L-α-Phosphatidylcholine attenuates mercury-induced hepato-renal damage through suppressing oxidative stress and inflammation

Elblehi, Samar S.; Hafez, Mona H.; El‐Sayed, Yasser S.

doi:10.1007/s11356-019-04395-9

Cited by 39 publications

(16 citation statements)

References 51 publications

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“…In the present study, liver and renal functions were detrimentally altered after HgCl 2 administration causing hepatorenal dysfunction evidenced by a significant elevation in AST, ALT, and ALP enzyme activities and urea, uric acid, and creatinine levels. Similar results were reported by [22,23]. Treatment with DPPD showed a marked improvement that was clear in the previously listed parameters, and these findings agreed with those of Kawai et al [13] who reported that DPPD may possess an antioxidative behavior.…”

Section: Discussionsupporting

confidence: 91%

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Nabil

Elshemy

Asem

et al. 2020

Journal of Toxicology

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Mercury is a global environmental pollutant, accumulating mainly in the kidney and liver inducing hepatorenal toxicity, oxidative stress, and tissue damage. Oxidative stress is caused by an imbalance between free radicals’ production and cellular antioxidant defense systems. In the present study, we investigated the effect of N N′-diphenyl-1, 4-phenylenediamine (DPPD) antioxidant activity against mercury chloride- (HgCl2-) induced renal and hepatic toxicity. Thirty adult female Sprague Dawley rats were divided into three equal groups: the first group was injected with saline only and served as a control, the second group was injected with HgCl2, and the third group received DPPD + HgCl2 rats injected with HgCl2 without treatment showing a significant increase in alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, and uric acids compared to control. Moreover, the second group showed a significant reduction in the activity of the antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH)) in addition to a marked increase in the malondialdehyde (MDA) content, histopathological alterations, collagen deposition, CD8%, CD4%, and TGF-β% in kidney and liver tissues compared with the control group. Treatment with DPPD showed significant recovery (p≤0.001) in all previous parameters and histopathological examination. In conclusion, we suggested that DPPD may have a promising antioxidant capacity, gives it the applicability to be used as a prophylactic agent against mercury-induced hepatorenal cytotoxicity in the future.

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Section: Discussionsupporting

confidence: 91%

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Nabil

Elshemy

Asem

et al. 2020

Journal of Toxicology

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“…Proteinuria is a likely predictive risk factor for chronic renal damage as earlier described (Skowron et al., 2019). Other findings have reported the enhancement of proinflammatory cytokines in glomerulonephritis and glomerulonephropathy (Elblehi et al., 2019; Xu et al., 2019). Hence, the presence of leukocytes and neutrophils observed in the urine samples of UNX hypertensive rats was an indication of an on‐going inflammatory reaction that might be associated with or precipitated by uninephrectomy.…”

Section: Discussionmentioning

confidence: 81%

“…Proteinuria is a likely predictive risk factor for chronic renal damage as earlier described (Skowron et al, 2019). Other findings have reported the enhancement of proinflammatory cytokines in glomerulonephritis and glomerulonephropathy (Elblehi et al, 2019;Xu et al, 2019). , 2012).…”

Section: Discussionmentioning

confidence: 87%

Novel antihypertensive action of rutin is mediated via inhibition of angiotensin converting enzyme/mineralocorticoid receptor/angiotensin 2 type 1 receptor (ATR1) signaling pathways in uninephrectomized hypertensive rats

et al. 2020

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Hypertension is the most common cardiovascular disease that affects approximately 26% of adult population, worldwide. Rutin is one of the important flavonoids that is consumed in the daily diet, and found in many food items, vegetables, and beverages. Uninephrectomy (UNX) of the left kidney was performed, followed by induction of hypertension. The rats were randomly divided into four groups of 10 rats: group 1-Sham-operated rats; group 2-UNX rats, group 3-UNX-L-NAME (40 mg/ kg) plus rutin (100 mg/kg bwt), and groups 4-UNX-L-NAME plus lisinopril (10 mg/kg bwt), orally for 3 weeks. Results revealed significant heightening of arterial pressure and oxidative stress indices, while hypertensive rats treated with rutin had lower expressions of angiotensin converting enzyme (ACE) and mineralocorticoid receptor in uninephrectomized rats. Together, rutin as a novel antihypertensive flavonoid could provide an unimaginable benefits for the management of hypertension through inhibition of angiotensin converting enzyme and mineralocorticoid receptor. Practical applications Hypertension has been reported to be the most common cardiovascular disease, affecting approximately 26% of the adult population worldwide with predicted prevalence to increase by 60% by 2025. Recent advances in phytomedicine have shown flavonoids to be very helpful in the treatment of many diseases. Flavonoids have been used in the treatment and management of cardiovascular diseases, obesity and hypertension. The study revealed that rutin, a known flavonoid inhibited angiotensin converting enzyme (ACE), angiotensin 2 type 1 receptor (ATR1), and mineralocorticoid

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“…In addition, PC is an important component of synovial fluid and cartilage and can inhibit cartilage hydration, scavenge oxygen free radicals and resist adhesion [30]. Several clinical studies and experiments have demonstrated that PC can alleviate the consequences of inflammation in different organs [31][32][33]. In general, PC can (1) reduce the interfacial tension and friction coefficient of articular cartilage, improve the physiological function of slide fluid, improve lubrication, and reduce cartilage wear; (2) reduce synovitis by controlling the synthesis and release of inflammatory mediators, such as IL-1β and TNF-α; and (3) inhibit the destruction of cartilage by inflammatory mediators in inflammatory joints, stimulate the synthesis of proteoglycan (PG), control the release of chondroitin-degrading enzymes, and accelerate the synthesis and metabolism of cartilage to stabilize and repair articular cartilage ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

Interventional effects of the direct application of “Sanse powder” on knee osteoarthritis in rats as determined from lipidomics via UPLC-Q-Exactive Orbitrap MS

Huang

Shan

et al. 2020

Chin Med

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Background: Our previous clinical evidence suggested that the direct application of "Sanse powder" the main ingredient of "Yiceng" might represent an alternative treatment for knee osteoarthritis. However, the mechanism underlying its effect is poorly understood. In this study, we investigated the mechanism of the effect of direct "Sanse powder" application for the treatment of knee osteoarthritis (KOA) in rats by using lipidomics. Methods: KOA rats were established by cutting the anterior cruciate ligament, and the cold pain threshold and mechanical withdrawal threshold (MWT) of seven rats from each group were measured before modelling (0 days) and at 7, 14, 21 and 28 days after modelling. Histopathological evaluation of the synovial tissue was performed by haematoxylin and eosin (H&E) staining after modelling for 28 days. Interleukin-1β (IL-1β), pro-interleukin-1β (pro-IL-1β) and tumor necrosis factor-α (TNF-α) proteins in synovial tissue were measured by western blot, and the mRNA expression levels of IL-1β and TNF-α in synovial tissue were measured using Real-time reverse transcription polymerase chain reaction (qRT-PCR), the levels of IL-1β and TNF-α in rat serum were measured by enzyme-linked immunosorbent assay (ELISA), Serum lipid profiles were obtained by using ultra-performance liquid chromatography combined with quadrupole-Exactive Orbitrap mass spectrometry (UPLC-Q-Exactive Orbitrap MS). Results: The results confirmed that the direct application of "Sanse powder" had a significant protective effect against KOA in rats. Treatment with "Sanse powder" not only attenuated synovial tissue inflammation but also increased the levels of the cold pain threshold and MWT. In addition, the lipidomics results showed that the levels of diacylglycerol (DAG), triacylglycerols (TAGs), lysophosphatidylcholine (LPC), phosphatidylcholine (PC), fatty acid esters of hydroxy fatty acids (FAHFAs), and phosphatidylethanolamine (PE) were restored almost to control levels following treatment. Conclusions: Lipidomics provides a better understanding of the actions of direct application "Sanse powder" therapy for KOA.

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L-α-Phosphatidylcholine attenuates mercury-induced hepato-renal damage through suppressing oxidative stress and inflammation

Cited by 39 publications

References 51 publications

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Protective Effect of DPPD on Mercury Chloride-Induced Hepatorenal Toxicity in Rats

Novel antihypertensive action of rutin is mediated via inhibition of angiotensin converting enzyme/mineralocorticoid receptor/angiotensin 2 type 1 receptor (ATR1) signaling pathways in uninephrectomized hypertensive rats

Interventional effects of the direct application of “Sanse powder” on knee osteoarthritis in rats as determined from lipidomics via UPLC-Q-Exactive Orbitrap MS

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