L-PRF y Ciclo Celular. Revisión Narrativa

Abstract

RESUMEN: Los concentrados plaquetarios han emergido como un potencial material regenerativo, utilizado de forma aislada o como andamiaje para otros materiales de injerto. Son extractos de sangre, obtenidos después de procesar una muestra de sangre completa, mediante centrifugación. El primer reporte data de 1970, con un CP utilizado como pegamento para mejorar cicatrización de heridas de piel. En 1998, se usaron en cirugía oral y maxilofacial. Desde entonces, se han desarrollado diferentes técnicas y una variedad de preparaciones. Entre ellas, cabe destacar el plasma rico en plaquetas, fibrina rica en plaquetas y leucocitos (L-PRF) y plasma rico en factores de crecimiento (PRGF). El desarrollo de estos biomateriales, se debe en parte, a la posibilidad de alterar la concentración de mediadores químicos liberados en una lesión que provoque la formación de un coágulo, que pueda madurar conforme transcurran las fases del proceso inflamatorio y concluya con la regeneración íntegra del tejido dañado. El objetivo de este manuscrito fue describir las principales vías de señalización intracelular que se activan en presencia del L-PRF en cirugía oral, y sus efectos en la regulación del ciclo celular. PALABRAS CLAVE: factores de crecimiento; receptores de citoquinas; agentes angiogénicos moduladores; periodoncia; endodoncia regenerativa; plaquetas ricas en fibrina; medicina regenerativa.

Infiltration of Plasma Rich in Growth Factors for the Treatment of Temporomandibular Joint Disorders: A Comprehensive Review

“…Most studies (80%) show that the use of plasma rich in growth factors (PRGF) was effective and safe as a treatment for joint disorders, whether in the knee, temporomandibular joint, ankle, hip, lumbar facet joint or shoulder, although there are few studies showing the in a coordinated manner their proliferation and differentiation, a quality of great importance since by means of platelet concentrates we can guide cellular proliferation of articular cartilage, in order to regenerate the tissue as a consequence of degenerative disorders of the joint, in addition to serving as viscosupplementation and maintaining the homeostasis of the articular capsule, maintaining a balance between the articular surfaces; This translates into a decrease in joint symptomatology and prevents further morphological alteration of the joints [8][9][10][11][12].…”

“…As mentioned by Picco, et al, an ideal growth factor in the temporomandibular joint is one that is able to regenerate cartilage regardless of the patient's age and stop the progression of inflammatory joint pathology [8,12,13].…”

“…It should be emphasized that although the use of growth factors are new for infiltration of the temporomandibular joint, it is necessary to take into account that the infiltration technique may have modifications; this is due to the fact that as it is already known, infiltration is always performed in the upper space of the joint capsule since it is anatomically wider, it is where the inflammatory potential is located and it is the easiest area to access in a blind technique; However, it has been shown that infiltration in the inferior space improves viscosupplementation and mandibular movement, as well as eliminates adhesions between the inelastic zone of the disc in its inferior part [15]. [12].…”