sigma-Aldrich Co. (St Louis, MO, USA).…”

Section: Methodsmentioning

confidence: 99%

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

Gonçalves¹,

Lázaro²,

Mateo³

et al. 2018

DMSO

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ObjectiveThe aim of the study was to evaluate the effects of supplementation with glucosyl hesperidin (GH), with or without physical training, on body weight, fat depot, glucose and plasma lipids, oxidative status and vascular function of rats fed with high-fat diet (HFD).MethodsAfter weaning, male Wistar rats were fed with an HFD plus fructose for 12 weeks and started receiving oral antioxidant supplementation and/or physical training after the fourth week of diet for eight further weeks. Body weight, epididymal and retroperitoneal fat, plasma glucose and lipids, oxidative status and mesenteric artery reactivity were evaluated.ResultsRats fed with HFD presented higher body weight gain and fat accumulation compared to control rats, while GH supplementation did not influence these parameters. Physical training reduced the body weight gain and fat accumulation and modulated the oxidative status by increasing superoxide dismutase activity and total antioxidant capacity and reducing lipid peroxidation. GH alone decreased lipid peroxidation. However, when given to exercised rats, it impaired the response elicited by physical training. HFD caused endothelial dysfunction, and neither GH nor physical exercise prevented it. Potency of sodium nitroprusside was increased in exercised animals but not in GH-supplemented rats.ConclusionPhysical exercise partially decreased the body fat accumulation, decreased plasma levels of glucose and lipids and improved general oxidative status and endothelium-independent relaxation in mesenteric arteries of rats fed with HFD. GH exhibited benefits only in the oxidative status. However, GH given in association with physical exercise did not cause further changes in addition to those promoted by physical exercise. On the contrary, in exercised animals, GH prevented those changes elicited by physical training in plasma glucose and lipids, oxidative status and endothelium-independent relaxation.

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The Role of L-Carnitine in Kidney Disease and Related Metabolic Dysfunctions

Ulinski

Cirulli²,

Virmani³

2023

Kidney and Dialysis

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Kidney disease is associated with a wide variety of metabolic abnormalities that accompany the uremic state and the state of dialysis dependence. These include altered L-carnitine homeostasis, mitochondrial dysfunctions, and abnormalities in fatty acid metabolism. L-carnitine is essential for fatty acid metabolism and proper mitochondrial function. Deficiency in kidney disease and dialysis is caused by a reduction in endogenous renal synthesis, impaired fatty acid metabolism, a lower intake due to dietary restrictions, and nonselective clearance by the dialysis procedure. Free carnitine levels <40 µmol/L in dialysis patients can lead to dialysis-related complications, such as anemia that is hyporesponsive to erythropoietin therapy, intradialytic hypotension, cardiovascular disease, and skeletal muscle dysfunction manifested as muscle weakness and fatigue. L-carnitine deficiency is also seen in acute kidney injury (AKI) resulting from trauma and/or ischemia, drugs such as cisplatin, and from infections such as covid. A persistent state of L-carnitine deficiency can further damage kidneys and lead to multi-organ failure. Carnitine supplementation has been shown to be safe and effective in improving kidney disease-related complications resulting from drug-induced toxicity, trauma, ischemic injury, infection, and dialysis, by replenishing adequate carnitine levels and rebalancing carnitine homeostasis. In this review, we will examine the protective role of L-carnitine in reducing cellular oxidative damage and maintaining mitochondrial function together with the clinical evidence for its potential use in the management of kidney disease.

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L-Carnitine supplementation impairs endothelium-dependent relaxation in mesenteric arteries from rats

Cited by 3 publications

References 30 publications

Aortic Response to Strength Training and Spirulina platensis Dependent on Nitric Oxide and Antioxidants

Aortic Response to Strength Training and Spirulina platensis Dependent on Nitric Oxide and Antioxidants

Effects of glucosyl-hesperidin and physical training on body weight, plasma lipids, oxidative status and vascular reactivity of rats fed with high-fat diet

The Role of L-Carnitine in Kidney Disease and Related Metabolic Dysfunctions

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