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Stjernholm-Vladic, Ylva; Stygar, Denis; Månsson, Christopher; Masironi, Britt; Åkerberg, Sonja; Wang, Hong; Ekman-Ordeberg, Gunvor; Sahlin, Lena

doi:10.1186/1477-7827-2-74

Cited by 71 publications

(19 citation statements)

References 58 publications

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“…Our results showed no significant difference in levels of PR expression between the groups, GR and NC. This may be due to the fact that increases in PR are principally associated with the onset of labor and may thus explain the lack of difference in levels in both patient groups [12,31]. Interestingly, placental PR mRNA expression levels were significantly correlated to IGF-I mRNA expression, gestational age, and to infant birth height and weight, in the GR group, suggesting that this nuclear receptor may indeed play a role in placental IGF-I regulation and fetoplacental growth.…”

Section: Discussionmentioning

confidence: 99%

Placental IGF-I, Estrogen Receptor, and Progesterone Receptor Expression, and Maternal Anthropometry in Growth-Restricted Pregnancies in the Swedish Population

Akram¹,

Sahlin²,

Östlund

et al. 2010

Horm Res Paediatr

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Background/Aims: Fetal growth restriction is a complex problem of pregnancy arising from multiple etiologies. Key regulatory elements of growth are the insulin-like growth factor (IGF) axis, and estrogen and progesterone receptors. The aims were to determine the relations of expression of IGF-I, estrogen receptors α and β (ERα and ERβ, respectively), and progesterone receptor (PR), with maternal anthropometry, focusing on birth weight outcomes. Methods: Placental samples were obtained from 33 patients following delivery. mRNA expression was determined by a solution hybridization technique. Samples were divided into normal control (NC) and growth-restricted (GR) groups. Results: IGF-I expression was lower in the GR as compared to the NC group. PR levels correlated positively with IGF-I expression, infant anthropometry, and gestational age (GR). ERα correlated positively with PR expression (NC), and maternal BMI at delivery (GR). ERβ correlated positively with maternal delivery weight and gestational age (NC). Conclusion: The differences in placental expression of IGF-I emphasize its key role in birth weight outcomes. We further suggest the importance of PR expression in the pathogenesis of intrauterine growth restriction, as there were direct correlations of PR expression with both IGF-I expression and infant anthropometric parameters, as well as gestational age.

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Section: Discussionmentioning

confidence: 99%

Placental IGF-I, Estrogen Receptor, and Progesterone Receptor Expression, and Maternal Anthropometry in Growth-Restricted Pregnancies in the Swedish Population

Akram¹,

Sahlin²,

Östlund

et al. 2010

Horm Res Paediatr

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“…Human parturition is characterized by an inflammatory response that has been demonstrated in the cervix, 1–11 myometrium, 9,10,12–14 and choriodecidua. 9,10,12,15–22 Indeed, leukocyte infiltration has been demonstrated in all these tissues in humans.…”

Section: Introductionmentioning

confidence: 99%

Evidence for a Role for the Adaptive Immune Response in Human Term Parturition

Gomez‐Lopez¹,

Vega-Sánchez

Castillo-Castrejón

et al. 2013

American J Rep Immunol

132

139

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PROBLEM Spontaneous labor at term involves leukocyte recruitment and infiltration into the choriodecidua; yet, characterization of these leukocytes and their immunological mediators is incomplete. The purpose of this study was to characterize the immunophenotype of choriodecidual leukocytes as well as the expression of inflammatory mediators in human spontaneous parturition at term. METHOD OF STUDY Choriodecidual leukocytes were analyzed by FACS, immunohistochemistry, and RT-PCR in three different groups: (i) preterm gestation delivered for medical indications without labor; (ii) term pregnancy without labor; and (iii) term pregnancy after spontaneous labor. RESULTS Two T-cell subsets of memory-like T cells (CD3+CD4+CD45RO+ and CD3+CD4−CD8−CD45RO+ cells) were identified in the choriodecidua of women who had spontaneous labor. Evidence for an extensive immune signaling network composed of chemokines (CXCL8 and CXCL10), chemokine receptors (CXCR1-3), cytokines (IL-1β and TNF-α), cell adhesion molecules, and MMP-9 was identified in these cells during spontaneous labor at term. CONCLUSIONS The influx of memory-like T cells in the choriodecidua and the evidence that they are active by producing chemokines and cytokines, and expressing chemokine receptors, cell adhesion molecules, and a matrix-degrading enzyme provides support for the participation of the adaptive immune system in the mechanisms of spontaneous parturition at term.

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“…Ripening or softening of the uterine cervical tissue is a process involving various inflammatory reactions,1,2 although the mechanisms are poorly understood. Ripening of the cervix in early pregnancy is recommended before surgical abortion to facilitate cervical dilatation,3 later in pregnancy to induce labour,4 and in non-pregnant women if intrauterine surgery is indicated 5,6.…”

Section: Introductionmentioning

confidence: 99%

A combination of misoprostol and estradiol for preoperative cervical ripening in postmenopausal women: a randomised controlled trial

Oppegaard

Lieng

Berg

et al. 2009

BJOG

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ObjectiveTo compare the impact of 1000 μg of self-administered vaginal misoprostol versus self-administered vaginal placebo on preoperative cervical ripening after 2 weeks of pretreatment with estradiol vaginal tablets in postmenopausal women prior to day-care operative hysteroscopy.DesignRandomised, double-blind, placebo-controlled sequential trial.SettingNorwegian university teaching hospital.PopulationSixty-seven postmenopausal women referred for day-care operative hysteroscopy.MethodsThe women were randomised to receive either 1000 μg of self-administered vaginal misoprostol or self-administered vaginal placebo on the evening before day-care operative hysteroscopy. All women had administered a 25-μg vaginal estradiol tablet daily for 14 days prior to the operation.Main outcome measuresPrimary outcome: preoperative cervical dilatation at hysteroscopy. Secondary outcomes: difference in dilatation at recruitment and before hysteroscopy, number of women who achieved a preoperative cervical dilatation of 5 mm or more, acceptability, complications and adverse effects.ResultsThe mean cervical dilatation was 5.7 mm (SD, 1.6 mm) in the misoprostol group and 4.7 mm (SD, 1.5 mm) in the placebo group, the mean difference in cervical dilatation being 1.0 mm (95% CI, 0.2–1.7 mm). Self-administered vaginal misoprostol of 1000 μg at home on the evening before day-care hysteroscopy is safe and highly acceptable, although a small proportion of women experienced lower abdominal pain.ConclusionsOne thousand micrograms of self-administered vaginal misoprostol, 12 hours prior to day-care hysteroscopy, after 14 days of pretreatment with vaginal estradiol, has a significant cervical ripening effect compared with placebo in postmenopausal women.

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Cited by 71 publications

References 58 publications

Placental IGF-I, Estrogen Receptor, and Progesterone Receptor Expression, and Maternal Anthropometry in Growth-Restricted Pregnancies in the Swedish Population

Placental IGF-I, Estrogen Receptor, and Progesterone Receptor Expression, and Maternal Anthropometry in Growth-Restricted Pregnancies in the Swedish Population

Evidence for a Role for the Adaptive Immune Response in Human Term Parturition

A combination of misoprostol and estradiol for preoperative cervical ripening in postmenopausal women: a randomised controlled trial

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