L’effet phytoprotecteur de la nigelle (Nigella sativa) contre la toxicité induite par le cadmium chez les rats

Kehili, N.; Saka, S.; Aouacheri, O.

doi:10.1007/s10298-017-1099-y

Cited by 4 publications

(4 citation statements)

References 53 publications

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“…GSH serves as a sensitive marker of oxidative stress and it plays an important role in maintaining the integrity of the cell. Because, it involved in several detoxification reactions in the organism and it is one of the most prominent non-enzymatic antioxidants [29,30]. Many studies have shown a decrease in the GSH level in the small intestine [5] and in liver [2,30] following MTX administration.…”

Section: Parametersmentioning

confidence: 99%

The Investigation of the Oxidative Stress-Related Parameters in High Doses Methotrexate-Induced Albino Wistar Rats

Saka¹,

Aouacheri²

2017

J Bioequiv Availab

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Section: Parametersmentioning

confidence: 99%

The Investigation of the Oxidative Stress-Related Parameters in High Doses Methotrexate-Induced Albino Wistar Rats

Saka¹,

Aouacheri²

2017

J Bioequiv Availab

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“…Black cumin is commonly used for flavour (as a spice) and medicinal purposes. For millennia, these seeds have been used as a natural cure for a variety of ailments and disorders, including asthma, hypertension, diabetes, inflammation, cough, bronchitis, headache, dermatitis, fever, dizziness, and influenza [2,3]. As a diuretic, carminative, lactagogue, and vermifuge, the seeds or their oil are employed [4].…”

Section: Introductionmentioning

confidence: 99%

“…As interest in herbal medicine rises and bacterial illnesses become more resistant to traditional medications, researchers are looking into the antibacterial properties of plant extracts more and more [9,10]. Additionally, there have been reports of the NS seeds having a low level of toxicity [11].…”

Section: Introductionmentioning

confidence: 99%

Antibacterial Activity of the Aqueous and Methanol Extracts of Nigella Sativa Seeds in Mice

Al-Saedi

2023

JKAS

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The purpose of this research was to determine if Nigella sativa (NS) seed extracts have antibacterial properties. In male mice infected intraperitoneally with 0.1 mL of Staphylococcus aureus or Escherichia coli suspensions (Standard McFarland tube No.0.5), the aqueous (AE) and methanol (ME) extracts of NS seed were compared to gentamycin (positive control) and normal saline (negative control). After 24 hours, the infected mice were given varying doses of AE and ME. After 24 hours, a sample of the intraperitoneal fluid that had been aspirated was cultured on a nutrient agar plate. In mice infected with S. aureus and E. coli, the methanol extract of Nigella sativa showed more antibacterial activity than its aqueous extract, especially against gram-negative bacteria. Nigella sativa seed extracts have shown antibacterial activity against both gram-positive and gram-negative bacteria; however this action is dose-dependent.

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“…To protect this vital organ, synthetic hepatoprotective drugs are used, as well as natural substances (plants and agro-resources) with similar effects with the advantage of price and access [2,3]. The cashew apple cake, containing pharmacological molecules of interest ncluding vitamin C and polyphenols [4,5], could be an asset in the search for this protection.…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Aqueous Extract of Cashew Apple Cake (Anacardium occidentale L.) in Rats and Mice

Mamadou

Coulibaly

Innocent

et al. 2022

BJI

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Aims: The aqueous extract of cashew apple cakes, rich in molecules of pharmacological interest, could be used against many diseases. Thus, the aim of the present work is to evaluate its hepatoprotective activity in rats and mice. Methodology: Two batches of rats weighing between 200 and 300 grams, with five rats per batch, were pretreated for eleven days with the aqueous extract of cashew apple cakes at concentrations ranging from 150 to 300 mg.Kg-1 bw, then intoxicated with paracetamol at 2 g.Kg-1 bw, for three days. The blood of these rats was collected and submitted to biochemical analyses. Two batches of mice weighing between 20 and 30 grams, with five mice per batch, were pretreated with the same test substance at concentrations also ranging from 150 to 300 mg.Kg-1 bw, then intoxicated with paracetamol before receiving phenobarbital. Afterwards, their sleep time was evaluated. Results: In rats, paracetamol intoxication materialized by the increase in serum ALT activity ranging from 109±5.19 to 571±20.28 IU.L-1 and that of AST ranging from 144±5.77 to 428±14.19 IU.L-1. Similarly, direct bilirubin increased from 0 to 1.08± 0.58 mg.dl-1. These increases in transaminase activity and bilirubin levels were significantly decreased in rats pretreated with the aqueous extract of cashew apple cake. In mice, the phenobarbital test showed a 29.82 to 38.59% decrease in sleep time in mice pretreated with the aqueous extract of cashew apple cakes. Conclusion: The aqueous extract of cashew apple cakes influencing biochemical parameters such as ALT, AST, bilirubin and sleep time, could therefore be used in the prevention of liver diseases, in traditional medicine.

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L’effet phytoprotecteur de la nigelle (Nigella sativa) contre la toxicité induite par le cadmium chez les rats

Cited by 4 publications

References 53 publications

The Investigation of the Oxidative Stress-Related Parameters in High Doses Methotrexate-Induced Albino Wistar Rats

The Investigation of the Oxidative Stress-Related Parameters in High Doses Methotrexate-Induced Albino Wistar Rats

Antibacterial Activity of the Aqueous and Methanol Extracts of Nigella Sativa Seeds in Mice

Hepatoprotective Activity of Aqueous Extract of Cashew Apple Cake (Anacardium occidentale L.) in Rats and Mice

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