L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

Стовбун, С. В.; Vedenkin, Alexander S.; Bukhvostov, Alexander A.; Королева, Л. С.; Silnikov, Vladimir N.; Kuznetsov, Dmitry A.

doi:10.1016/j.bbrep.2020.100835

Cited by 3 publications

(2 citation statements)

References 18 publications

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“…In our previous works [1][2][3][4][5]18], these algorithms were partially presented and are not described in detail in this study but are our research's focus.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

“…Such studies are compounded by the lack of descriptions of relevant mathematical models of ischemic stroke in scientific literature, as well as drug-specific models of the pharmacokinetics of targeted delivery of PMC16 nanoparticles. All this is required for the development of In Silico instruments for preclinical and clinical studies of the neuroprotective potential of [ 25 Mg 2+ ] 4 PMC16 in the treatment of ischemic stroke [1][2][3][4] (Figure 1).…”

Section: Introduction Formulation Of the Problemmentioning

confidence: 99%

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In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives

Fursov¹,

Fursov²,

Bukhvostov³

et al. 2021

Pharmacogenetics

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Sharp blood circulation disorders are known for their capability to promote such abundant and hardly treatable pathologies as myocardium infarction and the ischemic brain stroke (“insult”). Noteworthy, the stroke — related brain tissue metabolic damages involve an essential ATP deplete clash along with a suppression of brain specific nucleotide — associated kinases and ATP synthase, both Mg2+ — dependent complex enzyme “machineries”. This itself makes the latter’s a legitimate target for some advanced pharmaceuticals as long as the drug — induced overstimulation of corresponding enzymatic activity is the case. Thus, magnetic isotope effects (MIE) of the nuclear spin possessing paramagnetic 25Mg2+ ions might modulate the brain creatine kinase, alfa-glycerophosphate kinase and pyruvate kinase catalytic activities in a way of a remarkable ATP hyperproduction required to compensate the hypoxia caused acute metabolic breakdown. To realize the Magnesium-25 pharmacological potential, a low-toxic amphiphilic cationite nanoparticles were introduced lately. Particularly, the Magnesium — releasing porphyrin-fullerene nanoadduct (cyclohexyl-C60-porphyrin, PMC16) has been proposed to meet expectations dealing with a targeted delivery of 25Mg2+ towards the brain ischemia surrounding areas. In order to optimize a multi-step [25Mg2+]4PMC16 preclinical trial scenario, the In Silico algorithms are to be developed and analyzed. In this study, these algorithms are in a focus with a special emphasize on a novel combination of slightly modified Gompertzian equation systems and a non-Markov population dynamics concept. This In Silico approach takes into account some literature-available patterns of brain hypoxia pathogenesis, the resulted simulation model could be considered as a promising tool for further research on experimental nanopharmacology of the ischemic stroke.

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“…In our previous works [1][2][3][4][5]18], these algorithms were partially presented and are not described in detail in this study but are our research's focus.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Section: Introduction Formulation Of the Problemmentioning

confidence: 99%

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives

Fursov¹,

Fursov²,

Bukhvostov³

et al. 2021

Pharmacogenetics

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Anti-cancer activity of ultra-short single-stranded polydeoxyribonucleotides

et al. 2023

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β-Like DNA polymerases and prospects for their use as targets in chemotherapy of tumors

2023

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DNA polymerases β are enzymes that perform repair of damaged DNA. In the cells of malignant tumors, there is a change in the production and properties of these enzymes, which is accompanied by altered viability of tumor cells. Analysis of the publications available in Russian and international databases (Pubmed, Elsevier) on the structure and properties of DNA polymerases β and their role in cell growth and proliferation, published over the past 20 years, has shown overexpression of genes encoding β-like DNA polymerases in many types of malignant tumors cells. This explains the maintenance of their viability and proliferative activity. Targeted inhibition of β-like DNA polymerases is accompanied by antiproliferative and antitumor effects. Stable paramagnetic isotopes of magnesium (25Mg2+) or other divalent metals (43Ca2+ and 67Zn2+) with uncompensated nuclear spin isotopes, as well as short single-stranded polydeoxyribonucleotides, can be used as promising antitumor pharmacophores.

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L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

Cited by 3 publications

References 18 publications

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives

Anti-cancer activity of ultra-short single-stranded polydeoxyribonucleotides

β-Like DNA polymerases and prospects for their use as targets in chemotherapy of tumors

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L, D-Polydeoxyribonucleotides to provide an essential inhibitory effect on DNA polymerase β of human myeloid leukemia HL60 cells

Cited by 3 publications

References 18 publications

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of 25Mg2+: Releasing Nanocationites - Background and Perspectives

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of 25Mg2+: Releasing Nanocationites - Background and Perspectives

Anti-cancer activity of ultra-short single-stranded polydeoxyribonucleotides

β-Like DNA polymerases and prospects for their use as targets in chemotherapy of tumors

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Product

Resources

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In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives

In Silico Studies on Pharmacokinetics and Neuroprotective Potential of ²⁵Mg²⁺: Releasing Nanocationites - Background and Perspectives