L‐theanine ameliorate depressive‐like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic–cortical–striatal–pallidal–thalamic‐circuit related brain regions

Shen, Manjun; Yang, Yi; Ying, Wantao; Zhang, Beibei; Wu, Haishan; Wang, Lu; Tang, Hui; Chen, Jindong

doi:10.1002/ptr.6237

Cited by 49 publications

(34 citation statements)

References 63 publications

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“…A recent study measured the effect of L-theanine (2 mg/kg) on 5-HT, NE and DA levels in an animal model of depression [111]. Measurements were taken in the limbic-cortical-striatal-pallidal-thalamic (LCSPT) circuit, which included the prefrontal cortex (PFC), nucleus accumbens (NAC), striatum (ST), amygdala, and hippocampus (HIP).…”

Section: Mechanistic Considerationsmentioning

confidence: 99%

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Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption

2019

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This article is a comprehensive review of the literature pertaining to the antidepressant effects and mechanisms of regular tea consumption. Meta-data supplemented with recent observational studies were first analyzed to assess the association between tea consumption and depression risk. The literature reported risk ratios (RR) were 0.69 with 95% confidence intervals of 0.62–0.77. Next, we thoroughly reviewed human trials, mouse models, and in vitro experiments to determine the predominant mechanisms underlying the observed linear relationship between tea consumption and reduced risk of depression. Current theories on the neurobiology of depression were utilized to map tea-mediated mechanisms of antidepressant activity onto an integrated framework of depression pathology. The major nodes within the network framework of depression included hypothalamic-pituitary-adrenal (HPA) axis hyperactivity, inflammation, weakened monoaminergic systems, reduced neurogenesis/neuroplasticity, and poor microbiome diversity affecting the gut–brain axis. We detailed how each node has subsystems within them, including signaling pathways, specific target proteins, or transporters that interface with compounds in tea, mediating their antidepressant effects. A major pathway was found to be the ERK/CREB/BDNF signaling pathway, up-regulated by a number of compounds in tea including teasaponin, L-theanine, EGCG and combinations of tea catechins and their metabolites. Black tea theaflavins and EGCG are potent anti-inflammatory agents via down-regulation of NF-κB signaling. Multiple compounds in tea are effective modulators of dopaminergic activity and the gut–brain axis. Taken together, our findings show that constituents found in all major tea types, predominantly L-theanine, polyphenols and polyphenol metabolites, are capable of functioning through multiple pathways simultaneously to collectively reduce the risk of depression.

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Section: Mechanistic Considerationsmentioning

confidence: 99%

“…In the HIP, only DA levels significantly changed after theanine treatment. Despite the notable results, the authors were unable to identify the detailed signaling pathways responsible for the observed theanine-mediated improvements in monoamine neurotransmission [111].…”

Section: Mechanistic Considerationsmentioning

confidence: 99%

Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption

2019

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“…Studies have investigated the associations between L-theanine with dopamine and serotonin in rodents[51,59,60]. Yamada and colleagues have reported an increase of up to two-fold in dopamine levels induced by L-theanine perfusion in rat striatal brain[51].…”

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confidence: 99%

Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia

Sakamoto

Ribeiro

Bueno

et al. 2019

Pharmacological Research

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“…SPT was used to evaluate anhedonia-like behavior, which is a typical clinical manifestation of depressed patients. Locomotor activity in the OFT represents certain aspects of loss of interest, while the immobility time in FST and TST is taken as an index of behavioral despair in depression [17].…”

Section: Discussionmentioning

confidence: 99%

Gastrodiae Rhizoma Water Extract Ameliorates Hypothalamic–Pituitary–Adrenal Axis Hyperactivity and Inflammation Induced by Chronic Unpredictable Mild Stress in Rats

Wang

Dong

Wang

et al. 2020

BioMed Research International

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Gastrodiae Rhizoma is a highly valuable traditional herbal medicine commonly used to treat neurological disorders. The present study is designed to determine the antidepressant-like effect of the Gastrodiae Rhizoma water extract (GRWE) on a depression model and the potential mechanisms. The chronic unpredictable mild stress (CUMS) rat model was used to induce depression. The sucrose preference test, open field test, forced swimming test, and tail suspension test were performed to assess the depressive-like behaviors, respectively. Hypothalamic–pituitary–adrenal (HPA) function was measured via plasma corticosterone (CORT), adrenocorticotrophic hormone (ACTH), hypothalamic corticotropin-releasing factor (CRF), and glucocorticoid receptor (GR) concentrations. Plasma concentrations of proinflammatory cytokines including interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) were also evaluated. The results showed that GRWE significantly attenuates the behavioral abnormalities in CUMS rats, as shown by elevated sucrose consumption, raised locomotor activity, and reduced immobility duration. Moreover, GRWE treatment reduced CORT, ACTH, CRF, and GR levels and decreased the plasma IL-1β, IL-6, and TNF-α concentrations. These findings indicate that GRWE improves depressive behaviors in a chronic stress model of rats; its effect may be ascribed to the modulation of the HPA axis activity and inflammatory response.

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L‐theanine ameliorate depressive‐like behavior in a chronic unpredictable mild stress rat model via modulating the monoamine levels in limbic–cortical–striatal–pallidal–thalamic‐circuit related brain regions

Cited by 49 publications

References 63 publications

Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption

Mechanisms Underlying the Anti-Depressive Effects of Regular Tea Consumption

Psychotropic effects of L-theanine and its clinical properties: From the management of anxiety and stress to a potential use in schizophrenia

Gastrodiae Rhizoma Water Extract Ameliorates Hypothalamic–Pituitary–Adrenal Axis Hyperactivity and Inflammation Induced by Chronic Unpredictable Mild Stress in Rats

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