l-Ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism

Sugino, Tomohiro; Shirai, Toshizumi; Kajimoto, Yoshitaka; Kajimoto, Osami

doi:10.1016/j.nutres.2008.08.008

Cited by 122 publications

(89 citation statements)

References 19 publications

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“…However, from this viewpoint, few previous studies have examined the effects of L-ornithine ingestion. Among them, Sugino et al (2008) examined the effect of L-ornithine ingestion on the recovery from physical fatigue induced by extended exercise and accentuation of lipid metabolism, and reported that fatigue recovery and accentuation of lipid metabolism are identified by L-ornithine ingestion. However, the following two mixed viewpoints were found in Sugino et al's study: the above stated fatigue reduction because of accentuating ammonia metabolism, and the accentuating lipid metabolism, which means the fatigue inhibition with the increase of energy substrate during exercise.…”

Section: Introductionmentioning

confidence: 99%

The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise

et al. 2010

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Objectives: L-ornithine has an important role in ammonia metabolism via the urea cycle. This study aimed to examine the effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise. Subjects/Methods: In all, 14 healthy young adults (age: 22.2 ± 1.0 years, height: 173.5 ± 4.6 cm, body mass: 72.5 ± 12.5 kg) who trained regularly conducted incremental exhaustive ergometer bicycle exercises after L-ornithine hydrochloride supplementation (0.1 g/kg, body mass) and placebo conditions with a cross-over design. The exercise time (sec) of the incremental ergometer exercise, exercise intensity at exhaustion (watt), maximal oxygen uptake (ml per kg per min), maximal heart rate (beats per min) and the following serum parameters were measured before ingestion, 1 h after ingestion, just after exhaustion and 15 min after exhaustion: ornithine, ammonia, urea, lactic acid and glutamate. All indices on maximal aerobic capacity showed insignificant differences between both the conditions. Results: Plasma ammonia concentrations just after exhaustion and at 15 min after exhaustion were significantly more with ornithine ingestion than with placebo. Plasma glutamate concentrations were significantly higher after exhaustion with ornithine ingestion than with placebo. Conclusions: It was suggested that, although the ingestion of L-ornithine hydrochloride before the exercise cannot be expected to improve performance, it does increase the ability to buffer ammonia, both during and after exercise.

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Section: Introductionmentioning

confidence: 99%

The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise

et al. 2010

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“…In pharmacological therapy, Orn is used to decrease blood ammonia levels and reduce the symptoms of hepatic encephalopathy associated with liver cirrhosis (6). In addition, many human studies have indicated several beneficial effects of Orn, including attenuation of fatigue evoked by exercise or alcohol consumption (7,8), stimulation of growth hormone release (9), and improvements in sleep disturbance (10,11). Furthermore, a report indicated that the addition of Orn to a basal diet induced the blood growth hormone level and the rate of protein synthesis in the liver and gastrocnemius muscle (12).…”

Section: Introductionmentioning

confidence: 99%

The Effect of L-Ornithine on the Phosphorylation of mTORC1 Downstream Targets in Rat Liver

Kokubo

Maeda

Tazumi

et al. 2015

JFN

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A non-protein amino acid, L-ornithine (Orn), has been shown to stimulate the urea cycle and tissue protein synthesis in the liver. The purpose of the current study was to assess whether Orn affects the mammalian target of rapamycin (mTOR) complex 1 (mTORC1) pathway, which is involved in protein synthesis. Primary cultured cells isolated from Wistar rat liver were incubated in an amino acid-free medium, followed by addition of Orn for 3 h. The cell lysate was subjected to immunoblotting to evaluate the phosphorylation of downstream targets of mTORC1, including p70S6K, S6, and 4EBP1. To assess the involvement of mTORC1 for the effect of Orn, the cells were pretreated with the mTOR inhibitor rapamycin before the addition of Orn and the cell lysate was subjected to immunoblotting. We next examined whether the effects of Orn were exerted in vivo. Orn was orally administered to 18 h food-deprived rats, the blood and the livers were collected at 1 and 3 h after administration for immunoblotting. Orn treatment for primary cultured cells for 3 h enhanced the phosphorylation of p70S6K, S6, and 4EBP1. In addition, rapamycin blocked the effects of Orn completely (p70S6K and S6) or partially (4EBP1). The oral administration of Orn to the rat also augmented the phosphorylation of mTORC1 downstream targets notably in S6 at 1 h. Our findings demonstrate that Orn has the potential to induce the phosphorylation of downstream targets of mTORC1 in the rat liver. This may be mediated by the augmentation of mTORC1 activity.

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“…Its intake has been recommended as a nutritional supplement for its antifatigue effect [1,2]. N 5 -Ornithine derivatives showed their potential as orally active non-peptide fibrinogen receptor antagonists [3] and selective prostaglandin EP 4 receptor antagonists [4].…”

Section: Introductionmentioning

confidence: 99%

N2-tert-Butoxycarbonyl-N5-[N-(9-fluorenylmethyloxycarbonyl)-2-aminoethyl]-(S)-2,5-diaminopentanoic Acid

Maity

Strömberg

2014

Molbank

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l-Ornithine supplementation attenuates physical fatigue in healthy volunteers by modulating lipid and amino acid metabolism

Cited by 122 publications

References 19 publications

The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise

The effect of L-ornithine hydrochloride ingestion on performance during incremental exhaustive ergometer bicycle exercise and ammonia metabolism during and after exercise

The Effect of L-Ornithine on the Phosphorylation of mTORC1 Downstream Targets in Rat Liver

N2-tert-Butoxycarbonyl-N5-[N-(9-fluorenylmethyloxycarbonyl)-2-aminoethyl]-(S)-2,5-diaminopentanoic Acid

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