2021
DOI: 10.1016/j.intimp.2021.107476
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L-Threoascorbic acid treatment promotes S. aureus-infected primary human endothelial cells survival and function, as well as intracellular bacterial killing, and immunomodulates the release of IL-1β and soluble ICAM-1

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Cited by 4 publications
(4 citation statements)
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“…ECs, apart from their vascular function, are now considered as relevant immunoregulatory effectors in chronic inflammatory diseases (82,83). Following cellular damage, ECs release large amount of IL-1b and IL-6 and increase the expression of adhesion molecules, like E-selectin (CD62E) and ICAM-1 (CD54), that further contribute to the exacerbate inflammation and trained immunity (80), including in ATS. In the case of ATS, the persistent activation of the inflammatory state, due to trained immunity, has been hypothesized as a relevant mechanisms linking non-resolving inflammation in ATS (84)(85)(86).…”
Section: Nk Cells In Atherosclerosismentioning
confidence: 99%
See 1 more Smart Citation
“…ECs, apart from their vascular function, are now considered as relevant immunoregulatory effectors in chronic inflammatory diseases (82,83). Following cellular damage, ECs release large amount of IL-1b and IL-6 and increase the expression of adhesion molecules, like E-selectin (CD62E) and ICAM-1 (CD54), that further contribute to the exacerbate inflammation and trained immunity (80), including in ATS. In the case of ATS, the persistent activation of the inflammatory state, due to trained immunity, has been hypothesized as a relevant mechanisms linking non-resolving inflammation in ATS (84)(85)(86).…”
Section: Nk Cells In Atherosclerosismentioning
confidence: 99%
“…Upregulation of cell cholesterol is a relevant hallmark of the ATS plaque, exacerbating the pro-inflammatory state that impact on the plaque fate, by continuously damaging the ECs and SMCs, finally determining the plaque rupture. Of notice, upregulated cell cholesterol induce a signature of trained immunity ( 80 ). Trained immunity, a concept recently developed, refers to the ability of innate immunity to develop a specific memory as for adaptive immunity ( 17 ).…”
Section: Introductionmentioning
confidence: 99%
“…Many studies have confirmed that the endothelial cell immune response caused by bacteria is closely related to the inflammatory pathway proteins of HUVEC. 55 , 56 , 57 And bacterial adhesion to targets in endothelial cells may be a critical step in causing bacterial infection. It has been shown that Chlamydia Pneumoniae Cpn60 stimulates monocytes and induces metalloproteinase and pro-inflammatory cytokines synthesis.…”
Section: Discussionmentioning
confidence: 99%
“…Thus, vitamin C can be a safe and natural alternative to limit the growth of S. aureus when non-toxicity is required [5]. Moreover, in addition to its well-known immunomodulatory effects, it has recently been shown to possess immunomodulatory properties opposing interesting endothelial cell infection [6].…”
Section: Introductionmentioning
confidence: 99%