L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH4

Wang, Zhengjun; Chen, Cheng; Yang, Xiaoyu; Zhang, Chen

doi:10.1371/journal.pone.0250126

Cited by 18 publications

(14 citation statements)

References 44 publications

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“…Arg plays an important role in regulating human immune functions and improving immunity [ 81 ]. Trp can regulate the metabolic process of lung cancer [ 82 ]. It could be seen that the six amino acids with relatively large positive loads in PC2 have, more or less, certain effects on regulating the body, so the second principal component was named the regulatory principal component here.…”

Section: Resultsmentioning

confidence: 99%

Amino Acid Profiles and Nutritional Evaluation of Fresh Sweet–Waxy Corn from Three Different Regions of China

Hong

Shen

et al. 2022

Nutrients

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This study conducted a comparative analysis of the amino acid compositions of Chinese Huangnuo 9 fresh sweet–waxy corn from three different provinces in China—Inner Mongolia, Jilin, and Heilongjiang Province. Moreover, we established a nutritive evaluation system based on amino acid profiles to evaluate, compare, and rank the fresh sweet–waxy corn planted in different regions. A total of 17 amino acids were quantified, and the amino acid composition of fresh sweet–waxy corn was analyzed and evaluated. The amino acid quality was determined by the amino acid pattern spectrum, chemical evaluations (including CS, AAS, EAAI, BV, U(a,u), NI, F, predict PER, and PDCAAS), flavor evaluation, amino acid matching degree evaluation, and the results of the factor analysis. The results showed that the protein content of fresh corn 1−1 from Inner Mongolia was the highest (40.26 ± 0.35 mg/g), but the factor analysis results, digestion, and absorption efficiency of fresh corn 1−2 were the best. The amino acid profile of fresh corn 1−1 was closest to each evaluation’s model spectrum. The results of the diversity evaluations in fresh corn 3−2 were the best, and fresh corn 3−3 had the most essential amino acid content. A total of 17 amino acids in fresh corn were divided into three principal component factor analyses: functional principal components (Leu, Pro, Glu, His, Ile, Ser, Met, Val, Tyr, Thr), regulatory principal components (Lys, Gly, Ala, Asp, Arg, Trp), and protection principal components (Phe). The scores of the three principal components and the comprehensive score in fresh corn 1−2 were all the highest, followed by 3−3 and 1−1. The amino acid nutritional values of fresh corn 1−2 were the highest in 12 samples.

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Section: Resultsmentioning

confidence: 99%

Amino Acid Profiles and Nutritional Evaluation of Fresh Sweet–Waxy Corn from Three Different Regions of China

Hong

Shen

et al. 2022

Nutrients

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“…L-phenylalanine could improve vascular tetrahydrobiopterin, restores NO, reduce superoxide and enhances vascular function in spontaneously hypertensive rats by activating the protein complex (GCH1-GFRP) involved in the biosynthesis of tetrahydrobiopterin [ 55 ]. Additionally, L-phenylalanine could attenuate high salt-induced hypertension in Dahl SS rats [ 56 ]. Studies have found that PAGln can enhance the stimulatory response of platelets to various agonists and intracellular calcium release [ 57 ].…”

Section: Discussionmentioning

confidence: 99%

Antihypertensive Activity of Milk Fermented by Lactiplantibacillus plantarum SR37-3 and SR61-2 in L-NAME-Induced Hypertensive Rats

Yuan

Chen

et al. 2022

Foods

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Probiotic fermented milk can lower the incidence rate of hypertension and is beneficial to the regulation of the intestinal microecology. However, the underlying molecular mechanism remains elusive. Here, we evaluated the role of the gut microbiota and its metabolites in the antihypertensive effect of milk fermented by the Lactiplantibacillus plantarum strains SR37-3 (PFM-SR37-3) and SR61-2 (PFM-SR61-2) in Ng-nitro-L-arginine methyl ester induced hypertensive rats. The results showed that PFM-SR37-3 and PFM-SR61-2 intervention significantly lowered the blood pressure (BP) of NG-nitro-L-arginine methyl ester induced hypertensive rats and attenuated renal injury. In particular, long-term administration of PFM inhibited a progressive elevation in SBP (170.22 ± 8.40 and 133.28 ± 6.09 by model group and PFM-SR37-3 treated model group, respectively, at the end of the 4 weeks; p < 0.01 PFM-SR37-3 treated model group versus model group) and DBP (133.83 ± 5.91 and 103.00 ± 6.41 by model group and PFM-SR37-3 treated model group, respectively, at the end of the 4 weeks; p < 0.01 PFM-SR37-3 treated model group versus model group). PFM-SR37-3 and PFM-SR61-2 reshaped the gut microbiome and metabolome, and especially regulated the metabolic levels of L-phenylalanine, L-methionine and L-valine in the intestine and blood circulation. The analysis of the target organ’s aortic transcriptome indicated that the protective effects of PFM-SR37-3 and PFM-SR61-2 were accompanied by the modulation of the BP circadian rhythm pathway, which was conducive to cardiovascular function. Vascular transcriptomic analysis showed that circadian rhythm and AMPK might be potential targets of hypertension. In addition, the ACE inhibition rates of Lactiplantibacillus plantarum SR37-3 and Lactiplantibacillus plantarum SR61-2 in vitro were 70.5% and 68.9%, respectively. Our research provides new insights into novel and safe options for hypertension treatment.

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“…Additionally, GCH1-mediated BH4 production prevents ferroptosis by inhibiting lipid peroxidation ( Kraft et al, 2020 ; Hu Q. et al, 2022 ). In the hypertension model reported by Wang et al (2021) , the antihypertensive effect of L-phenylalanine could be mediated by enhancing BH4 biosynthesis and reducing superoxide levels produced by NO synthase, thereby reducing ROS and improving NO levels and protecting blood vessels and renal function. Hence, the GCH1-BH4 signaling pathway, as an endogenous antioxidant pathway, inhibits iron death through a mechanism independent of the GPX4/GSH system ( Kuang et al, 2020 ; Wei et al, 2020 ).…”

Section: Neuronal Ferroptosismentioning

confidence: 99%

Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage

Chen

Liu

et al. 2022

Front. Cell. Neurosci.

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Subarachnoid haemorrhage (SAH) is a common cerebrovascular disease with high disability and mortality rates worldwide. The pathophysiological mechanisms involved in an aneurysm rupture in SAH are complex and can be divided into early brain injury and delayed brain injury. The initial mechanical insult results in brain tissue and vascular disruption with hemorrhages and neuronal necrosis. Following this, the secondary injury results in diffused cerebral damage in the peri-core area. However, the molecular mechanisms of neuronal death following an aneurysmal SAH are complex and currently unclear. Furthermore, multiple cell death pathways are stimulated during the pathogenesis of brain damage. Notably, particular attention should be devoted to necrosis, apoptosis, autophagy, necroptosis, pyroptosis and ferroptosis. Thus, this review discussed the mechanism of neuronal death and its influence on brain injury after SAH.

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L-phenylalanine attenuates high salt-induced hypertension in Dahl SS rats through activation of GCH1-BH4

Cited by 18 publications

References 44 publications

Amino Acid Profiles and Nutritional Evaluation of Fresh Sweet–Waxy Corn from Three Different Regions of China

Amino Acid Profiles and Nutritional Evaluation of Fresh Sweet–Waxy Corn from Three Different Regions of China

Antihypertensive Activity of Milk Fermented by Lactiplantibacillus plantarum SR37-3 and SR61-2 in L-NAME-Induced Hypertensive Rats

Molecular mechanisms of neuronal death in brain injury after subarachnoid hemorrhage

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