L-Tryptophan administered to chronic sleep-onset insomniacs: Late-appearing reduction of sleep latency

Spinweber, Cheryl L.

doi:10.1007/bf00181230

Cited by 27 publications

(11 citation statements)

References 26 publications

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“…In a dose-response study, Hartmann et al (1974) found that 1-15 g of L-Trp decreased sleep latency, but only doses above 5 g increased slow-wave sleep and decreased REM sleep. Other studies have failed to demonstrate modulations to sleep stages (Brown et al, 1979;Spinweber, 1986), which may, in part, be attributed to varying Trp doses. Spinweber (1986) found that 3 g L-Trp did not alter sleep stages or brain electrical activity during sleep in chronic sleep-onset insomniacs.…”

Section: Effect Of Tryptophan Loading On Sleep Parameters In Insomniacsmentioning

confidence: 91%

“…The bulk of evidence indicates that doses as low as 1 g L-Trp significantly reduce sleep latency and increase subjective ratings of sleepiness in subjects with insomnia (Brown et al, 1979;Hartmann et al, 1974;Hartman and Spinweber, 1979;Kö rner et al, 1986;Spinweber, 1986). Doses below 1 g have shown trends towards decreased sleep latency in mild insomniacs (Hartman and Spinweber, 1979).…”

Section: Effect Of Tryptophan Loading On Sleep Parameters In Insomniacsmentioning

confidence: 95%

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Effects of tryptophan loading on human cognition, mood, and sleep

Silber

Schmitt

2010

Neuroscience & Biobehavioral Reviews

217

161

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Section: Effect Of Tryptophan Loading On Sleep Parameters In Insomniacsmentioning

confidence: 91%

Section: Effect Of Tryptophan Loading On Sleep Parameters In Insomniacsmentioning

confidence: 95%

Effects of tryptophan loading on human cognition, mood, and sleep

Silber

Schmitt

2010

Neuroscience & Biobehavioral Reviews

217

161

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“…TRP decreases sleep latency in those with long sleep latencies [10][11][12]. However, TRP is able to give therapeutic improvement in chronic and severe in- Wong/Ong somniacs characterized by both sleep onset and sleep maintenance problems only after several days to weeks of therapy [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Acute Antidepressant-Like and Antianxiety-Like Effects of Tryptophan in Mice

Wong

Ong

2001

Pharmacology

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The antidepressant-like, antianxiety-like and sedative effects of tryptophan (TRP), in the absence and presence of p-chlorophenylalanine (p-CPA), and melatonin were studied in mice using the forced-swimming test, open-field test and activity cage, respectively. Single-dose TRP caused an antidepressant-like effect dose dependently up to 125 mg/kg. No significant effect was observed, however, when the TRP dose was increased to 250 mg/kg, i.e. a reversal of effect occurred at high dose. With p-CPA pretreatment, the effects observed at 125 and 250 mg/kg TRP were similar to those obtained at 50 and 125 mg/kg without p-CPA pretreatment, respectively. Melatonin also caused an antidepressant-like effect in a similar manner, but appeared to be less potent than TRP. These results strongly indicate that the antidepressant-like effect of TRP was due to its conversion to 5-hydroxytryptamine (5-HT). An antianxiety-like effect was observed for TRP only at 250 mg/kg dose together with p-CPA pretreatment, while no sedative effect was observed at all. In contrast, melatonin did not produce any antianxiety-like effect, but produced sedation at 200 mg/kg dose. It may be concluded that the antianxiety-like effect of TRP is unrelated to 5-HT and melatonin formation, but associated with TRP itself or, perhaps, with other anxiolytic metabolites.

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“…In a nighttime study, the sleep-promoting effects of 1-tryptophan 3 g were assessed in a group of chronic, sleep-onset insomniacs (Spinweber, 1986). In this study, 1-tryptophan reduced sleep latency significantly on the fourth through sixth nights of administration.…”

Section: L-tryptophan As a Sleeping Aidmentioning

confidence: 99%

Jet Lag In Military Operations: Field Trial Of L-Tryptophan In Reducing Sleep-Loss Effects

Spinweber¹,

Webb²,

Gillin³

1986

PsycEXTRA Dataset

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to the development of the protocol for this study.The conduct of militavy operations may involve rapid deployment across multiple time zones, altered work-rest schedules, and performance under conditions of sleep lose.We evaluated the sleep-promoting effects of the amino acid 1-tryptophan in the field in this study of the acute effects of rapid deployments on performance. Acute "jet-lag" effects were assessed by comparing data for B3. 01, and 02 at 0900, 1500, and 2100 LT by ANOVA for repeated measures. Post-hoe t-tests were used to identify sources of significant effects. For target shooting, factors were treatment group (placebo or 1-tryptophan) and day.Between-groups t-tests were used tt, compare total sleep for 1-tryptophan and placebo subjects.On the first night in Okinawa, total nighttime sleep time was significantly increased in the 1-tryptophan group (274.5 + 19.9 min versus 222.3 + 44.8, t-2,16, p<.0315, one-tailed).Our RT test, a very sensitive measure of fatigue, showed treatment differences with placebo subjects having significantly slower RT at 2100 on 01 (t-2.28, p<.0308, two-tailed). Mean sleep Ulme aboard the aircraft was 291 + 79 min for placebo subjects and 324 + 146 min for 1--tryptophan subjects. This 33-minute difference was not statistically significant. After arrival, evening performance showed the deleterious effects of "Jet lag". DSST and AT recovered by 02. STM showed a progressive deterioration from the time of arrival through the evening of 02. There was a consistent pattern in the various subjective measures of significantly poorer mood and increased sleepiness on 01 particularly in the evening.By L02, mood had recovered in the daytime but was still significantly worse at 2100 compared to 13. ILa 'Lraet shooting mean cnorep were Pigapifrantly lower oni 01 (29.2 + 10., vermin 21.n + 0-9 1-4.R7, "Jet lag" may be co;,sidered to be the result of multiple factors. Our interventions greatly reduced the impacL of sleep-loss effects associated with this deployment. The Inflight environmental controls increased sleep during transit; data collected earlier in a pilot study showed mean sleep time en route to be only 2 + 1.2 h, when environmental controls were not employed and no pills were given.L-tryptophan administration increased total sleep time on the first night after arrival, and this increase in sleep wan associated with faster reaction time in the evening the following day. In addition, 1-tryptophan use appeared to spare short-term memory from ,Jet-lag effects and hastened the recovery of reaction-time performance.Au far as we are aware, this study is the first demonstration that improving sleep by psychopharmacological means is associated rith enhanced performance the next day. Previous research on westward flight has indicated that readjustment occurs relatively quickly, particularly in young, military subjects. Our data show "Jet-lag" effects on mood and performance on the first day after arrival with most dramatic decrements in tho evening test battery. Many measuresshow changes wh...

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L-Tryptophan administered to chronic sleep-onset insomniacs: Late-appearing reduction of sleep latency

Cited by 27 publications

References 26 publications

Effects of tryptophan loading on human cognition, mood, and sleep

Effects of tryptophan loading on human cognition, mood, and sleep

Acute Antidepressant-Like and Antianxiety-Like Effects of Tryptophan in Mice

Jet Lag In Military Operations: Field Trial Of L-Tryptophan In Reducing Sleep-Loss Effects

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