l-Stepholidine reduced l-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease

Mo, Jiao; Hai, Zhang; Yu, Lei-Ping; Sun, Peihua; Jin, Guo-Zhang; Zhen, Xuechu

doi:10.1016/j.neurobiolaging.2008.06.017

Cited by 38 publications

(21 citation statements)

References 48 publications

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“…Surgery was performed as previously described [24], with minor modifications. Briefly, after assessing their preoperative rotation behavior to confirm that there were no abnormal rats, the rats were anesthetized using sodium pentobarbital (30 mg/kg, i.p.).…”

Section: Unilateral 6-ohda Lesionmentioning

confidence: 99%

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

Pan

Chen

Huang

et al. 2015

Neuroscience Letters

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Section: Unilateral 6-ohda Lesionmentioning

confidence: 99%

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

Pan

Chen

Huang

et al. 2015

Neuroscience Letters

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“…The surgery was conducted as described before [19], with minor modifications. Briefly, the rats were anesthetized with sodium pentobarbital anesthesia (30 mg/kg, i.p.)…”

Section: Medial Forebrain Bundle Lesion By Unilateral 6-ohda Injectionmentioning

confidence: 99%

A potential target for the treatment of Parkinson's disease: Effect of lateral habenula lesions

Han

Jin

Song

et al. 2014

Parkinsonism & Related Disorders

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“…induced dyskinesia in the 6-OHDA-induced rat model of PD. 116 GPS and the ethanol extract from G. pentaphyllum also attenuate the development of l-DOPA-induced dyskinesia by modulating the biomarker activities of delta-FosB expression and extracellular signal-regulated kinases (ERK1/2) phosphorylation in the 6-OHDA-induced rat model of PD. 117 Effects on l-DOPA-induced memory dysfunctions or cognitive disorders Lycopene exerts protective effects on the cognitive decline that is observed in the rotenone-induced model of PD.…”

Section: Effects On Mptp-induced Anxiety Disordersmentioning

confidence: 99%

Animal models of Parkinson's disease and their applications

Park

Zhao²,

Lee

2016

JPRLS

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Abstract:Parkinson's disease (PD) is a progressive neurodegenerative disorder that occurs mainly due to the degeneration of dopaminergic neuronal cells in the substantia nigra. l-3,4-Dihydroxyphenylalanine (l-DOPA) is the most effective known therapy for PD. However, chronic l-DOPA administration results in a loss of drug efficacy and irreversible adverse effects, including l-DOPA-induced dyskinesia, affective disorders, and cognitive function disorders. To study the motor and non-motor symptomatic dysfunctions in PD, neurotoxin and genetic animal models of PD have been widely applied. However, these animal models do not exhibit all of the pathophysiological symptoms of PD. Regardless, neurotoxin rat and mouse models of PD have been commonly used in the development of bioactive components from natural herbal medicines. Here, the main animal models of PD and their applications have been introduced in order to aid the development of therapeutic and adjuvant agents.

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l-Stepholidine reduced l-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease

Cited by 38 publications

References 48 publications

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

A potential target for the treatment of Parkinson's disease: Effect of lateral habenula lesions

Animal models of Parkinson's disease and their applications

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l-Stepholidine reduced l-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease

Cited by 38 publications

References 48 publications

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

Neuroprotective effect of combined therapy with hyperbaric oxygen and madopar on 6-hydroxydopamine-induced Parkinson’s disease in rats

A potential target for the treatment of Parkinson's disease: Effect of lateral habenula lesions

Animal models of Parkinson&#39;s disease and their applications

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Animal models of Parkinson's disease and their applications