Standing in a proud tradition of research with constant development in numerous medical fields, the feeling of "standing" is more appropriate than "progressing" regarding the research of diagnosing acute intestinal necrosis (AIN). After a century where the prognosis and treatment have evolved for AIN patients, the statement of Cokkinis remains painfully relevant due to the diagnostic process. The search for a blood-based biomarker has for decades been a desert walk. Similarly, despite "sensitivity and specificity rates of 1.00" of an abdominal CT scan with respect to AIN, no general change in mortality has occurred.Growing from this painful experience in my own clinical work with AIN patients, this study is a humble supplement to the fight against its terribly high mortality rate.This study explores radiological findings in the most difficult AIN patients and tries to settle research questions in some proposed blood-based biomarkers and to add support to other biomarker research through 3 studies in AIN patients.