L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model

Williamson, Rachel D.; McCarthy, Fergus P.; Manna, Samprikta; Groarke, Emer; Kell, Douglas B.; Kenny, Louise C.; McCarthy, Cathal

doi:10.1161/hypertensionaha.119.13929

Cited by 63 publications

(42 citation statements)

References 47 publications

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“…A recent paper indicates that ERG relieves the effects seen in a rat model of the pregnancy disorder pre-eclampsia (597) . D. B. K. decided to bring together the multifaceted contributions of the various authors listed.…”

Section: Note Added In Proofmentioning

confidence: 99%

The biology of ergothioneine, an antioxidant nutraceutical

et al. 2020

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Ergothioneine (ERG) is an unusual thio-histidine betaine amino acid that has potent antioxidant activities. It is synthesised by a variety of microbes, especially fungi (including in mushroom fruiting bodies) and actinobacteria, but is not synthesised by plants and animals who acquire it via the soil and their diet, respectively. Animals have evolved a highly selective transporter for it, known as solute carrier family 22, member 4 (SLC22A4) in humans, signifying its importance, and ERG may even have the status of a vitamin. ERG accumulates differentially in various tissues, according to their expression of SLC22A4, favouring those such as erythrocytes that may be subject to oxidative stress. Mushroom or ERG consumption seems to provide significant prevention against oxidative stress in a large variety of systems. ERG seems to have strong cytoprotective status, and its concentration is lowered in a number of chronic inflammatory diseases. It has been passed as safe by regulatory agencies, and may have value as a nutraceutical and antioxidant more generally.

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Section: Note Added In Proofmentioning

confidence: 99%

The biology of ergothioneine, an antioxidant nutraceutical

et al. 2020

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“…Studies have also suggested that ET is protective in preeclampsia, a hypertensive disorder during pregnancy that results in placental ischemia, by protecting against reperfusion-induced oxidative stress and inflammation, preserving mitochondrial function, and reducing hypertension in a reduced uterine perfusion pressure rat model of preeclampsia [ 65 , 66 , 154 ]. Conversely, mice deficient in OCTN1 (whose tissues are completely devoid of ET) are more susceptible to intestinal ischemia and reperfusion injury, with higher inflammatory markers and mortality compared with wild-type animals [ 101 ].…”

Section: How Might Ergothioneine Be Beneficial In Alleviating Covimentioning

confidence: 99%

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Cheah

Halliwell

2020

Antioxidants

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Infection with SARS-CoV-2 causes the coronavirus infectious disease 2019 (COVID-19), a pandemic that has, at present, infected more than 11 million people globally. Some COVID-19 patients develop a severe and critical illness, spurred on by excessive inflammation that can lead to respiratory or multiorgan failure. Numerous studies have established the unique array of cytoprotective properties of the dietary amino acid ergothioneine. Based on studies in a range of in vitro and in vivo models, ergothioneine has exhibited the ability to modulate inflammation, scavenge free radicals, protect against acute respiratory distress syndrome, prevent endothelial dysfunction, protect against ischemia and reperfusion injury, protect against neuronal damage, counteract iron dysregulation, hinder lung and liver fibrosis, and mitigate damage to the lungs, kidneys, liver, gastrointestinal tract, and testis, amongst many others. When compiled, this evidence suggests that ergothioneine has a potential application in the treatment of the underlying pathology of COVID-19. We propose that ergothioneine could be used as a therapeutic to reduce the severity and mortality of COVID-19, especially in the elderly and those with underlying health conditions. This review presents evidence to support that proposal.

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“…Ergothioneine reduces the risk of PE [ 161 ], primarily by mitigating iron-induced oxidative stress. In a rat model of PE, ergothioneine ameliorated hypertension, reduced mitochondrial-specific H 2 O 2 in the kidneys, and increased the fetal weight [ 162 ].…”

Section: Antioxidant Therapies In Pementioning

confidence: 99%

Oxidative Stress and Preeclampsia-Associated Prothrombotic State

et al. 2020

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Preeclampsia (PE) is a common obstetric disease characterized by hypertension, proteinuria, and multi-system dysfunction. It endangers both maternal and fetal health. Although hemostasis is critical for preventing bleeding complications during pregnancy, delivery, and post-partum, PE patients often develop a severe prothrombotic state, potentially resulting in life-threatening thrombosis and thromboembolism. The cause of this thrombotic complication is multi-factorial, involving endothelial cells, platelets, adhesive ligands, coagulation, and fibrinolysis. Increasing evidence has shown that hemostatic cells and factors undergo oxidative modifications during the systemic inflammation found in PE patients. However, it is largely unknown how these oxidative modifications of hemostasis contribute to development of the PE-associated prothrombotic state. This knowledge gap has significantly hindered the development of predictive markers, preventive measures, and therapeutic agents to protect women during pregnancy. Here we summarize reports in the literature regarding the effects of oxidative stress and antioxidants on systemic hemostasis, with emphasis on the condition of PE.

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L-(+)-Ergothioneine Significantly Improves the Clinical Characteristics of Preeclampsia in the Reduced Uterine Perfusion Pressure Rat Model

Cited by 63 publications

References 47 publications

The biology of ergothioneine, an antioxidant nutraceutical

The biology of ergothioneine, an antioxidant nutraceutical

Could Ergothioneine Aid in the Treatment of Coronavirus Patients?

Oxidative Stress and Preeclampsia-Associated Prothrombotic State

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