2023
DOI: 10.21203/rs.3.rs-3450804/v1
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L-Theanine inhibits cancer stem cell-mediated chemoresistance in lung cancer by regulating STAT3/NOTCH1-BMAL1 signaling

Wenjing Jin,
Ling Su,
Hong You
et al.

Abstract: Cancer stem cells play crucial roles in the development of cancer chemoresistance. L-Theanine, a nonproteinogenic amino acid derived from green tea, is gaining more and more attentions in reversing cancer drug resistance. However, its roles in development of lung cancer chemoresistance is still unknown. To investigate the effects of L-Theanine on chemoresistance and explore its underlying mechanism in lung cancer, we performed a panel of experiments in vitro combined with RNA-seq analysis and demonstrated L-Th… Show more

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