l-dopa effects on preprogramming and control activity in a skilled motor act in Parkinson's disease

Fattapposta, Francesco; Pierelli, Francesco; My, Filomena; Mostarda, M.; Monte, Santo; Parisi, Luca; Serrao, Mariano; Morocutti, Antonino; Amabile, G

doi:10.1016/s1388-2457(01)00723-4

Cited by 14 publications

(9 citation statements)

References 36 publications

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“…Neuroimaging studies [19,38,39] and electroencephalographic recordings [40] have demonstrated that neural activation within these regions normalizes after dopamine administration. This enhancement is thought to underlie the improvement in intensive motor deficits, such as reduced movement amplitude or velocity, present in the off-medicated state (see Introduction).…”

Section: Rapid Adjustments Of Ongoing Movements and Cortico-striatal mentioning

confidence: 99%

Dopamine replacement therapy does not restore the ability of Parkinsonian patients to make rapid adjustments in motor strategies according to changing sensorimotor contexts

Tunik

Feldman

Poizner

2007

Parkinsonism & Related Disorders

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The ability of dopamine replacement to restore rapid motor adjustments in Parkinson's disease was investigated. Medicated and non-medicated patients performed finger-to-nose movements while simultaneously bending the trunk forward, without vision. Trunk motion was blocked unexpectedly, necessitating rapid adjustments in arm trajectories. Patients exhibited irregular hand paths, plateaus in hand velocity, and prolonged movement times which were significantly greater in perturbed trials. Medication improved kinematics but perturbation-induced disturbances persisted and did not approximate the levels of non-perturbed trials nor those of controls. Dopaminergic replenishment in Parkinson's disease may therefore have limited restorative benefits for rapid context-specific motor control.

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Section: Rapid Adjustments Of Ongoing Movements and Cortico-striatal mentioning

confidence: 99%

Dopamine replacement therapy does not restore the ability of Parkinsonian patients to make rapid adjustments in motor strategies according to changing sensorimotor contexts

Tunik

Feldman

Poizner

2007

Parkinsonism & Related Disorders

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“…To test whether patients with PD improved movement performance with practice, i.e., if they showed evidence of motor learning, many investigators used a variety of sequential motor tasks. Patients' performance observed during tracking tasks,8–10 pursuit rotor tasks,11–13 tracing tasks,14–16 a rapid aiming task,17 a sequential buttoning task,18 a tapping task,19 and a bimanual sequential task,20, 21 provided evidence that, in mild‐to‐moderate PD, motor learning is normal,9–12, 14–16, 18, 21 or slightly abnormal 8, 13, 17…”

mentioning

confidence: 99%

Prolonged practice is of scarce benefit in improving motor performance in Parkinson's disease

et al. 2004

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Many studies have addressed practice effects in motor sequences in Parkinson's disease (PD). Most studied short-term practice and showed that treated patients with mild-to-moderate disease achieve normal or slightly abnormal improvement. Less attention has focused on practice effects after prolonged training (days), and the results are inconclusive. Here, we studied the kinematic changes induced by prolonged practice in a group of medicated patients with mild-to-moderate PD and a healthy control group. We did so by analyzing an internally determined sequential arm movement performed as fast and accurately as possible before and after a 2-week training period. After 1-day's practice, movement duration, pause duration, and movement accuracy improved similarly in patients and controls, indicating that patients benefitted normally from short-term practice. After 1-week's practice, movement and pause duration improved further in both groups, whereas movement accuracy remained unchanged. After 2-weeks' practice, healthy controls continued to improve but patients did not, indicating reduced prolonged practice benefit in PD. Because short-term practice benefit on motor performance is thought to be mediated predominantly by cerebellar activation, whereas long-term practice benefit relies predominantly on the basal ganglia, we attribute our findings to the underlying basal ganglia dysfunction in PD. Our study may be relevant for planning and executing rehabilitation programs in these patients.

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“…Previous studies have examined the SPP in children , athletes who were highly trained in a sport (Fattapposta et al, 1996;Fontani et al, 2007), patients with Parkinson's disease (Fattapposta et al, 2002) and children with dyslexia (Chiarenza, 1990;Chiarenza et al, 2014), because it has been thought to reflect evaluation of performance results (Papakostopoulos, 1980). In other words, the SPP is related to evaluation of a motor action (Fontani et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

“…This is not appropriate if the goal is to purely evaluate the appraisal process of participants. It may be even more critical to have an accurate theoretical model if the SPP may be used as a clinical tool (e.g., Chiarenza, 1990;Fattapposta et al, 2002).…”

Section: Discussionmentioning

confidence: 99%

The functional significance of the skilled performance positivity: An update

Hayashi

Taima

et al. 2015

International Journal of Psychophysiology

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l-dopa effects on preprogramming and control activity in a skilled motor act in Parkinson's disease

Cited by 14 publications

References 36 publications

Dopamine replacement therapy does not restore the ability of Parkinsonian patients to make rapid adjustments in motor strategies according to changing sensorimotor contexts

Dopamine replacement therapy does not restore the ability of Parkinsonian patients to make rapid adjustments in motor strategies according to changing sensorimotor contexts

Prolonged practice is of scarce benefit in improving motor performance in Parkinson's disease

The functional significance of the skilled performance positivity: An update

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