l-Proline-catalyzed diastereoselective synthesis of cis-isoquinolonic acids and evaluation of their neuroprotective effects

A speedy route to sterically encumbered, benzene-fused derivatives of privileged, naturally occurring hexahydropyrrolo[1,2-b]isoquinoline

“…Employment of homophthalic anhydride (HPA) in this reaction delivers medicinally important, most often trans -configured [ 6 – 7 ] tetrahydroisoquinolonic acids 2 ( Fig. 1 ) which have found utility as probe compounds or therapeutic agents in diverse areas such as neuroprotection [ 8 ], diabetes [ 9 ], and cancer [ 10 ].…”

Immobilized Pd on (S)‐methyl histidinate‐modified multi‐walled carbon nanotubes: a powerful and recyclable catalyst for Mizoroki–Heck and Suzuki–Miyaura C–C cross‐coupling reactions in green solvents and under mild conditions

“…However, the preparation of most reported ligands seems rather laborious and time‐consuming. Therefore, employing available biomolecules such as amino acids, alkaloids and nucleic acids and supporting them on solid substrates is highly favorable . Among them, histidine is an applicable amino acid in catalytic systems, its key features including air‐stability, low cost, nontoxicity and easy accessibility (via chemical synthesis) that make it a more efficient ligand or nanometal species stabilizer for practical applications compared with other well‐established ligands …”

A new nano‐Fe3O4‐supported organocatalyst based on 3,4‐dihydroxypyridine: an efficient heterogeneous nanocatalyst for one‐pot synthesis of pyrazolo[3,4‐b]pyridines and pyrano[2,3‐d]pyrimidines

“…Among the strategies used, the preparation of solid‐supported organocatalysts is potentially a highly useful method to obtain more efficient catalytic systems for the synthesis of fine chemicals under especially simple, mild and environmentally benign conditions . So far, pyridines, alkaloids, amino acids and their derivatives, pyrrolidine, biguanidine, piperidine and sulfamic acid are the most used materials supported on solid substrate organocatalysts . In this regard, nano‐Fe 3 O 4 has attracted much attention due to its unique physical properties such as high surface area, excellent thermal and chemical stability, low toxicity and potential applications.…”