L'ulcère de Marjolin, destinée d'une cicatrice instable. À propos de 54 cas de séquelles de brûlure

Chlihi, A; Bouchta, A; Benbrahim, A.; Bahechar, N.; Boukind, E.H.

doi:10.1016/s0294-1260(02)00120-6

Cited by 11 publications

(5 citation statements)

References 28 publications

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“…Similar to the initial demonstrations of some authors, [13,16,17], all burnings before cancer were serious burnings, of 2nd deep degree or 3rd degree. None of Marjolin's Ulcer case on burning of 1st degree was not reported in our series and those of some authors [13].…”

Section: Clinical Aspectssupporting

confidence: 82%

“…The death-rate of 71.41% presented in this working is assimilating of the 75% told by Nsondé-Malanda [12]. Lower death-rates were examined by Kassé [13] and Chlihi [17], respectively of 9.2% and 11%. The inappropriate care of the initial lesion, the diagnosis delay and the advanced stage of the disease at the point of diagnosis contributed to the high mortality of our series cases.…”

Section: Evolutionary Aspectmentioning

confidence: 91%

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Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville

Malanda¹,

Kombo²,

Maye³

et al. 2019

IJCOCR

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Introduction Marjolin's Ulcer (MU) means all cutaneous malignancies developed on old unsteady scars. The general objective of this study was to report the MU cases in Congo with a literature review. It was a retrospective study conducted at University Teaching Hospital in Brazzaville from January 1998 to December 2017 (a 20-year period). The in-patients for cutaneous cancer histologically confirmed, arose on scarring skin lesions progressive were included. The epidemiological, clinical, histopathological and therapeutical variables were collected. Seven patients were identified. They represented 1.9% of skin cancers. The middle age was 44.4 years. The female predomination was noted with a sex ratio of 2.5. The burn scars was the etiological factor found to all our patients (100%). None of patients had an appropriate care of initial wound. The average time limit of the onset of MU was 34 years. The anatomopathologic examination revealed a squamous cell carcinoma to all our patients (100%). Carcinologic exeresis carried out to one (01) patient (14.28%). The amputation: three (03) patients (42.85%) and the disarticulation: two (02) patients (28.57%). The chemotherapy six (06) patients (85.71%). The decease arose five (05) patients (71.42%) and the entire remission reached to a woman patient (14.28%). This study confirmed the rareness and the severity MU; it also reveals the diagnosis lateness of a great death-rate. The care of quality of burns and chronic injuries, the awareness of patients together with the care givers training could help to improve the prognosis of this affection.

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Section: Clinical Aspectssupporting

confidence: 82%

Section: Evolutionary Aspectmentioning

confidence: 91%

Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville

Malanda¹,

Kombo²,

Maye³

et al. 2019

IJCOCR

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Section: Discussionmentioning

confidence: 99%

“…Current studies in Africa have reported that the mean age of patients with Marjolin's ulcers is lowering and appears to be affecting younger patients over the years [12,20]. It also appears that the transition time is getting shorter [20]. Marjolin's ulcers in general, develop in younger patients amongst sub-Saharan patients than those reported from other regions [12]; therefore, patients presenting with chronic ulcers should be investigated during the initial evaluation for this possibility.…”

Section: Discussionmentioning

confidence: 99%

Marjolin's ulcers at a university teaching hospital in Northwestern Tanzania: a retrospective review of 56 cases

et al. 2012

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BackgroundMarjolin's ulcer is a rare but highly aggressive squamous cell cancer that is most often associated with chronic burn wounds. Although many individual case reports exist, no comprehensive evaluation of Marjolin's ulcer patients has been conducted in our setting. This study was conducted to describe the clinicopathological presentation and treatment outcome of this condition in our local setting and to identify predictors of outcome.MethodsThis was a retrospective study of histologically confirmed cases of Marjolin's ulcer seen at Bugando Medical Centre over a period of 10-years between January 2001 and December 2010. Data were retrieved from patients' files and analyzed using SPSS computer software version 15.0ResultsA total of 56 patients were studied. Male to female ratio was 2.1:1. Burn scars (89.3%) were the most common causative lesions of Marjolin's ulcer. The mean latent period between original injury and diagnosis of Marjolin's ulcer was 11.34 ± 6.14 years. Only 12.0% of the reported cases were grafted at the time of injury (P < 0.00). Most patients (48.2%) presented between one and five years of onset of illness. The lower limb (42.9%) was the most frequent site for Marjolin's ulcers. The median tumor size at presentation was 8 cm and the vast majority of patients (85.7%) presented with large tumors of ≥ 5 cm in diameter. Lymph node metastasis at the time of diagnosis was recorded in 32.1% of cases and distant metastasis accounted for 26.9% of cases. Squamous cell carcinoma (91.1%) was the most common histopathological type. Wide local excision was the most common surgical procedure performed in 80.8% of cases. Post-operative complication rate was 32.1% of which surgical site infection was the most common complication in 38.9% of patients. Local recurrence was noted in 33.3% of cases who were treated surgically. The mean length of hospital stay for in-patients was 7.9 ± 2.3 days. Mortality rate was 7.1%. According to multivariate logistic regression analysis, stage and grade of the tumor and presence of local recurrence were the main predictors of death (P < 0.001).ConclusionMarjolin's ulcers are not rare in our environment and commonly occur in burn scars that were not skin grafted and were left to heal secondarily. A high index of suspicion is required in the management of chronic non-healing ulcers and all suspected lesions should be biopsed. Early recognition and aggressive treatment of Marjolin's ulcers and close follow-up are urgently needed to improve outcomes in our environment.

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“…Extremity is probably the location of the most aggressive form of MU [2][3][4][5][6]. Surgical removal early in the course of the tumor is the mainstay of management, though newer modalities such as cryosurgery, intralesional interferons, 5-fluorouracil or methotrexate, and photodynamic therapy are described without much established definitive role [12]. The outcome of the metastatic disease is very poor, and surgical management and/or chemoradiotherapy have limited benefits other than palliation.…”

Section: Discussionmentioning

confidence: 99%

Lower Extremity Marjolin’s Ulcer Reconstruction With Free Anterolateral Thigh Flap: A Case Series of 11 Patients

Sharma

Das

Gupta

et al. 2020

Cureus

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Background Marjolin’s ulcer (MU) of lower extremities usually presents with scar contracture and functional disability. They often follow an aggressive course and poor outcome, and require early radical removal. Split-thickness skin grafts, local flaps, or amputation are commonly practiced surgical options for MU. Though free flaps are gaining popularity for various oncoplastic reconstruction, they are not frequently used for MU. A free anterolateral thigh (ALT) flap may have a beneficial role as it provides simultaneous coverage for a large defect after radical tumor and scar excision. Methods Between January 2015 and December 2018, 11 patients with lower limb MU reconstructed with free ALT flap were reviewed retrospectively for the surgical procedure, recurrences, and functional outcomes. Results Mean dimensions of the defect and flaps were 8 cm × 6 cm and 18.91 cm × 11 cm, respectively, and total flap coverage was obtained in nine cases. Marginal flap loss was noted in one and residual contracture in two cases. Functional improvement of the limb was achieved in all cases. Recurrence or disease-related mortality was not seen in any patient after a mean follow-up of 35.82 months. Conclusions Free ALT flap reconstruction of MU of extremity facilitates most radical tumor and scar-contracture removal and thus reduces the chances of re-ulceration. It facilitates local radiotherapy protocol with the provision of immediate durable coverage. Thus, it has a beneficial role other than a secondary reconstructive procedure. Moreover, an added benefit may be obtained with a “flow-through’ flap” to avoid amputation and improve functional outcomes.

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L'ulcère de Marjolin, destinée d'une cicatrice instable. À propos de 54 cas de séquelles de brûlure

Cited by 11 publications

References 28 publications

Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville

Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville

Marjolin's ulcers at a university teaching hospital in Northwestern Tanzania: a retrospective review of 56 cases

Lower Extremity Marjolin’s Ulcer Reconstruction With Free Anterolateral Thigh Flap: A Case Series of 11 Patients

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L'ulcère de Marjolin, destinée d'une cicatrice instable. À propos de 54 cas de séquelles de brûlure

Cited by 11 publications

References 28 publications

Marjolin&apos;s Ulcer: Seven (07) Cases Studied in Brazzaville

Marjolin&apos;s Ulcer: Seven (07) Cases Studied in Brazzaville

Marjolin's ulcers at a university teaching hospital in Northwestern Tanzania: a retrospective review of 56 cases

Lower Extremity Marjolin’s Ulcer Reconstruction With Free Anterolateral Thigh Flap: A Case Series of 11 Patients

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Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville

Marjolin's Ulcer: Seven (07) Cases Studied in Brazzaville