L'hypoventilation alvéolaire centrale congénitale : Une fenêtre sur les gènes du contrôle respiratoire ?

Gaultier, C; Trang-Pham, H. A.; Dauger, Stéphane; Simonneau, Michel; Gallego, José C.

doi:10.4267/10608/1442

Cited by 3 publications

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Neuronal Control of Breathing: Sex and Stress Hormones

Behan

Kinkead

2011

Comprehensive Physiology

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There is a growing public awareness that hormones can have a significant impact on most biological systems, including the control of breathing. This review will focus on the actions of two broad classes of hormones on the neuronal control of breathing: sex hormones and stress hormones. The majority of these hormones are steroids; a striking feature is that both groups are derived from cholesterol. Stress hormones also include many peptides which are produced primarily within the paraventricular nucleus of the hypothalamus (PVN) and secreted into the brain or into the circulatory system. In this article we will first review and discuss the role of sex hormones in respiratory control throughout life, emphasizing how natural fluctuations in hormones are reflected in ventilatory metrics and how disruption of their endogenous cycle can predispose to respiratory disease. These effects may be mediated directly by sex hormone receptors or indirectly by neurotransmitter systems. Next, we will discuss the origins of hypothalamic stress hormones and their relationship with the respiratory control system. This relationship is 2-fold: (i) via direct anatomical connections to brainstem respiratory control centers, and (ii) via steroid hormones released from the adrenal gland in response to signals from the pituitary gland. Finally, the impact of stress on the development of neural circuits involved in breathing is evaluated in animal models, and the consequences of early stress on respiratory health and disease is discussed.

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Neuronal Control of Breathing: Sex and Stress Hormones

Behan

Kinkead

2011

Comprehensive Physiology

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Sex‐Specific Effects of Stress on Respiratory Control: Plasticity, Adaptation, and Dysfunction

Tenorio‐Lopes

Kinkead

2021

Comprehensive Physiology

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As our understanding of respiratory control evolves, we appreciate how the basic neurobiological principles of plasticity discovered in other systems shape the development and function of the respiratory control system. While breathing is a robust homeostatic function, there is growing evidence that stress disrupts respiratory control in ways that predispose to disease. Neonatal stress (in the form of maternal separation) affects "classical" respiratory control structures such as the peripheral O 2 sensors (carotid bodies) and the medulla (e.g., nucleus of the solitary tract). Furthermore, early life stress disrupts the paraventricular nucleus of the hypothalamus (PVH), a structure that has emerged as a primary determinant of the intensity of the ventilatory response to hypoxia. Although underestimated, the PVH's influence on respiratory function is a logical extension of the hypothalamic control of metabolic demand and supply. In this article, we review the functional and anatomical links between the stress neuroendocrine axis and the medullary network regulating breathing. We then present the persistent and sex-specific effects of neonatal stress on respiratory control in adult rats. The similarities between the respiratory phenotype of stressed rats and clinical manifestations of respiratory control disorders such as sleep-disordered breathing and panic attacks are remarkable. These observations are in line with the scientific consensus that the origins of adult disease are often found among developmental and biological disruptions occurring during early life. These observations bring a different perspective on the structural hierarchy of respiratory homeostasis and point to new directions in our understanding of the etiology of respiratory control disorders.

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Syndrome d'Ondine

Trang

2001

Archives de Pédiatrie

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L'hypoventilation alvéolaire centrale congénitale : Une fenêtre sur les gènes du contrôle respiratoire ?

Cited by 3 publications

References 0 publications

Neuronal Control of Breathing: Sex and Stress Hormones

Neuronal Control of Breathing: Sex and Stress Hormones

Sex‐Specific Effects of Stress on Respiratory Control: Plasticity, Adaptation, and Dysfunction

Syndrome d'Ondine

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