L-Dopa response to Cortical Dysfunctions, health related quality of life and Fatigue Severity in Idiopathic Parkinson’s disease

Gul, Amara; Yousaf, Javed

doi:10.12669/pjms.344.14753

Cited by 8 publications

(10 citation statements)

References 13 publications

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“…HRQOL has been assessed and reported in many diseases like dental, ischemic vascular, liver and neurological diseases in Pakistan but they were all done in English language and were done with the assistance of the investigator. 10 , 17 - 19 Up till now none was done with native language spoken in Pakistan.…”

Section: Discussionmentioning

confidence: 99%

Validation and exploratory factor analysis of Urdu Version of Chronic Liver Disease Questionnaire

et al. 2022

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Objective: To present and validate psychometric properties of Urdu version CLDQ, yet another objective was to do exploratory factorial analysis (EFA) of CLDQ Urdu version. Methods: This Cross-sectional Analytical Study was conducted at Dr. Ruth K.M. Pfau Civil Hospital Karachi during the period Nov. 15, 2021 to Jan. 30, 2022. CLDQ Urdu questionnaire was self-administered by the patients. The questionnaire consisted of 29 items and responses were recorded on 7-point Likert type scale. Reliability testing was done by Cronbach’s α, test value of >0.7 is taken as reliable. Exploratory factor analysis (EFA) was conducted with principal component analysis with varimax rotation. Adequacies for conduction of EFA depended on Kaiser-Meyer-Olkin (KMO) value of ≥0.5 and Bartlett’s Test of Sphericity (BTS) of ≤0.05. Mean CLDQ Urdu scores were also compared with Child Class using ANOVA and post-hoc analysis was done. Results: A total of 320 patients were selected after informed consent. All conditions for adequate EFA were met (Cronbach’s α =.949; KMO = .846; BTS ≤.001). Mean CLDQ Urdu score was 156.74 in male and 133.27 in female (p<.001). Child Class-A had best quality of life with score of 186.63 ±6.91 and Child Class-C had the worst with scores of 109.78 ±21.33. EFA resulted in reduction of domains to 4 (Muscular Symptoms, Emotional Symptoms, Abdominal Symptoms & Somnolence) & reduced the number of items from 29 to 11. Conclusion: Urdu CLDQ version is validated in our settings. EFA resulted in reductions in number of domains and items. CLDQ Urdu showed that quality of life decreases significantly with Child Class. doi: https://doi.org/10.12669/pjms.39.1.6602 How to cite this: Hussain SM, Zuberi BF, Rasheed T, Ali FS, Majid E. Validation and exploratory factor analysis of Urdu Version of Chronic Liver Disease Questionnaire. Pak J Med Sci. 2023;39(1):---------. doi: https://doi.org/10.12669/pjms.39.1.6602 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Section: Discussionmentioning

confidence: 99%

Validation and exploratory factor analysis of Urdu Version of Chronic Liver Disease Questionnaire

et al. 2022

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“…There is a clear decrement in HRQoL in adult patients with tracheostomies as measured with generic measures including the EQ-5D-3L/5L [ 29 – 32 ], SF-36 [ 33 , 34 ] and tracheostomy-specific questionnaires [ 35 – 37 ]. Most studies in children dependent on technology for breathing have studied the impact of caregiver or family burden with decrements in HRQoL shown on the PedsQL family impact module [ 25 – 27 ] as well as caregiver HRQoL on the SF-36 [ 38 , 39 ], HUI [ 4 ] and the PTHSI [ 24 , 38 , 40 ].…”

Section: Introductionmentioning

confidence: 99%

Fighting to Breathe and Fighting for Health-Related Quality of Life: Measuring the Impact of Being Dependent on Technology for Breathing on the Child and Their Caregiver

Verstraete,

Booth,

Booth

et al. 2023

Patient

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Background and Objective Medical advancement has enabled children to survive congenital airway anomalies, rare diseases and critical illnesses with medical technology including tracheostomies and long-term ventilation to support breathing. This study aimed to assess (1) the validity of the EQ-TIPS and EQ-5D-Y-3L in children dependent on technology and (2) the impact of caring for these children on the EQ-5D-5L and CarerQoL. Methods Caregivers of children aged 1 month to 18 years completed the EQ-TIPS or EQ-5D-Y-3L, Pediatric Quality of Life Inventory (PedsQL) and Paediatric Tracheostomy Health Status Instrument (PTHSI) to reflect the child’s health. In addition, caregivers self-completed the EQ-5D-5L and CarerQoL. Reports of problems on EQ dimensions were compared across age groups with the Fisher’s exact test. Spearman and Pearson’s correlation coefficients and Kruskal–Wallis H-test were used to explore the association between caregiver and child scores, concurrent validity, and known-group validity of the EQ-TIPS and EQ-5D-Y-3L. Results Responses from 144 caregivers were collected, 66 for children aged 1 month to 4 years completing EQ-TIPS and 78 for children aged 5–18 years completing EQ-5D-Y-3L. The EQ-TIPS showed a higher report of no problems for social interaction for children aged 1–12 months ( p = 0.040) than the older age groups, there were however no differences in the level sum score (LSS) or EQ Visual Analogue Scale scores between the age groups. The EQ-5D-Y-3L showed a significantly less report of problems for mobility ( p = 0.013) and usual activities ( p = 0.006) for children aged 5–7 years compared with children aged 8–12 and children aged 13–18 years. Similarly, the 5–7 years of age group had a significantly lower EQ-5D-Y-3L LSS compared with the older groups (H = 12.08, p = 0.002). The EQ-TIPS and EQ-5D-Y-3L showed moderate-to-strong associations with the PedsQL. EQ-TIPS median LSS was able to differentiate between groups on the clinical prognosis with a better health-related quality of life (HRQoL) in those where weaning from technology is possible compared with those where weaning is not possible (H = 18.98, p = 0.011). The EQ-5D-Y-3L can discriminate between breathing technology, where those with only a tracheostomy reported better HRQoL (H = 8.92, p = 0.012), and between mild and moderate clinical severity (H = 19.42, p < 0.001). Neither the PedsQL nor the PTHSI was able to discriminate between these groups across the age range. Caregiver and child HRQoL scores showed moderate-to-strong associations. Conclusions The EQ-TIPS and EQ-5D-Y-3L showed good validity in children dependent on the technology for breathing. The EQ-TIPS and EQ-5D-Y-3L LSS were all able to differentiate between children with known ...

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“…1 Cognitive decline has been identified as a significant marker of disease progression in patients with PD. 2 Levodopa (L-dopa), 1,3,4 dihydroxy phenylalanine, is a building block which is converted into dopamine by human body. L-dopa can cross blood brain barrier and replaces dopamine being its precursor.…”

Section: Introductionmentioning

confidence: 99%

“…L-dopa can cross blood brain barrier and replaces dopamine being its precursor. Among medical therapies, L-dopa is the most effective treatment to manage symptoms of PD, 3,4 including frontal cortical and subcortical functioning of the brain. 5,6 The rationale of thisstudy was to compare aggression, frontal lobe and task switching performance between PD patients and healthy individuals.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of L-dopa in Treatment of Aggression, Frontal Lobe Cognitive Functioning and Task Switching Deficits in Parkinson’s Disease Patients

Gul

Yousaf

2022

PAFMJ

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Objectives: To assess efficacy of L-dopa treatment on aggression, frontal lobe and task switching deficits in patients with Parkinson’s disease (PD). Study Design: Prospective comparative study. Place and Duration of Study: Bahawal Victoria Hospital and Civil Hospital Bahawalpur, Pakistan, from Apr 2016 to Oct 2017. Methodology: Seventy-five healthy individuals and seventy-five PD patients participated in the study. This study was completed in two testing sessions. Healthy participants had single testing session whereas patients were tested twice (pre and post L-dopa treatment). Participants completed Frontal Assessment Battery, part B TMT, and Buss-Perry Aggression Questionnaire. Results: PD patients (6.13 ± 0.81) showed deficient frontal lobe functioning F (1,48)=14489.66, p<0.001, ηp2=0.99 than healthy individuals (17.93 ± 0.25). Patients (283.05 ± 6.02) had inferior task switching abilities F (1, 48) = 65397.85, p<0.001, ηp2=0.99 than healthy individuals (78.37 ± 3.43). The level of aggression was higher F (1,48)=2369.24, p<0.001, ηp2=0.94 in patients (131.12 ± 12.57) compared with healthy individuals (43.33 ± 9.26). Post L-dopa treatment testing session showed significant improvement in frontal lobe functioning (6.13 ± 0.81 vs. 13.46 ± 1.45), task switching abilities (216.80 ± 13.74 vs. 283.05 ± 6.02) in patients. In addition, aggression was reduced in patients (106.06 ± 1.07 vs. 131.12 ± 12.57). Conclusion: L-dopa was found beneficial to reduce aggression, frontal lobe cognitive and task switching deficits in patients with PD.

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L-Dopa response to Cortical Dysfunctions, health related quality of life and Fatigue Severity in Idiopathic Parkinson’s disease

Cited by 8 publications

References 13 publications

Validation and exploratory factor analysis of Urdu Version of Chronic Liver Disease Questionnaire

Validation and exploratory factor analysis of Urdu Version of Chronic Liver Disease Questionnaire

Fighting to Breathe and Fighting for Health-Related Quality of Life: Measuring the Impact of Being Dependent on Technology for Breathing on the Child and Their Caregiver

Efficacy of L-dopa in Treatment of Aggression, Frontal Lobe Cognitive Functioning and Task Switching Deficits in Parkinson’s Disease Patients

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