l-Ornithine attenuates corticotropin-releasing factor-induced stress responses acting at GABAA receptors in neonatal chicks

Kurata, Kanako; Shigemi, Kazutaka; Tomonaga, Shozo; Aoki, Mami; Denbow, D. Michael; Furuse, Mitsuhiro

doi:10.1016/j.neuroscience.2010.10.076

Cited by 25 publications

(20 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In WKY rats, numerous amino acids displayed lower concentration compared with WIS rats. Especially, proline, tyrosine, ornithine, alanine and arginine having the sedative effect under the stressful conditions (Hamasu et al, 2009(Hamasu et al, , 2010Kabuki et al, 2009;Kurata et al, 2011;Kurauchi et al, 2006;Suenaga et al, 2008) were decreased in the brain of WKY rats. The behavioral characteristics in WKY rats may be induced by the abnormal metabolism of these functional amino acids having the sedative effect, because WKY rats are hyper-responsive to stress (TejaniButt et al, 2003).…”

Section: Discussionmentioning

confidence: 89%

Chronic imipramine treatment differentially alters the brain and plasma amino acid metabolism in Wistar and Wistar Kyoto rats

Nagasawa

Otsuka

Yasuo

et al. 2015

European Journal of Pharmacology

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 89%

Chronic imipramine treatment differentially alters the brain and plasma amino acid metabolism in Wistar and Wistar Kyoto rats

Nagasawa

Otsuka

Yasuo

et al. 2015

European Journal of Pharmacology

View full text Add to dashboard Cite

“…7,10,15,16 However, whether orally administered L-ornithine can reduce stress was unknown. To attenuate the stress response, orally administered L-ornithine must first be transported into the brain.…”

Section: Discussionmentioning

confidence: 99%

Orally administeredl-ornithine elevates brainl-ornithine levels and has an anxiolytic-like effect in mice

Kurata

Nagasawa

Tomonaga

et al. 2011

Nutritional Neuroscience

View full text Add to dashboard Cite

Intracerebroventricular injection of L-ornithine has demonstrated sedative and hypnotic effects in neonatal chicks exposed to acute stressful conditions. However, whether orally administered L-ornithine can reduce acute mental stress remains to be defined. To clarify the nutritional importance of L-ornithine in controlling the stress response, in Experiment 1 we first investigated whether orally administered L-ornithine can be transported into the brain of mice. Mice were orally administered L-ornithine (3 mmol/water 10 ml/kg, per os). L-Ornithine levels were significantly elevated in the cerebral cortex and hippocampus at 30 and 60 minutes post-administration. In Experiment 2, the effect of orally administered L-ornithine (0, 0.1875, 0.75 and 3 mmol/water 10 ml/kg, per os) on anxiety-like behavior in mice exposed to the elevated plus-maze test was examined at 30 minutes post-administration. There was a significant increase in the percentage of time spent and entries in the open arms in the group receiving 0.75 mmol of L-ornithine compared to the control group. Furthermore, locomotion activity in a novel environment was not significantly changed between the control group and 0.75 mmol of L-ornithine group in Experiment 3. Therefore, it appears that orally administrated L-ornithine is bioavailable to the rodent brain and reduces anxiety-like behavior as demonstrated by the elevated plus-maze test.

show abstract

“…In particular, much attention has been paid to the regulation of physiology and behaviour, including stress responses (Asechi et al, 2006;Hamasu et al, 2009a;2009b;Kurauchi et al, 2010;Kurata et al, 2011;Erwan et al, 2014). Therefore, relationships between stress and amino acid metabolism may partly explain the physiological state of the individual.…”

Section: Introductionmentioning

confidence: 99%

Changes in free amino acid concentrations in the blood, brain and muscle of heat-exposed chicks

Ito

Erwan

Nagasawa

et al. 2014

British Poultry Science

Self Cite

View full text Add to dashboard Cite

An experiment was conducted to analyse the changes in free amino acid concentrations in the blood, brain and muscle of chicks in response to 15 or 30 min exposure to high ambient temperature (HT). Food intake and body weight were not affected, while rectal temperature was significantly increased by short-term HT exposure. Several free amino acid concentrations increased in the blood, brain and muscle even with short-term HT, whereas levels of a few amino acids declined significantly. As well as the nonessential amino acids, essential amino acids also significantly increased with exposure to HT. 3-Methylhistidine, a marker of proteolysis, significantly declined in the muscle of HT chicks, implying a reduction of protein breakdown under HT. These results indicate that alteration of protein metabolism may occur in chicks even with short-term heat exposure.

show abstract

l-Ornithine attenuates corticotropin-releasing factor-induced stress responses acting at GABAA receptors in neonatal chicks

Cited by 25 publications

References 32 publications

Chronic imipramine treatment differentially alters the brain and plasma amino acid metabolism in Wistar and Wistar Kyoto rats

Chronic imipramine treatment differentially alters the brain and plasma amino acid metabolism in Wistar and Wistar Kyoto rats

Orally administeredl-ornithine elevates brainl-ornithine levels and has an anxiolytic-like effect in mice

Changes in free amino acid concentrations in the blood, brain and muscle of heat-exposed chicks

Contact Info

Product

Resources

About